Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish
Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. Because chemokines, notably CXCL12, and their receptors, such as CXCR4, play key roles in...
Gespeichert in:
| Veröffentlicht in: | Journal of comparative neurology (1911) 2010-12, Vol.518 (24), p.4855-4876 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4876 |
|---|---|
| container_issue | 24 |
| container_start_page | 4855 |
| container_title | Journal of comparative neurology (1911) |
| container_volume | 518 |
| creator | Diotel, Nicolas Vaillant, Colette Gueguen, Marie-Madeleine Mironov, Svetlana Anglade, Isabelle Servili, Arianna Pellegrini, Elisabeth Kah, Olivier |
| description | Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. Because chemokines, notably CXCL12, and their receptors, such as CXCR4, play key roles in mammalian embryonic neurogenesis, we investigated Cxcr4 and Cxcl12 expressions in the brain of adult zebrafish and their potential relationships with cell proliferation. Cxcr4 expression was found to be restricted to radial glial cells in the adult zebrafish, where it is co‐expressed with established radial glial cell markers, such as brain lipid‐binding protein (Blbp) or the estrogen‐synthesizing enzyme aromatase B (Cyp19a1b). Double stainings combining proliferating cell nuclear antigen (PCNA) and Cxcr4 immunolabelling indicated that there is no obvious association between Cxcr4 expression and radial glial cell proliferation. Interestingly, cxcl12a messengers were detected in ventricular regions, in cells corresponding to aromatase B‐immunoreactive radial glial cells. Altogether, our data demonstrate Cxcl12 and Cxcr4 expression in radial glial cells of the brain of adult zebrafish, supporting important roles for the Cxcl12/Cxcr4 pair in brain development and functioning. J. Comp. Neurol. 518:4855–4876, 2010. © 2010 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/cne.22492 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_inserm_00590787v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>879477094</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6292-1488d42f7a47102bf4338d54ded09e97720a6aab8c64bd587f7d013915ecf91f3</originalsourceid><addsrcrecordid>eNqNkl1rFDEUhoModq1e-Ack4IUITntOJpOPy7L0Q9huKSiCNyE7ybipszNrsqNbf71Zp92LgtSbJCfnOS_kzUvIa4QjBGDHdeePGOOaPSETBC0KrQQ-JZPcw0JrIQ_Ii5RuAEDrUj0nBwyhxKoSE3I93daRU9s5mk8tMuq36-hTCn1HQ0ejdcG29Fu7W2vfton2Dd0sPV1Em_u5sG5oN_S3zxdNSMuX5Flj2-Rf3e2H5PPZ6afpRTG7Ov84PZkVtWCaFciVcpw10nKJwBYNL0vlKu68A-21lAyssHahasEXrlKykQ6w1Fj5utHYlIfkw6i7tK1Zx7Cy8db0NpiLk5kJXfJxZQAqDVLJn5jxdyO-jv2PwaeNWYW0e5DtfD8ko5RCUEyI_yBLQF5B9TgpNZcSNH-UlIJlG_KfZPLtA_KmH2KXnTQohVDIJKhMvR-pOvYpRd_sHUAwu0yYnAnzNxOZfXOnOCxW3u3J-xBk4HgEfoXW3_5byUznp_eSxTgR0sZv9xM2fjdClrIyX-bn5gyvv84vL-eGl38Amq_K9A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1766812708</pqid></control><display><type>article</type><title>Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Diotel, Nicolas ; Vaillant, Colette ; Gueguen, Marie-Madeleine ; Mironov, Svetlana ; Anglade, Isabelle ; Servili, Arianna ; Pellegrini, Elisabeth ; Kah, Olivier</creator><creatorcontrib>Diotel, Nicolas ; Vaillant, Colette ; Gueguen, Marie-Madeleine ; Mironov, Svetlana ; Anglade, Isabelle ; Servili, Arianna ; Pellegrini, Elisabeth ; Kah, Olivier</creatorcontrib><description>Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. Because chemokines, notably CXCL12, and their receptors, such as CXCR4, play key roles in mammalian embryonic neurogenesis, we investigated Cxcr4 and Cxcl12 expressions in the brain of adult zebrafish and their potential relationships with cell proliferation. Cxcr4 expression was found to be restricted to radial glial cells in the adult zebrafish, where it is co‐expressed with established radial glial cell markers, such as brain lipid‐binding protein (Blbp) or the estrogen‐synthesizing enzyme aromatase B (Cyp19a1b). Double stainings combining proliferating cell nuclear antigen (PCNA) and Cxcr4 immunolabelling indicated that there is no obvious association between Cxcr4 expression and radial glial cell proliferation. Interestingly, cxcl12a messengers were detected in ventricular regions, in cells corresponding to aromatase B‐immunoreactive radial glial cells. Altogether, our data demonstrate Cxcl12 and Cxcr4 expression in radial glial cells of the brain of adult zebrafish, supporting important roles for the Cxcl12/Cxcr4 pair in brain development and functioning. J. Comp. Neurol. 