The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1

The NMDA subtype of glutamate receptors (NMDAR) at excitatory neuronal synapses plays a key role in synaptic plasticity. The extracellular signal-regulated kinase (ERK1,2 or ERK) pathway is an essential component of NMDAR signal transduction controlling the neuroplasticity underlying memory processe...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2003-11, Vol.40 (4), p.775-784
Hauptverfasser:	Krapivinsky, Grigory, Krapivinsky, Luba, Manasian, Yunona, Ivanov, Anton, Tyzio, Roman, Pellegrino, Christophe, Ben-Ari, Yehezkel, Clapham, David E, Medina, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Animals, Newborn Binding Sites Binding Sites - genetics Calcium Signaling Calcium Signaling - drug effects Calcium Signaling - physiology Cells, Cultured Cellular Biology extracellular signal-regulated kinase Fetus Hippocampus Hippocampus - metabolism Humans Kinases Life Sciences Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases - metabolism Mutation Mutation - genetics N-Methylaspartate N-Methylaspartate - pharmacology Neuronal Plasticity Neuronal Plasticity - genetics Neurons Organ Culture Techniques Peptides Peptides - pharmacology Protein Structure, Tertiary Protein Structure, Tertiary - genetics Proteins ras-GRF1 ras-GRF1 - antagonists & inhibitors ras-GRF1 - genetics ras-GRF1 - metabolism Rats Receptors, N-Methyl-D-Aspartate Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction Signal Transduction - genetics Software Synapses Synapses - enzymology Synaptic Transmission Synaptic Transmission - genetics
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