Gestational Hypothyroidism Improves the Ability of the Female Offspring to Clear Streptococcus pneumoniae Infection and to Recover From Pneumococcal Pneumonia

Maternal thyroid hormones are essential for proper fetal development. A deficit of these hormones during gestation has enduring consequences in the central nervous system of the offspring, including detrimental learning and impaired memory. Few studies have shown that thyroid hormone deficiency has...

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Veröffentlicht in:Endocrinology (Philadelphia) 2016-06, Vol.157 (6), p.2217-2228
Hauptverfasser: Nieto, Pamela A, Peñaloza, Hernán F, Salazar-Echegarai, Francisco J, Castellanos, Raquel M, Opazo, Maria Cecilia, Venegas, Luis, Padilla, Oslando, Kalergis, Alexis M, Riedel, Claudia A, Bueno, Susan M
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container_issue 6
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container_title Endocrinology (Philadelphia)
container_volume 157
creator Nieto, Pamela A
Peñaloza, Hernán F
Salazar-Echegarai, Francisco J
Castellanos, Raquel M
Opazo, Maria Cecilia
Venegas, Luis
Padilla, Oslando
Kalergis, Alexis M
Riedel, Claudia A
Bueno, Susan M
description Maternal thyroid hormones are essential for proper fetal development. A deficit of these hormones during gestation has enduring consequences in the central nervous system of the offspring, including detrimental learning and impaired memory. Few studies have shown that thyroid hormone deficiency has a transient effect in the number of T and B cells in the offspring gestated under hypothyroidism; however, there are no studies showing whether maternal hypothyroidism during gestation impacts the response of the offspring to infections. In this study, we have evaluated whether adult mice gestated in hypothyroid mothers have an altered response to pneumococcal pneumonia. We observed that female mice gestated in hypothyroidism have increased survival rate and less bacterial dissemination to blood and brain after an intranasal challenge with Streptococcus pneumoniae. Further, these mice had higher amounts of inflammatory cells in the lungs and reduced production of cytokines characteristic of sepsis in spleen, blood, and brain at 48 hours after infection. Interestingly, mice gestated in hypothyroid mothers had basally increased vascular permeability in the lungs. These observations suggest that gestational hypothyroidism alters the immune response and the physiology of lungs in the offspring, increasing the resistance to respiratory bacterial infections.
doi_str_mv 10.1210/en.2015-1957
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
subjects Animals
Bacteria
Bacterial diseases
Bacterial infections
Blood
Brain
Brain - immunology
Brain - microbiology
Cell survival
Central nervous system
Disease Models, Animal
Disease Resistance - immunology
Female
Females
Fetuses
Gestation
Hormones
Human health and pathology
Hypothyroidism
Hypothyroidism - immunology
Immune response
Immunological memory
Life Sciences
Lung - immunology
Lung - microbiology
Lungs
Lymphocytes B
Memory cells
Mice
Mice, Inbred C57BL
Neutrophils - physiology
Offspring
Pneumococcal Infections - immunology
Pneumonia
Pneumonia, Pneumococcal - immunology
Pregnancy
Prenatal Exposure Delayed Effects - immunology
Prenatal Exposure Delayed Effects - microbiology
Sepsis
Sepsis - immunology
Sepsis - microbiology
Streptococcus infections
Streptococcus pneumoniae
Thyroid
Thyroid gland
Thyroid hormones
title Gestational Hypothyroidism Improves the Ability of the Female Offspring to Clear Streptococcus pneumoniae Infection and to Recover From Pneumococcal Pneumonia
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