518:4855–4876, 2010. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0021-9967</identifier><identifier>ISSN: 1096-9861</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.22492</identifier><identifier>PMID: 21031556</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; aromatase ; Aromatase - biosynthesis ; Aromatase - genetics ; Biochemistry, Molecular Biology ; Biomarkers - metabolism ; Brain - cytology ; Brain - metabolism ; Cell Proliferation ; chemokine ; Chemokine CXCL12 - biosynthesis ; Chemokine CXCL12 - genetics ; chemokine receptor ; Danio rerio ; Fatty Acid-Binding Proteins - biosynthesis ; Fatty Acid-Binding Proteins - genetics ; Freshwater ; Life Sciences ; Neural Stem Cells - cytology ; Neural Stem Cells - metabolism ; neurogenesis ; Neurogenesis - genetics ; Neuroglia - cytology ; Neuroglia - metabolism ; Neuronal Plasticity - genetics ; Proliferating Cell Nuclear Antigen - physiology ; radial glia ; Receptors, CXCR4 - biosynthesis ; Receptors, CXCR4 - genetics ; teleost ; Teleostei ; Zebrafish ; Zebrafish Proteins - biosynthesis ; Zebrafish Proteins - genetics</subject><ispartof>Journal of comparative neurology (1911), 2010-12, Vol.518 (24), p.4855-4876</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2010 Wiley-Liss, Inc.</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6292-1488d42f7a47102bf4338d54ded09e97720a6aab8c64bd587f7d013915ecf91f3</citedby><cites>FETCH-LOGICAL-c6292-1488d42f7a47102bf4338d54ded09e97720a6aab8c64bd587f7d013915ecf91f3</cites><orcidid>0000-0002-6813-7500 ; 0000-0003-4821-0966 ; 0000-0003-2032-518X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcne.22492$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcne.22492$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21031556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00590787$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Diotel, Nicolas</creatorcontrib><creatorcontrib>Vaillant, Colette</creatorcontrib><creatorcontrib>Gueguen, Marie-Madeleine</creatorcontrib><creatorcontrib>Mironov, Svetlana</creatorcontrib><creatorcontrib>Anglade, Isabelle</creatorcontrib><creatorcontrib>Servili, Arianna</creatorcontrib><creatorcontrib>Pellegrini, Elisabeth</creatorcontrib><creatorcontrib>Kah, Olivier</creatorcontrib><title>Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. Because chemokines, notably CXCL12, and their receptors, such as CXCR4, play key roles in mammalian embryonic neurogenesis, we investigated Cxcr4 and Cxcl12 expressions in the brain of adult zebrafish and their potential relationships with cell proliferation. Cxcr4 expression was found to be restricted to radial glial cells in the adult zebrafish, where it is co‐expressed with established radial glial cell markers, such as brain lipid‐binding protein (Blbp) or the estrogen‐synthesizing enzyme aromatase B (Cyp19a1b). Double stainings combining proliferating cell nuclear antigen (PCNA) and Cxcr4 immunolabelling indicated that there is no obvious association between Cxcr4 expression and radial glial cell proliferation. Interestingly, cxcl12a messengers were detected in ventricular regions, in cells corresponding to aromatase B‐immunoreactive radial glial cells. Altogether, our data demonstrate Cxcl12 and Cxcr4 expression in radial glial cells of the brain of adult zebrafish, supporting important roles for the Cxcl12/Cxcr4 pair in brain development and functioning. J. Comp. Neurol. 