Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with (188)Re-lipid nanocapsules
To date, glioblastoma treatments have only been palliative. In this context, locoregional drug delivery strategies, which allow for blood--brain barrier bypass and reduced systemic toxicity, are of major significance. Recent progress in nanotechnology has led to the development of colloidal carriers...
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Veröffentlicht in: | Biomaterials 2011-10, Vol.32 (28), p.6781-90 |
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creator | Vanpouille-Box, Claire Lacoeuille, Franck Belloche, Camille Lepareur, Nicolas Lemaire, Laurent LeJeune, Jean-Jacques Benoît, Jean-Pierre Menei, Philippe Couturier, Olivier F Garcion, Emmanuel Hindré, François |
description | To date, glioblastoma treatments have only been palliative. In this context, locoregional drug delivery strategies, which allow for blood--brain barrier bypass and reduced systemic toxicity, are of major significance. Recent progress in nanotechnology has led to the development of colloidal carriers of radiopharmaceutics, such as lipid nanocapsules loaded with rhenium-188 (LNC(188)Re-SSS) that are implanted in the brain. In our study, we demonstrated that fractionated internal radiation using LNC(188)Re-SSS triggered remarkable survival responses in a rat orthotopic glioma model (cure rates of 83%). We also highlighted the importance of the radioactivity activity gradient obtained by combining a simple stereotactic injection (SI) with convection-enhanced delivery (CED).We assumed that the immune system played a role in the treatment's efficacy on account of the overproduction of peripheral cytokines, recruitment of immune cells to the tumor site, and memory response in long-term survivor animals. Hence, nanovectorized internal radiation therapy with activity gradients stimulating immune responses may represent a new and interesting alternative for the treatment of solid tumors such as glioblastomas. |
doi_str_mv | 10.1016/j.biomaterials.2011.05.067 |
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In this context, locoregional drug delivery strategies, which allow for blood--brain barrier bypass and reduced systemic toxicity, are of major significance. Recent progress in nanotechnology has led to the development of colloidal carriers of radiopharmaceutics, such as lipid nanocapsules loaded with rhenium-188 (LNC(188)Re-SSS) that are implanted in the brain. In our study, we demonstrated that fractionated internal radiation using LNC(188)Re-SSS triggered remarkable survival responses in a rat orthotopic glioma model (cure rates of 83%). We also highlighted the importance of the radioactivity activity gradient obtained by combining a simple stereotactic injection (SI) with convection-enhanced delivery (CED).We assumed that the immune system played a role in the treatment's efficacy on account of the overproduction of peripheral cytokines, recruitment of immune cells to the tumor site, and memory response in long-term survivor animals. Hence, nanovectorized internal radiation therapy with activity gradients stimulating immune responses may represent a new and interesting alternative for the treatment of solid tumors such as glioblastomas.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2011.05.067</identifier><identifier>PMID: 21705077</identifier><language>eng</language><publisher>Netherlands: Elsevier</publisher><subject>Animals ; Bioengineering ; Biomaterials ; Biotechnology ; Brain Neoplasms - immunology ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Cell Line, Tumor ; Computer Science ; Drug Carriers - chemistry ; Drug Carriers - metabolism ; Drug Delivery Systems ; Female ; Glioma - immunology ; Glioma - mortality ; Glioma - pathology ; Glioma - radiotherapy ; Immunosuppression ; Isotope Labeling ; Life Sciences ; Lipids ; Lipids - chemistry ; Liposomes ; Materials Testing ; Nanocapsules ; Nanocapsules - chemistry ; Particle Size ; Pharmaceutical sciences ; Radioisotopes ; Radioisotopes - chemistry ; Radioisotopes - metabolism ; Radioisotopes - therapeutic use ; Rats ; Rats, Inbred F344 ; Rhenium - chemistry ; Rhenium - metabolism ; Rhenium - therapeutic use ; Survival Rate ; Survivors ; Tissue Distribution</subject><ispartof>Biomaterials, 2011-10, Vol.32 (28), p.6781-90</ispartof><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7070-7664 ; 0000-0001-9860-5451 ; 0000-0003-0887-272X ; 0000-0002-1308-9345</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21705077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00638699$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanpouille-Box, Claire</creatorcontrib><creatorcontrib>Lacoeuille, Franck</creatorcontrib><creatorcontrib>Belloche, Camille</creatorcontrib><creatorcontrib>Lepareur, Nicolas</creatorcontrib><creatorcontrib>Lemaire, Laurent</creatorcontrib><creatorcontrib>LeJeune, Jean-Jacques</creatorcontrib><creatorcontrib>Benoît, Jean-Pierre</creatorcontrib><creatorcontrib>Menei, Philippe</creatorcontrib><creatorcontrib>Couturier, Olivier