Hypoxic Single-Pass Isolated Hepatic Perfusion of Hypotonic Cisplatin: Safety Study in the Pig

Background Isolated hepatic perfusion (IHP) of chemotherapy has been proposed to deliver high doses of drug while avoiding systemic toxicity. Hypotonic cisplatin has a high in vitro activity on human colon cancer cells. We studied the safety of a 30-min hypoxic single-pass IHP with hypotonic cisplat...

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Veröffentlicht in:	Annals of surgical oncology 2010-03, Vol.17 (3), p.898-906
Hauptverfasser:	Ortega-Deballon, Pablo, Facy, Olivier, Consolo, David, Magnin, Guy, Tixier, Hervé, Simonet, Michel, Rat, Patrick, Chauffert, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Chemotherapy, Cancer, Regional Perfusion Cisplatin - administration & dosage Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colonic Neoplasms - surgery Dose-Response Relationship, Drug Female Human health and pathology Humans Hypotonic Solutions Life Sciences Liver - blood supply Liver - drug effects Liver - surgery Medicine Medicine & Public Health Oncology Surgery Surgical Oncology Sus scrofa Tissue Distribution Translational Research and Biomarkers Tumor Cells, Cultured
Online-Zugang:	Volltext
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