518:4855–4876, 2010. © 2010 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>aromatase</subject><subject>Aromatase - biosynthesis</subject><subject>Aromatase - genetics</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biomarkers - metabolism</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Cell Proliferation</subject><subject>chemokine</subject><subject>Chemokine CXCL12 - biosynthesis</subject><subject>Chemokine CXCL12 - genetics</subject><subject>chemokine receptor</subject><subject>Danio rerio</subject><subject>Fatty Acid-Binding Proteins - biosynthesis</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Freshwater</subject><subject>Life Sciences</subject><subject>Neural Stem Cells - cytology</subject><subject>Neural Stem Cells - metabolism</subject><subject>neurogenesis</subject><subject>Neurogenesis - genetics</subject><subject>Neuroglia - cytology</subject><subject>Neuroglia - metabolism</subject><subject>Neuronal Plasticity - genetics</subject><subject>Proliferating Cell Nuclear Antigen - physiology</subject><subject>radial glia</subject><subject>Receptors, CXCR4 - biosynthesis</subject><subject>Receptors, CXCR4 - genetics</subject><subject>teleost</subject><subject>Teleostei</subject><subject>Zebrafish</subject><subject>Zebrafish Proteins - biosynthesis</subject><subject>Zebrafish Proteins - genetics</subject><issn>0021-9967</issn><issn>1096-9861</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl1rFDEUhoModq1e-Ack4IUITntOJpOPy7L0Q9huKSiCNyE7ybipszNrsqNbf71Zp92LgtSbJCfnOS_kzUvIa4QjBGDHdeePGOOaPSETBC0KrQQ-JZPcw0JrIQ_Ii5RuAEDrUj0nBwyhxKoSE3I93daRU9s5mk8tMuq36-hTCn1HQ0ejdcG29Fu7W2vfton2Dd0sPV1Em_u5sG5oN_S3zxdNSMuX5Flj2-Rf3e2H5PPZ6afpRTG7Ov84PZkVtWCaFciVcpw10nKJwBYNL0vlKu68A-21lAyssHahasEXrlKykQ6w1Fj5utHYlIfkw6i7tK1Zx7Cy8db0NpiLk5kJXfJxZQAqDVLJn5jxdyO-jv2PwaeNWYW0e5DtfD8ko5RCUEyI_yBLQF5B9TgpNZcSNH-UlIJlG_KfZPLtA_KmH2KXnTQohVDIJKhMvR-pOvYpRd_sHUAwu0yYnAnzNxOZfXOnOCxW3u3J-xBk4HgEfoXW3_5byUznp_eSxTgR0sZv9xM2fjdClrIyX-bn5gyvv84vL-eGl38Amq_K9A</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Diotel, Nicolas</creator><creator>Vaillant, Colette</creator><creator>Gueguen, Marie-Madeleine</creator><creator>Mironov, Svetlana</creator><creator>Anglade, Isabelle</creator><creator>Servili, Arianna</creator><creator>Pellegrini, Elisabeth</creator><creator>Kah, Olivier</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6813-7500</orcidid><orcidid>https://orcid.org/0000-0003-4821-0966</orcidid><orcidid>https://orcid.org/0000-0003-2032-518X</orcidid></search><sort><creationdate>20101215</creationdate><title>Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish</title><author>Diotel, Nicolas ; Vaillant, Colette ; Gueguen, Marie-Madeleine ; Mironov, Svetlana ; Anglade, Isabelle ; Servili, Arianna ; Pellegrini, Elisabeth ; Kah, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6292-1488d42f7a47102bf4338d54ded09e97720a6aab8c64bd587f7d013915ecf91f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>aromatase</topic><topic>Aromatase - biosynthesis</topic><topic>Aromatase - genetics</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biomarkers - metabolism</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>Cell Proliferation</topic><topic>chemokine</topic><topic>Chemokine CXCL12 - biosynthesis</topic><topic>Chemokine CXCL12 - genetics</topic><topic>chemokine receptor</topic><topic>Danio rerio</topic><topic>Fatty Acid-Binding Proteins - biosynthesis</topic><topic>Fatty Acid-Binding Proteins - genetics</topic><topic>Freshwater</topic><topic>Life Sciences</topic><topic>Neural Stem Cells - cytology</topic><topic>Neural Stem Cells - metabolism</topic><topic>neurogenesis</topic><topic>Neurogenesis - genetics</topic><topic>Neuroglia - cytology</topic><topic>Neuroglia - metabolism</topic><topic>Neuronal Plasticity - genetics</topic><topic>Proliferating Cell Nuclear Antigen - physiology</topic><topic>radial glia</topic><topic>Receptors, CXCR4 - biosynthesis</topic><topic>Receptors, CXCR4 - genetics</topic><topic>teleost</topic><topic>Teleostei</topic><topic>Zebrafish</topic><topic>Zebrafish Proteins - biosynthesis</topic><topic>Zebrafish Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diotel, Nicolas</creatorcontrib><creatorcontrib>Vaillant, Colette</creatorcontrib><creatorcontrib>Gueguen, Marie-Madeleine</creatorcontrib><creatorcontrib>Mironov, Svetlana</creatorcontrib><creatorcontrib>Anglade, Isabelle</creatorcontrib><creatorcontrib>Servili, Arianna</creatorcontrib><creatorcontrib>Pellegrini, Elisabeth</creatorcontrib><creatorcontrib>Kah, Olivier</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diotel, Nicolas</au><au>Vaillant, Colette</au><au>Gueguen, Marie-Madeleine</au><au>Mironov, Svetlana</au><au>Anglade, Isabelle</au><au>Servili, Arianna</au><au>Pellegrini, Elisabeth</au><au>Kah, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. Comp. Neurol</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>518</volume><issue>24</issue><spage>4855</spage><epage>4876</epage><pages>4855-4876</pages><issn>0021-9967</issn><issn>1096-9861</issn><eissn>1096-9861</eissn><abstract>Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of radial glial cells acting as neural progenitors throughout life. Because chemokines, notably CXCL12, and their receptors, such as CXCR4, play key roles in mammalian embryonic neurogenesis, we investigated Cxcr4 and Cxcl12 expressions in the brain of adult zebrafish and their potential relationships with cell proliferation. Cxcr4 expression was found to be restricted to radial glial cells in the adult zebrafish, where it is co‐expressed with established radial glial cell markers, such as brain lipid‐binding protein (Blbp) or the estrogen‐synthesizing enzyme aromatase B (Cyp19a1b). Double stainings combining proliferating cell nuclear antigen (PCNA) and Cxcr4 immunolabelling indicated that there is no obvious association between Cxcr4 expression and radial glial cell proliferation. Interestingly, cxcl12a messengers were detected in ventricular regions, in cells corresponding to aromatase B‐immunoreactive radial glial cells. Altogether, our data demonstrate Cxcl12 and Cxcr4 expression in radial glial cells of the brain of adult zebrafish, supporting important roles for the Cxcl12/Cxcr4 pair in brain development and functioning. J. Comp. Neurol. 518:4855–4876, 2010. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21031556</pmid><doi>10.1002/cne.22492</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-6813-7500</orcidid><orcidid>https://orcid.org/0000-0003-4821-0966</orcidid><orcidid>https://orcid.org/0000-0003-2032-518X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9967 |
| ispartof | Journal of comparative neurology (1911), 2010-12, Vol.518 (24), p.4855-4876 |
| issn | 0021-9967 1096-9861 1096-9861 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_00590787v1 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals aromatase Aromatase - biosynthesis Aromatase - genetics Biochemistry, Molecular Biology Biomarkers - metabolism Brain - cytology Brain - metabolism Cell Proliferation chemokine Chemokine CXCL12 - biosynthesis Chemokine CXCL12 - genetics chemokine receptor Danio rerio Fatty Acid-Binding Proteins - biosynthesis Fatty Acid-Binding Proteins - genetics Freshwater Life Sciences Neural Stem Cells - cytology Neural Stem Cells - metabolism neurogenesis Neurogenesis - genetics Neuroglia - cytology Neuroglia - metabolism Neuronal Plasticity - genetics Proliferating Cell Nuclear Antigen - physiology radial glia Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - genetics teleost Teleostei Zebrafish Zebrafish Proteins - biosynthesis Zebrafish Proteins - genetics |
| title | Cxcr4 and Cxcl12 expression in radial glial cells of the brain of adult zebrafish |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T01%3A47%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cxcr4%20and%20Cxcl12%20expression%20in%20radial%20glial%20cells%20of%20the%20brain%20of%20adult%20zebrafish&rft.jtitle=Journal%20of%20comparative%20neurology%20(1911)&rft.au=Diotel,%20Nicolas&rft.date=2010-12-15&rft.volume=518&rft.issue=24&rft.spage=4855&rft.epage=4876&rft.pages=4855-4876&rft.issn=0021-9967&rft.eissn=1096-9861&rft_id=info:doi/10.1002/cne.22492&rft_dat=%3Cproquest_hal_p%3E879477094%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1766812708&rft_id=info:pmid/21031556&rfr_iscdi=true |