Non-motor dopamine withdrawal syndrome after surgery for Parkinson’s disease: predictors and underlying mesolimbic denervation

Apathy has been reported to occur after subthalamic nucleus stimulation, a treatment of motor complications in advanced Parkinson’s disease. We carried out a prospective study of the occurrence of apathy and associated symptoms, predictors and mechanisms in the year following subthalamic stimulation...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2010-04, Vol.133 (4), p.1111-1127
Hauptverfasser:	Thobois, Stéphane, Ardouin, Claire, Lhommée, Eugénie, Klinger, Hélène, Lagrange, Christelle, Xie, Jing, Fraix, Valérie, Coelho Braga, Maria Clara, Hassani, Rachid, Kistner, Andrea, Juphard, Alexandra, Seigneuret, Eric, Chabardes, Stephan, Mertens, Patrick, Polo, Gustavo, Reilhac, Anthonin, Costes, Nicolas, LeBars, Didier, Savasta, Marc, Tremblay, Léon, Quesada, Jean-Louis, Bosson, Jean-Luc, Benabid, Alim-Louis, Broussolle, Emmanuel, Pollak, Pierre, Krack, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged anxiety apathy Biological and medical sciences Deep Brain Stimulation Deep Brain Stimulation - adverse effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Denervation Denervation - psychology Depression Depression - etiology Depression - psychology dopamine Dopamine Agonists Dopamine Agonists - adverse effects Double-Blind Method Female Follow-Up Studies Humans Life Sciences Limbic System Limbic System - surgery Male Medical sciences Middle Aged Neurology Neurons and Cognition Parkinson Disease Parkinson Disease - drug therapy Parkinson Disease - psychology Parkinson Disease - surgery Parkinson’s disease Postoperative Complications Postoperative Complications - chemically induced Postoperative Complications - etiology Postoperative Complications - psychology Predictive Value of Tests Prospective Studies Substance Withdrawal Syndrome Substance Withdrawal Syndrome - etiology Substance Withdrawal Syndrome - psychology subthalamic nucleus stimulation
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