EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration
The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressiv...
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| Veröffentlicht in: | The European respiratory journal 2009-12, Vol.34 (6), p.1477-1486 |
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| creator | Field, J. K Liloglou, T Niaz, A Bryan, J Gosney, J. R Giles, T Brambilla, C Brambilla, E Vesin, A Timsit, J-F Hainaut, P Martinet, Y Vignaud, J. M Thunnissen, F. B Prinsen, C Snijders, P. J Smit, E. F Sozzi, G Roz, L Risch, A Becker, H. D Elborn, J. S Magee, N. D Montuenga, L. M Pajares, M. J Lozano, M. D O'Byrne, K. J Harrison, D. J Niklinski, J Cassidy, A EUELC Collaborators |
| description | The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARbeta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes. |
| doi_str_mv | 10.1183/09031936.00077809 |
| format | Article |
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J ; Niklinski, J ; Cassidy, A ; EUELC Collaborators ; EUELC Collaborators ; the EUELC Collaborators</creatorcontrib><description>The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARbeta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00077809</identifier><identifier>PMID: 19948914</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - metabolism ; DNA Methylation ; DNA Mutational Analysis ; Epithelium - metabolism ; Europe ; Female ; Humans ; Immunohistochemistry - methods ; Life Sciences ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Male ; Medical sciences ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; Pneumology ; Receptors, Retinoic Acid - metabolism ; Santé publique et épidémiologie ; Telomerase - metabolism ; Tumors of the respiratory system and mediastinum</subject><ispartof>The European respiratory journal, 2009-12, Vol.34 (6), p.1477-1486</ispartof><rights>2015 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-bc435a2da7a23340ae018344f76b9ae3ad2bc76da0288e39a5edf3027cca86093</citedby><cites>FETCH-LOGICAL-c441t-bc435a2da7a23340ae018344f76b9ae3ad2bc76da0288e39a5edf3027cca86093</cites><orcidid>0000-0002-6063-7383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22162335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19948914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00453198$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Field, J. K</creatorcontrib><creatorcontrib>Liloglou, T</creatorcontrib><creatorcontrib>Niaz, A</creatorcontrib><creatorcontrib>Bryan, J</creatorcontrib><creatorcontrib>Gosney, J. R</creatorcontrib><creatorcontrib>Giles, T</creatorcontrib><creatorcontrib>Brambilla, C</creatorcontrib><creatorcontrib>Brambilla, E</creatorcontrib><creatorcontrib>Vesin, A</creatorcontrib><creatorcontrib>Timsit, J-F</creatorcontrib><creatorcontrib>Hainaut, P</creatorcontrib><creatorcontrib>Martinet, Y</creatorcontrib><creatorcontrib>Vignaud, J. M</creatorcontrib><creatorcontrib>Thunnissen, F. B</creatorcontrib><creatorcontrib>Prinsen, C</creatorcontrib><creatorcontrib>Snijders, P. J</creatorcontrib><creatorcontrib>Smit, E. F</creatorcontrib><creatorcontrib>Sozzi, G</creatorcontrib><creatorcontrib>Roz, L</creatorcontrib><creatorcontrib>Risch, A</creatorcontrib><creatorcontrib>Becker, H. D</creatorcontrib><creatorcontrib>Elborn, J. S</creatorcontrib><creatorcontrib>Magee, N. D</creatorcontrib><creatorcontrib>Montuenga, L. M</creatorcontrib><creatorcontrib>Pajares, M. J</creatorcontrib><creatorcontrib>Lozano, M. D</creatorcontrib><creatorcontrib>O'Byrne, K. J</creatorcontrib><creatorcontrib>Harrison, D. J</creatorcontrib><creatorcontrib>Niklinski, J</creatorcontrib><creatorcontrib>Cassidy, A</creatorcontrib><creatorcontrib>EUELC Collaborators</creatorcontrib><creatorcontrib>EUELC Collaborators</creatorcontrib><creatorcontrib>the EUELC Collaborators</creatorcontrib><title>EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular-pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARbeta genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>DNA Methylation</subject><subject>DNA Mutational Analysis</subject><subject>Epithelium - metabolism</subject><subject>Europe</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Life Sciences</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Pneumology</subject><subject>Receptors, Retinoic Acid - metabolism</subject><subject>Santé publique et épidémiologie</subject><subject>Telomerase - metabolism</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUGP0zAQhS0EYsvCD-CCfIFTs4xjN4m5raLCIkVwgD1bE8dJXZw4stNd9R_ws3HV7nIaWfO9p_F7hLxncMNYxT-DBM4kL24AoCwrkC_IinEpMw7AX5LVaZ-dgCvyJsY9ACsEZ6_JFZNSVJKJFfm7vd82NZ2D3xu9fKFIx4NbbKbNtASzPr_mQ5h9NDQuh-5IF0_t9GDiYgdcDDUY3DGtcDD0x6-6qdcUp-5EJQRbZ-MuubbWtzj9ob0P1E-Dt9NAtXcOWx9wsX56S1716KJ5d5nX5P7r9nd9lzU_v32vb5tMC8GWrNWCbzDvsMSccwFoICUhRF8WrUTDsctbXRYdQl5VhkvcmK7nkJdaY1WA5NdkffbdoVNzsCOGo_Jo1d1to-wUTRgVgNikYKsHlnB2xnXwMQbTP2sYqFMJ6qkE9VRC0nw4a-ZDO5ruv-KSegI-XgCMGl0fcNI2PnN5zor0uU3iPl1utcPu0Qaj4ojOJVumTNhzoQrFRFnyf0c2nMc</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Field, J. 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| ispartof | The European respiratory journal, 2009-12, Vol.34 (6), p.1477-1486 |
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| subjects | Aged Biological and medical sciences Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - metabolism DNA Methylation DNA Mutational Analysis Epithelium - metabolism Europe Female Humans Immunohistochemistry - methods Life Sciences Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Male Medical sciences Middle Aged Oligonucleotide Array Sequence Analysis Pneumology Receptors, Retinoic Acid - metabolism Santé publique et épidémiologie Telomerase - metabolism Tumors of the respiratory system and mediastinum |
| title | EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration |
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