Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers

Abstract Developing protocols aimed at inhibiting effector T cells would be key for the treatment of T cell-dependent autoimmune diseases including type 1 autoimmune diabetes (T1D) and multiple sclerosis (MS). While heme oxygenase-1 (HO-1) inducers are clinically approved drugs for non-immune-relate...

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Veröffentlicht in:	Journal of autoimmunity 2017-07, Vol.81, p.44-55
Hauptverfasser:	Simon, Thomas, Pogu, Julien, Rémy, Séverine, Brau, Frédéric, Pogu, Sylvie, Maquigneau, Maud, Fonteneau, Jean-François, Poirier, Nicolas, Vanhove, Bernard, Blancho, Gilles, Piaggio, Eliane, Anegon, Ignacio, Blancou, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigens - immunology Auto-immune encephalomyelitis Autoantigens - immunology Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmune Diseases - pathology Autoimmunity Cancer CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cytokines - metabolism Delayed type hypersensitivity Diabetes Gene Expression Regulation Heme oxygenase-1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Humans Hypersensitivity, Delayed - genetics Hypersensitivity, Delayed - immunology Hypersensitivity, Delayed - metabolism Immunization Life Sciences Mice Mice, Transgenic Migration Monocyte-derived dendritic cells Myelin-Oligodendrocyte Glycoprotein - immunology Papio anubis T-Cell Antigen Receptor Specificity - immunology T-lymphocyte T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tolerance
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