Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration
Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here,...
Gespeichert in:
| Veröffentlicht in: | Stem cells (Dayton, Ohio) Ohio), 2013-02, Vol.31 (2), p.384-396 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 396 |
|---|---|
| container_issue | 2 |
| container_start_page | 384 |
| container_title | Stem cells (Dayton, Ohio) |
| container_volume | 31 |
| creator | Saclier, Marielle Yacoub‐Youssef, Houda Mackey, Abigail L. Arnold, Ludovic Ardjoune, Hamida Magnan, Mélanie Sailhan, Frédéric Chelly, Jamel Pavlath, Grace K. Mounier, Rémi Kjaer, Michael Chazaud, Bénédicte |
| description | Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here, we explored both in vitro and in vivo, in human, the interactions of differentially activated MPs with myogenic precursor cells (MPCs) during adult myogenesis and skeletal muscle regeneration. We showed in vitro that through the differential secretion of cytokines and growth factors, proinflammatory MPs inhibited MPC fusion while anti‐inflammatory MPs strongly promoted MPC differentiation by increasing their commitment into differentiated myocytes and the formation of mature myotubes. Furthermore, the in vivo time course of expression of myogenic and MP markers was studied in regenerating human healthy muscle after damage. We observed that regenerating areas containing proliferating MPCs were preferentially associated with MPs expressing proinflammatory markers. In the same muscle, regenerating areas containing differentiating myogenin‐positive MPCs were preferentially coupled to MPs harboring anti‐inflammatory markers. These data demonstrate for the first time in human that MPs sequentially orchestrate adult myogenesis during regeneration of damaged skeletal muscle. These results support the emerging concept that inflammation, through MP activation, controls stem cell fate and coordinates tissue repair. STEM CELLS2013;31:384–396 |
| doi_str_mv | 10.1002/stem.1288 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_inserm_00787108v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1287885652</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5648-c91553cf424c7c0ec8842378b0cb7531fb43b8e5166ea87ae15e5265c0366a9b3</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhi0EakvbAy-ALHEBibR2YjuT42rbski7akXL2XLcya6Lkyx20mrfHoctPSAhTh5pvvnkf4aQd5ydccby8zhge8ZzgFfkiEtRZaLi8DrVTKlMsqo6JG9jfGCMCwlwQA7zgqtKcXlEni5c02DAbnDG-x2d2cE9mgHv6crY0G83Zo2RXge7wTiE1KCrXb_Gzll6E9COIfaBztF7ejU1L8bgujVdjK3p6O0P9DgYT1djtB7pN0yDmCSu707Im8b4iKfP7zH5fnV5N19ky-svX-ezZWalEpDZiktZ2EbkwpaWoQUQeVFCzWxdyoI3tShqQMmVQgOlQS5R5kpaVihlqro4Jp_33o3xehtca8JO98bpxWypXRcxtJqxEkrO4JEn_OMe34b-55gi69ZFm-KZDvsxai4KwdKiBfwfzaEEkErmCf3wF_rQj6FLuSdKSVkKPgk_7am09xgDNi__5UxPd9bTnaeJiX3_bBzrFu9fyD-HTcD5HnhyHnf_Nunbu8vVb-Uv_qmx1w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1286557418</pqid></control><display><type>article</type><title>Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Saclier, Marielle ; Yacoub‐Youssef, Houda ; Mackey, Abigail L. ; Arnold, Ludovic ; Ardjoune, Hamida ; Magnan, Mélanie ; Sailhan, Frédéric ; Chelly, Jamel ; Pavlath, Grace K. ; Mounier, Rémi ; Kjaer, Michael ; Chazaud, Bénédicte</creator><creatorcontrib>Saclier, Marielle ; Yacoub‐Youssef, Houda ; Mackey, Abigail L. ; Arnold, Ludovic ; Ardjoune, Hamida ; Magnan, Mélanie ; Sailhan, Frédéric ; Chelly, Jamel ; Pavlath, Grace K. ; Mounier, Rémi ; Kjaer, Michael ; Chazaud, Bénédicte</creatorcontrib><description>Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here, we explored both in vitro and in vivo, in human, the interactions of differentially activated MPs with myogenic precursor cells (MPCs) during adult myogenesis and skeletal muscle regeneration. We showed in vitro that through the differential secretion of cytokines and growth factors, proinflammatory MPs inhibited MPC fusion while anti‐inflammatory MPs strongly promoted MPC differentiation by increasing their commitment into differentiated myocytes and the formation of mature myotubes. Furthermore, the in vivo time course of expression of myogenic and MP markers was studied in regenerating human healthy muscle after damage. We observed that regenerating areas containing proliferating MPCs were preferentially associated with MPs expressing proinflammatory markers. In the same muscle, regenerating areas containing differentiating