F</creatorcontrib><creatorcontrib>Garcion, Emmanuel</creatorcontrib><creatorcontrib>Hindré, François</creatorcontrib><title>Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with (188)Re-lipid nanocapsules</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>To date, glioblastoma treatments have only been palliative. In this context, locoregional drug delivery strategies, which allow for blood--brain barrier bypass and reduced systemic toxicity, are of major significance. Recent progress in nanotechnology has led to the development of colloidal carriers of radiopharmaceutics, such as lipid nanocapsules loaded with rhenium-188 (LNC(188)Re-SSS) that are implanted in the brain. In our study, we demonstrated that fractionated internal radiation using LNC(188)Re-SSS triggered remarkable survival responses in a rat orthotopic glioma model (cure rates of 83%). We also highlighted the importance of the radioactivity activity gradient obtained by combining a simple stereotactic injection (SI) with convection-enhanced delivery (CED).We assumed that the immune system played a role in the treatment's efficacy on account of the overproduction of peripheral cytokines, recruitment of immune cells to the tumor site, and memory response in long-term survivor animals. Hence, nanovectorized internal radiation therapy with activity gradients stimulating immune responses may represent a new and interesting alternative for the treatment of solid tumors such as glioblastomas.</description><subject>Animals</subject><subject>Bioengineering</subject><subject>Biomaterials</subject><subject>Biotechnology</subject><subject>Brain Neoplasms - immunology</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Cell Line, Tumor</subject><subject>Computer Science</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - metabolism</subject><subject>Drug Delivery Systems</subject><subject>Female</subject><subject>Glioma - immunology</subject><subject>Glioma - mortality</subject><subject>Glioma - pathology</subject><subject>Glioma - radiotherapy</subject><subject>Immunosuppression</subject><subject>Isotope Labeling</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Liposomes</subject><subject>Materials Testing</subject><subject>Nanocapsules</subject><subject>Nanocapsules - chemistry</subject><subject>Particle Size</subject><subject>Pharmaceutical sciences</subject><subject>Radioisotopes</subject><subject>Radioisotopes - chemistry</subject><subject>Radioisotopes - metabolism</subject><subject>Radioisotopes - therapeutic use</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rhenium - chemistry</subject><subject>Rhenium - metabolism</subject><subject>Rhenium - therapeutic use</subject><subject>Survival Rate</subject><subject>Survivors</subject><subject>Tissue Distribution</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo7vrxFyR4UrA1kzZpclxEXWFBED2XaZvuZmnTkrQre_SfW1n1NMzM-z7zQcg1sBgYyPttXNiuxcF4i02IOQOImYiZzI7IHFSmIqGZOCZzBimPtAQ-I2chbNmUs5SfkhmHjAmWZXPy9T62nafGY2VLHGznqHXU40DXzc8Qiq6ixb7HEGhXU9u2o-vC2PfehGB3hhbovTU-0DFYt57M01oOG_oDPPA-7bChN6DU7ZuJGtvbijp0XYl9GBsTLshJPZ1hLn_jOfl4enx_WEar1-eXh8Uq2oDkQ8QFS0QmNAhExUrQaaKLGqea5pWWCo3mvAREXoraqKkHskxTmWQyVRXK5JzcHbgbbPLe2xb9Pu_Q5svFKrcuGN_mjMlESa13MMmvDvJ-LFpT_Tv-Xpd8A5uAdlk</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Vanpouille-Box, Claire</creator><creator>Lacoeuille, Franck</creator><creator>Belloche, Camille</creator><creator>Lepareur, Nicolas</creator><creator>Lemaire, Laurent</creator><creator>LeJeune, Jean-Jacques</creator><creator>Benoît, Jean-Pierre</creator><creator>Menei, Philippe</creator><creator>Couturier, Olivier F</creator><creator>Garcion, Emmanuel</creator><creator>Hindré, François</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-7070-7664</orcidid><orcidid>https://orcid.org/0000-0001-9860-5451</orcidid><orcidid>https://orcid.org/0000-0003-0887-272X</orcidid><orcidid>https://orcid.org/0000-0002-1308-9345</orcidid></search><sort><creationdate>201110</creationdate><title>Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with (188)Re-lipid nanocapsules</title><author>Vanpouille-Box, Claire ; Lacoeuille, Franck ; Belloche, Camille ; Lepareur, Nicolas ; Lemaire, Laurent ; LeJeune, Jean-Jacques ; Benoît, Jean-Pierre ; Menei, Philippe ; Couturier, Olivier F ; Garcion, Emmanuel ; Hindré, François</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h162t-2503575915aa80c19439bfa35792d968ae922c1aa2c5fe89bf16c44637648da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Bioengineering</topic><topic>Biomaterials</topic><topic>Biotechnology</topic><topic>Brain