Depot-specific regulation of autotaxin with obesity in human adipose tissue

Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resi...

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Veröffentlicht in:	Journal of physiology and biochemistry 2012-12, Vol.68 (4), p.635-644
Hauptverfasser:	Rancoule, Chloé, Dusaulcy, Rodolphe, Tréguer, Karine, Grès, Sandra, Guigné, Charlotte, Quilliot, Didier, Valet, Philippe, Saulnier-Blache, Jean Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animal Physiology Biomedical and Life Sciences Biomedicine Blood Pressure Case-Control Studies Female Gene Expression Regulation Human Physiology Humans Intra-Abdominal Fat - metabolism Leptin - genetics Leptin - metabolism Obesity - metabolism Obesity - physiopathology Organ Specificity Original Paper Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Subcutaneous Fat - metabolism Up-Regulation
Online-Zugang:	Volltext
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