Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: A joint experimental and computational highlight based on 7-O-galloylsilybin

[Display omitted] •Interaction of semi-synthetically prepared flavonolignan (7-O-galloylsilybin) with DNA is described.•We present evidence about interactions of flavonolignans with transition metals and DNA-damage.•Antioxidant and prooxidant effects of flavonolignans are investigated and discussed...

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Veröffentlicht in:	Chemico-biological interactions 2013-10, Vol.205 (3), p.173-180
Hauptverfasser:	Vacek, Jan, Zatloukalová, Martina, Desmier, Thomas, Nezhodová, Veronika, Hrbáč, Jan, Kubala, Martin, Křen, Vladimír, Ulrichová, Jitka, Trouillas, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Antioxidants Antioxidants - chemistry Antioxidants - metabolism Antioxidants - pharmacology Biphenyl Compounds Biphenyl Compounds - metabolism Copper Copper - metabolism DNA Damage Electrochemical Techniques Flavonolignans Life Sciences Luminescent Measurements Molecular Dynamics Simulation Nucleic acids Pharmaceutical sciences Picrates Picrates - metabolism Prooxidant effects Silymarin Silymarin - analogs & derivatives Silymarin - chemistry Silymarin - metabolism Silymarin - pharmacology Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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