myogenin‐positive MPCs were preferentially coupled to MPs harboring anti‐inflammatory markers. These data demonstrate for the first time in human that MPs sequentially orchestrate adult myogenesis during regeneration of damaged skeletal muscle. These results support the emerging concept that inflammation, through MP activation, controls stem cell fate and coordinates tissue repair. STEM CELLS2013;31:384–396</description><identifier>ISSN: 1066-5099</identifier><identifier>ISSN: 1066-6099</identifier><identifier>EISSN: 1549-4918</identifier><identifier>DOI: 10.1002/stem.1288</identifier><identifier>PMID: 23169615</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Adult Stem Cells - cytology ; Adult Stem Cells - metabolism ; Biomarkers - metabolism ; Cell Differentiation ; Cells, Cultured ; Cellular Biology ; Cytokines - biosynthesis ; Cytokines - secretion ; Gene Expression ; Humans ; Inflammation ; Intercellular Signaling Peptides and Proteins - biosynthesis ; Intercellular Signaling Peptides and Proteins - secretion ; Life Sciences ; Macrophage ; Macrophage Activation ; Macrophages - classification ; Macrophages - cytology ; Macrophages - metabolism ; Muscle Development - physiology ; Muscle Fibers, Skeletal - cytology ; Muscle Fibers, Skeletal - metabolism ; Muscle stem cells ; Muscle, Skeletal - cytology ; Muscle, Skeletal - metabolism ; Muscular system ; Musculoskeletal system ; Myogenesis ; Myogenic precursor ; Myogenin - genetics ; Myogenin - metabolism ; Proteins ; Regeneration - physiology ; Skeletal muscle</subject><ispartof>Stem cells (Dayton, Ohio), 2013-02, Vol.31 (2), p.384-396</ispartof><rights>Copyright © 2012 AlphaMed Press</rights><rights>Copyright © 2012 AlphaMed Press.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5648-c91553cf424c7c0ec8842378b0cb7531fb43b8e5166ea87ae15e5265c0366a9b3</citedby><cites>FETCH-LOGICAL-c5648-c91553cf424c7c0ec8842378b0cb7531fb43b8e5166ea87ae15e5265c0366a9b3</cites><orcidid>0000-0002-5194-682X ; 0000-0003-3464-3322 ; 0000-0001-5351-4775 ; 0000-0002-1262-502X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23169615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00787108$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Saclier, Marielle</creatorcontrib><creatorcontrib>Yacoub‐Youssef, Houda</creatorcontrib><creatorcontrib>Mackey, Abigail L.</creatorcontrib><creatorcontrib>Arnold, Ludovic</creatorcontrib><creatorcontrib>Ardjoune, Hamida</creatorcontrib><creatorcontrib>Magnan, Mélanie</creatorcontrib><creatorcontrib>Sailhan, Frédéric</creatorcontrib><creatorcontrib>Chelly, Jamel</creatorcontrib><creatorcontrib>Pavlath, Grace K.</creatorcontrib><creatorcontrib>Mounier, Rémi</creatorcontrib><creatorcontrib>Kjaer, Michael</creatorcontrib><creatorcontrib>Chazaud, Bénédicte</creatorcontrib><title>Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration</title><title>Stem cells (Dayton, Ohio)</title><addtitle>Stem Cells</addtitle><description>Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here, we explored both in vitro and in vivo, in human, the interactions of differentially activated MPs with myogenic precursor cells (MPCs) during adult myogenesis and skeletal muscle regeneration. We showed in vitro that through the differential secretion of cytokines and growth factors, proinflammatory MPs inhibited MPC fusion while anti‐inflammatory MPs strongly promoted MPC differentiation by increasing their commitment into differentiated myocytes and the formation of mature myotubes. Furthermore, the in vivo time course of expression of myogenic and MP markers was studied in regenerating human healthy muscle after damage. We observed that regenerating areas containing proliferating MPCs were preferentially associated with MPs expressing proinflammatory markers. In the same muscle, regenerating areas containing differentiating myogenin‐positive MPCs were preferentially coupled to MPs harboring anti‐inflammatory markers. These data demonstrate for the first time in human that MPs sequentially orchestrate adult myogenesis during regeneration of damaged skeletal muscle. These results support the emerging concept that inflammation, through MP activation, controls stem cell fate and coordinates tissue repair. STEM CELLS2013;31:384–396</description><subject>Adult</subject><subject>Adult Stem Cells - cytology</subject><subject>Adult Stem Cells - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Cellular