Deregulation of Aurora kinase gene expression in human testicular germ cell tumours

Summary The Aurora kinases regulate chromosome segregation and cytokinesis, and alterations in their expression associate with cell malignant transformation. In this study, we demonstrated by qRT‐PCR analysis of 14 seminomas that Aurora‐A mRNA was, with respect to control tissues, augmented in five...

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Veröffentlicht in:	Andrologia 2010-08, Vol.42 (4), p.260-267
Hauptverfasser:	Baldini, E., Arlot-Bonnemains, Y., Mottolese, M., Sentinelli, S., Antoniani, B., Sorrenti, S., Salducci, M., Comini, E., Ulisse, S., D'Armiento, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aneuploidy Aurora Kinase B Aurora Kinase C Aurora Kinases Biological and medical sciences Cancer Cellular Biology Chromosome aberrations Gene Expression Regulation, Neoplastic genomic instability Gynecology. Andrology. Obstetrics Humans Life Sciences Male Male genital diseases Medical genetics Medical sciences Middle Aged mitosis Neoplasms, Germ Cell and Embryonal - genetics Protein-Serine-Threonine Kinases - genetics RNA, Messenger Seminoma - genetics testicular germ cell tumour Testicular Neoplasms - genetics Testis - enzymology Up-Regulation
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Zusammenfassung:	Summary The Aurora kinases regulate chromosome segregation and cytokinesis, and alterations in their expression associate with cell malignant transformation. In this study, we demonstrated by qRT‐PCR analysis of 14 seminomas that Aurora‐A mRNA was, with respect to control tissues, augmented in five of 14 tumour tissues by 2.17 ± 0.30 fold (P
ISSN:	0303-4569 1439-0272
DOI:	10.1111/j.1439-0272.2009.00987.x