Depot-specific regulation of autotaxin with obesity in human adipose tissue

Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resi...

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Veröffentlicht in:	Journal of physiology and biochemistry 2012-12, Vol.68 (4), p.635-644
Hauptverfasser:	Rancoule, Chloé, Dusaulcy, Rodolphe, Tréguer, Karine, Grès, Sandra, Guigné, Charlotte, Quilliot, Didier, Valet, Philippe, Saulnier-Blache, Jean Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animal Physiology Biomedical and Life Sciences Biomedicine Blood Pressure Case-Control Studies Female Gene Expression Regulation Human Physiology Humans Intra-Abdominal Fat - metabolism Leptin - genetics Leptin - metabolism Obesity - metabolism Obesity - physiopathology Organ Specificity Original Paper Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Subcutaneous Fat - metabolism Up-Regulation
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Beschreibung
Zusammenfassung:	Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resistance. In the present study, fat depot-specific regulation of ATX was explored in human. ATX mRNA expression was quantified in visceral and subcutaneous adipose tissue in obese (BMI > 40 kg/m 2 ; n = 27) and non-obese patients (BMI
ISSN:	1138-7548 1877-8755
DOI:	10.1007/s13105-012-0181-z