Biology</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - secretion</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intercellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Intercellular Signaling Peptides and Proteins - secretion</subject><subject>Life Sciences</subject><subject>Macrophage</subject><subject>Macrophage Activation</subject><subject>Macrophages - classification</subject><subject>Macrophages - cytology</subject><subject>Macrophages - metabolism</subject><subject>Muscle Development - physiology</subject><subject>Muscle Fibers, Skeletal - cytology</subject><subject>Muscle Fibers, Skeletal - metabolism</subject><subject>Muscle stem cells</subject><subject>Muscle, Skeletal - cytology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular system</subject><subject>Musculoskeletal system</subject><subject>Myogenesis</subject><subject>Myogenic precursor</subject><subject>Myogenin - genetics</subject><subject>Myogenin - metabolism</subject><subject>Proteins</subject><subject>Regeneration - physiology</subject><subject>Skeletal muscle</subject><issn>1066-5099</issn><issn>1066-6099</issn><issn>1549-4918</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EakvbAy-ALHEBibR2YjuT42rbski7akXL2XLcya6Lkyx20mrfHoctPSAhTh5pvvnkf4aQd5ydccby8zhge8ZzgFfkiEtRZaLi8DrVTKlMsqo6JG9jfGCMCwlwQA7zgqtKcXlEni5c02DAbnDG-x2d2cE9mgHv6crY0G83Zo2RXge7wTiE1KCrXb_Gzll6E9COIfaBztF7ejU1L8bgujVdjK3p6O0P9DgYT1djtB7pN0yDmCSu707Im8b4iKfP7zH5fnV5N19ky-svX-ezZWalEpDZiktZ2EbkwpaWoQUQeVFCzWxdyoI3tShqQMmVQgOlQS5R5kpaVihlqro4Jp_33o3xehtca8JO98bpxWypXRcxtJqxEkrO4JEn_OMe34b-55gi69ZFm-KZDvsxai4KwdKiBfwfzaEEkErmCf3wF_rQj6FLuSdKSVkKPgk_7am09xgDNi__5UxPd9bTnaeJiX3_bBzrFu9fyD-HTcD5HnhyHnf_Nunbu8vVb-Uv_qmx1w</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Saclier, Marielle</creator><creator>Yacoub‐Youssef, Houda</creator><creator>Mackey, Abigail L.</creator><creator>Arnold, Ludovic</creator><creator>Ardjoune, Hamida</creator><creator>Magnan, Mélanie</creator><creator>Sailhan, Frédéric</creator><creator>Chelly, Jamel</creator><creator>Pavlath, Grace K.</creator><creator>Mounier, Rémi</creator><creator>Kjaer, Michael</creator><creator>Chazaud, Bénédicte</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Oxford University Press</general><general>Alphamed Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-5194-682X</orcidid><orcidid>https://orcid.org/0000-0003-3464-3322</orcidid><orcidid>https://orcid.org/0000-0001-5351-4775</orcidid><orcidid>https://orcid.org/0000-0002-1262-502X</orcidid></search><sort><creationdate>201302</creationdate><title>Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration</title><author>Saclier, Marielle ; Yacoub‐Youssef, Houda ; Mackey, Abigail L. ; Arnold, Ludovic ; Ardjoune, Hamida ; Magnan, Mélanie ; Sailhan, Frédéric ; Chelly, Jamel ; Pavlath, Grace K. ; Mounier, Rémi ; Kjaer, Michael ; Chazaud, Bénédicte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5648-c91553cf424c7c0ec8842378b0cb7531fb43b8e5166ea87ae15e5265c0366a9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adult Stem Cells - cytology</topic><topic>Adult Stem Cells - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Cellular Biology</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - secretion</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intercellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Intercellular Signaling Peptides and Proteins - secretion</topic><topic>Life Sciences</topic><topic>Macrophage</topic><topic>Macrophage Activation</topic><topic>Macrophages - classification</topic><topic>Macrophages - cytology</topic><topic>Macrophages - metabolism</topic><topic>Muscle Development - physiology</topic><topic>Muscle Fibers, Skeletal - cytology</topic><topic>Muscle Fibers, Skeletal - metabolism</topic><topic>Muscle stem cells</topic><topic>Muscle, Skeletal - cytology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular system</topic><topic>Musculoskeletal system</topic><topic>Myogenesis</topic><topic>Myogenic precursor</topic><topic>Myogenin - genetics</topic><topic>Myogenin - metabolism</topic><topic>Proteins</topic><topic>Regeneration - physiology</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saclier, Marielle</creatorcontrib><creatorcontrib>Yacoub‐Youssef, Houda</creatorcontrib><creatorcontrib>Mackey, Abigail L.