Neoplasms - immunology</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Cell Line, Tumor</topic><topic>Computer Science</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - metabolism</topic><topic>Drug Delivery Systems</topic><topic>Female</topic><topic>Glioma - immunology</topic><topic>Glioma - mortality</topic><topic>Glioma - pathology</topic><topic>Glioma - radiotherapy</topic><topic>Immunosuppression</topic><topic>Isotope Labeling</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Lipids - chemistry</topic><topic>Liposomes</topic><topic>Materials Testing</topic><topic>Nanocapsules</topic><topic>Nanocapsules - chemistry</topic><topic>Particle Size</topic><topic>Pharmaceutical sciences</topic><topic>Radioisotopes</topic><topic>Radioisotopes - chemistry</topic><topic>Radioisotopes - metabolism</topic><topic>Radioisotopes - therapeutic use</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rhenium - chemistry</topic><topic>Rhenium - metabolism</topic><topic>Rhenium - therapeutic use</topic><topic>Survival Rate</topic><topic>Survivors</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vanpouille-Box, Claire</creatorcontrib><creatorcontrib>Lacoeuille, Franck</creatorcontrib><creatorcontrib>Belloche, Camille</creatorcontrib><creatorcontrib>Lepareur, Nicolas</creatorcontrib><creatorcontrib>Lemaire, Laurent</creatorcontrib><creatorcontrib>LeJeune, Jean-Jacques</creatorcontrib><creatorcontrib>Benoît, Jean-Pierre</creatorcontrib><creatorcontrib>Menei, Philippe</creatorcontrib><creatorcontrib>Couturier, Olivier F</creatorcontrib><creatorcontrib>Garcion, Emmanuel</creatorcontrib><creatorcontrib>Hindré, François</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vanpouille-Box, Claire</au><au>Lacoeuille, Franck</au><au>Belloche, Camille</au><au>Lepareur, Nicolas</au><au>Lemaire, Laurent</au><au>LeJeune, Jean-Jacques</au><au>Benoît, Jean-Pierre</au><au>Menei, Philippe</au><au>Couturier, Olivier F</au><au>Garcion, Emmanuel</au><au>Hindré, François</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with (188)Re-lipid nanocapsules</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2011-10</date><risdate>2011</risdate><volume>32</volume><issue>28</issue><spage>6781</spage><epage>90</epage><pages>6781-90</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>To date, glioblastoma treatments have only been palliative. In this context, locoregional drug delivery strategies, which allow for blood--brain barrier bypass and reduced systemic toxicity, are of major significance. Recent progress in nanotechnology has led to the development of colloidal carriers of radiopharmaceutics, such as lipid nanocapsules loaded with rhenium-188 (LNC(188)Re-SSS) that are implanted in the brain. In our study, we demonstrated that fractionated internal radiation using LNC(188)Re-SSS triggered remarkable survival responses in a rat orthotopic glioma model (cure rates of 83%). We also highlighted the importance of the radioactivity activity gradient obtained by combining a simple stereotactic injection (SI) with convection-enhanced delivery (CED).We assumed that the immune system played a role in the treatment's efficacy on account of the overproduction of peripheral cytokines, recruitment of immune cells to the tumor site, and memory response in long-term survivor animals. Hence, nanovectorized internal radiation therapy with activity gradients stimulating immune responses may represent a new and interesting alternative for the treatment of solid tumors such as glioblastomas.</abstract><cop>Netherlands</cop><pub>Elsevier</pub><pmid>21705077</pmid><doi>10.1016/j.biomaterials.2011.05.067</doi><tpages>-6690</tpages><orcidid>https://orcid.org/0000-0002-7070-7664</orcidid><orcidid>https://orcid.org/0000-0001-9860-5451</orcidid><orcidid>https://orcid.org/0000-0003-0887-272X</orcidid><orcidid>https://orcid.org/0000-0002-1308-9345</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Bioengineering Biomaterials Biotechnology Brain Neoplasms - immunology Brain Neoplasms - mortality Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cell Line, Tumor Computer Science Drug Carriers - chemistry Drug Carriers - metabolism Drug Delivery Systems Female Glioma - immunology Glioma - mortality Glioma - pathology Glioma - radiotherapy Immunosuppression Isotope Labeling Life Sciences Lipids Lipids - chemistry Liposomes Materials Testing Nanocapsules Nanocapsules - chemistry Particle Size Pharmaceutical sciences Radioisotopes Radioisotopes - chemistry Radioisotopes - metabolism Radioisotopes - therapeutic use Rats Rats, Inbred F344 Rhenium - chemistry Rhenium - metabolism Rhenium - therapeutic use Survival Rate Survivors Tissue Distribution |
title | Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with (188)Re-lipid nanocapsules |
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