Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Variants of the CFH gene, encoding complement factor H (CFH), show strong association with age-related macular degeneration (AMD), a major cause of blindness. Here, we used murine models of AMD to examine the contribution of CFH to disease etiology. Cfh deletion protected the mice from the pathogeni...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2017-02, Vol.46 (2), p.261-272
Hauptverfasser:	Calippe, Bertrand, Augustin, Sebastien, Beguier, Fanny, Charles-Messance, Hugo, Poupel, Lucie, Conart, Jean-Baptiste, Hu, Shulong J., Lavalette, Sophie, Fauvet, Alexandre, Rayes, Julie, Levy, Olivier, Raoul, William, Fitting, Catherine, Denèfle, Thomas, Pickering, Matthew C., Harris, Claire, Jorieux, Sylvie, Sullivan, Patrick M., Sahel, José-Alain, Karoyan, Philippe, Sapieha, Przemyslaw, Guillonneau, Xavier, Gautier, Emmanuel L., Sennlaub, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Bone marrow CD47 Antigen CD47 Antigen - immunology Cellular Biology Complement Factor H Complement Factor H - genetics Complement Factor H - immunology Disease Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Human health and pathology Immunohistochemistry Immunology Inflammation Inflammation - genetics Inflammation - immunology Life Sciences Macular Degeneration Macular Degeneration - genetics Macular Degeneration - immunology Mice Mice, Knockout Pathogenesis Peritonitis Peritonitis - genetics Peritonitis - immunology Photoreceptors Polymorphism, Single Nucleotide Sensory Organs Statistical analysis Variance analysis
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