</creatorcontrib><creatorcontrib>Arnold, Ludovic</creatorcontrib><creatorcontrib>Ardjoune, Hamida</creatorcontrib><creatorcontrib>Magnan, Mélanie</creatorcontrib><creatorcontrib>Sailhan, Frédéric</creatorcontrib><creatorcontrib>Chelly, Jamel</creatorcontrib><creatorcontrib>Pavlath, Grace K.</creatorcontrib><creatorcontrib>Mounier, Rémi</creatorcontrib><creatorcontrib>Kjaer, Michael</creatorcontrib><creatorcontrib>Chazaud, Bénédicte</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Stem cells (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saclier, Marielle</au><au>Yacoub‐Youssef, Houda</au><au>Mackey, Abigail L.</au><au>Arnold, Ludovic</au><au>Ardjoune, Hamida</au><au>Magnan, Mélanie</au><au>Sailhan, Frédéric</au><au>Chelly, Jamel</au><au>Pavlath, Grace K.</au><au>Mounier, Rémi</au><au>Kjaer, Michael</au><au>Chazaud, Bénédicte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration</atitle><jtitle>Stem cells (Dayton, Ohio)</jtitle><addtitle>Stem Cells</addtitle><date>2013-02</date><risdate>2013</risdate><volume>31</volume><issue>2</issue><spage>384</spage><epage>396</epage><pages>384-396</pages><issn>1066-5099</issn><issn>1066-6099</issn><eissn>1549-4918</eissn><abstract>Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here, we explored both in vitro and in vivo, in human, the interactions of differentially activated MPs with myogenic precursor cells (MPCs) during adult myogenesis and skeletal muscle regeneration. We showed in vitro that through the differential secretion of cytokines and growth factors, proinflammatory MPs inhibited MPC fusion while anti‐inflammatory MPs strongly promoted MPC differentiation by increasing their commitment into differentiated myocytes and the formation of mature myotubes. Furthermore, the in vivo time course of expression of myogenic and MP markers was studied in regenerating human healthy muscle after damage. We observed that regenerating areas containing proliferating MPCs were preferentially associated with MPs expressing proinflammatory markers. In the same muscle, regenerating areas containing differentiating myogenin‐positive MPCs were preferentially coupled to MPs harboring anti‐inflammatory markers. These data demonstrate for the first time in human that MPs sequentially orchestrate adult myogenesis during regeneration of damaged skeletal muscle. These results support the emerging concept that inflammation, through MP activation, controls stem cell fate and coordinates tissue repair. STEM CELLS2013;31:384–396</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23169615</pmid><doi>10.1002/stem.1288</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-5194-682X</orcidid><orcidid>https://orcid.org/0000-0003-3464-3322</orcidid><orcidid>https://orcid.org/0000-0001-5351-4775</orcidid><orcidid>https://orcid.org/0000-0002-1262-502X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1066-5099 |
| ispartof | Stem cells (Dayton, Ohio), 2013-02, Vol.31 (2), p.384-396 |
| issn | 1066-5099 1066-6099 1549-4918 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_00787108v1 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Adult Stem Cells - cytology Adult Stem Cells - metabolism Biomarkers - metabolism Cell Differentiation Cells, Cultured Cellular Biology Cytokines - biosynthesis Cytokines - secretion Gene Expression Humans Inflammation Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - secretion Life Sciences Macrophage Macrophage Activation Macrophages - classification Macrophages - cytology Macrophages - metabolism Muscle Development - physiology Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism Muscle stem cells Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscular system Musculoskeletal system Myogenesis Myogenic precursor Myogenin - genetics Myogenin - metabolism Proteins Regeneration - physiology Skeletal muscle |
| title | Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T12%3A34%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differentially%20Activated%20Macrophages%20Orchestrate%20Myogenic%20Precursor%20Cell%20Fate%20During%20Human%20Skeletal%20Muscle%20Regeneration&rft.jtitle=Stem%20cells%20(Dayton,%20Ohio)&rft.au=Saclier,%20Marielle&rft.date=2013-02&rft.volume=31&rft.issue=2&rft.spage=384&rft.epage=396&rft.pages=384-396&rft.issn=1066-5099&rft.eissn=1549-4918&rft_id=info:doi/10.1002/stem.1288&rft_dat=%3Cproquest_hal_p%3E1287885652%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1286557418&rft_id=info:pmid/23169615&rfr_iscdi=true |