Bone status in a mouse model of genetic hemochromatosis

Summary Genetic hemochromatosis is a cause of osteoporosis; mechanisms leading to iron-related bone loss are not fully characterized. We assessed the bone phenotype of HFE −/− male mice, a mouse model of hemochromatosis. They had a phenotype of osteoporosis with low bone mass and alteration of the b...

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Veröffentlicht in:	Osteoporosis international 2011-08, Vol.22 (8), p.2313-2319
Hauptverfasser:	Guggenbuhl, P., Fergelot, P., Doyard, M., Libouban, H., Roth, M.-P., Gallois, Y., Chalès, G., Loréal, O., Chappard, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Biological and medical sciences Bone (trabecular) Bone histomorphometry Bone loss Bone mass Bone turnover Bones Computed tomography Data processing Disease Models, Animal Diseases of the osteoarticular system Endocrinology Endocrinology and metabolism Genetic disorders Genetics Hemochromatosis Hemochromatosis - complications Hemochromatosis - genetics Hemochromatosis - metabolism Hemochromatosis Protein Histocompatibility Antigens Class I Histocompatibility Antigens Class I - genetics Human health and pathology Hypogonadism Iron Iron - metabolism Life Sciences Liver Liver - metabolism Male Medical sciences Medicine Medicine & Public Health Membrane Proteins Membrane Proteins - genetics Metabolic diseases Metals (hemochromatosis...) Mice Mice, Inbred C57BL Mice, Knockout Original Article Orthopedics Osteoclasts Osteoclasts - pathology Osteoporosis Osteoporosis - etiology Osteoporosis - metabolism Osteoporosis - pathology Osteoporosis. Osteomalacia. Paget disease Other metabolic disorders Phenotype Rheumatology Rhumatology and musculoskeletal system Rodents Tibia Tibia - metabolism Tibia - pathology X-Ray Microtomography X-Ray Microtomography - methods
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