Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients
A high prevalence (52%) of hyperhomocysteinemia is observed in Crohn disease (CD), however it is not well documented in ulcerative colitis (UC). Furthermore, in the different works studying hyperhomocysteinemia the associated factors are different. Prospective evaluation of hyperhomocysteinemia in i...
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| Veröffentlicht in: | La revue de medecine interne 2006-02, Vol.27 (2), p.106-110 |
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| creator | Roblin, X Germain, E Phelip, J M Ducros, V Pofelski, J Heluwaert, F Oltean, P Faucheron, J L Bonaz, B |
| description | A high prevalence (52%) of hyperhomocysteinemia is observed in Crohn disease (CD), however it is not well documented in ulcerative colitis (UC). Furthermore, in the different works studying hyperhomocysteinemia the associated factors are different.
Prospective evaluation of hyperhomocysteinemia in inflammatory bowel disease (IBD) patients, of the risk factors and the determination of a potential risk of colorectal carcinoma in case of hyperhomocysteinemia.
IBD patients followed in our department were prospectively recruited between November 2003-September 2004. To be included patients should have passed a coloscopy in the two years. Patients with kidney failure or drugs supposed, to interfere with homocystéine metabolism (folates, vitamin B12, methotrexate) were excluded from the study. The following parameters were analysed: age, sex, clinical activity indexes (CDAI for Crohn disease and CAI for ulcerative colitis), length-extent and type of the disease (CD or UC), smoking, plasma homocystein concentration, folates and vitamin B12.
Eighty-one patients (60 CD, 21 UC, mean age 43.8 +/- 17.3) were included, 30 had an active disease at inclusion and 16 were smokers. The prevalence of high homocystein concentration was 55.6%. In univariate analysis a low rate of folates was the only risk factor for a high homocystein concentration (74 vs. 52.8%; P = 0.018). Smoking was almost an associated factor. In multivariate analysis, a low rate of folate was the only risk factor of hyperhomocysteinemia, OR = 3.59 [1.27-10.17]. Five endoscopic lesions considered as precancerous were described; these patients had all a hyperhomocysteinemia.
The prevalence of hyperhomocysteinemia is high in UC and in CD. A low folate rate is the only risk factor observed in our study. There is a possible link between colorectal cancer and hyperhomocysteinemia. A high Plasma homocystein concentration must be search in inflammatory bowel disease patients and a substitutive treatment of folates and vitamin B12 is necessary in case of hyperhomocysteinemia. |
| doi_str_mv | 10.1016/j.revmed.2005.11.005 |
| format | Article |
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Prospective evaluation of hyperhomocysteinemia in inflammatory bowel disease (IBD) patients, of the risk factors and the determination of a potential risk of colorectal carcinoma in case of hyperhomocysteinemia.
IBD patients followed in our department were prospectively recruited between November 2003-September 2004. To be included patients should have passed a coloscopy in the two years. Patients with kidney failure or drugs supposed, to interfere with homocystéine metabolism (folates, vitamin B12, methotrexate) were excluded from the study. The following parameters were analysed: age, sex, clinical activity indexes (CDAI for Crohn disease and CAI for ulcerative colitis), length-extent and type of the disease (CD or UC), smoking, plasma homocystein concentration, folates and vitamin B12.
Eighty-one patients (60 CD, 21 UC, mean age 43.8 +/- 17.3) were included, 30 had an active disease at inclusion and 16 were smokers. The prevalence of high homocystein concentration was 55.6%. In univariate analysis a low rate of folates was the only risk factor for a high homocystein concentration (74 vs. 52.8%; P = 0.018). Smoking was almost an associated factor. In multivariate analysis, a low rate of folate was the only risk factor of hyperhomocysteinemia, OR = 3.59 [1.27-10.17]. Five endoscopic lesions considered as precancerous were described; these patients had all a hyperhomocysteinemia.
The prevalence of hyperhomocysteinemia is high in UC and in CD. A low folate rate is the only risk factor observed in our study. There is a possible link between colorectal cancer and hyperhomocysteinemia. A high Plasma homocystein concentration must be search in inflammatory bowel disease patients and a substitutive treatment of folates and vitamin B12 is necessary in case of hyperhomocysteinemia.</description><identifier>ISSN: 0248-8663</identifier><identifier>EISSN: 1768-3122</identifier><identifier>DOI: 10.1016/j.revmed.2005.11.005</identifier><identifier>PMID: 16376461</identifier><language>fre</language><publisher>France: Elsevier</publisher><subject>Adult ; Female ; Folic Acid Deficiency ; Folic Acid Deficiency - complications ; Human health and pathology ; Humans ; Hyperhomocysteinemia ; Hyperhomocysteinemia - epidemiology ; Hyperhomocysteinemia - etiology ; Hépatology and Gastroenterology ; Inflammatory Bowel Diseases ; Inflammatory Bowel Diseases - complications ; Life Sciences ; Male ; Middle Aged ; Odds Ratio ; Prevalence ; Prospective Studies ; Risk Factors</subject><ispartof>La revue de medecine interne, 2006-02, Vol.27 (2), p.106-110</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-4232-6039 ; 0000-0002-7929-4878 ; 0000-0003-1858-8941 ; 0000-0002-2840-0108</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16376461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00410548$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Roblin, X</creatorcontrib><creatorcontrib>Germain, E</creatorcontrib><creatorcontrib>Phelip, J M</creatorcontrib><creatorcontrib>Ducros, V</creatorcontrib><creatorcontrib>Pofelski, J</creatorcontrib><creatorcontrib>Heluwaert, F</creatorcontrib><creatorcontrib>Oltean, P</creatorcontrib><creatorcontrib>Faucheron, J L</creatorcontrib><creatorcontrib>Bonaz, B</creatorcontrib><title>Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients</title><title>La revue de medecine interne</title><addtitle>Rev Med Interne</addtitle><description>A high prevalence (52%) of hyperhomocysteinemia is observed in Crohn disease (CD), however it is not well documented in ulcerative colitis (UC). Furthermore, in the different works studying hyperhomocysteinemia the associated factors are different.
Prospective evaluation of hyperhomocysteinemia in inflammatory bowel disease (IBD) patients, of the risk factors and the determination of a potential risk of colorectal carcinoma in case of hyperhomocysteinemia.
IBD patients followed in our department were prospectively recruited between November 2003-September 2004. To be included patients should have passed a coloscopy in the two years. Patients with kidney failure or drugs supposed, to interfere with homocystéine metabolism (folates, vitamin B12, methotrexate) were excluded from the study. The following parameters were analysed: age, sex, clinical activity indexes (CDAI for Crohn disease and CAI for ulcerative colitis), length-extent and type of the disease (CD or UC), smoking, plasma homocystein concentration, folates and vitamin B12.
Eighty-one patients (60 CD, 21 UC, mean age 43.8 +/- 17.3) were included, 30 had an active disease at inclusion and 16 were smokers. The prevalence of high homocystein concentration was 55.6%. In univariate analysis a low rate of folates was the only risk factor for a high homocystein concentration (74 vs. 52.8%; P = 0.018). Smoking was almost an associated factor. In multivariate analysis, a low rate of folate was the only risk factor of hyperhomocysteinemia, OR = 3.59 [1.27-10.17]. Five endoscopic lesions considered as precancerous were described; these patients had all a hyperhomocysteinemia.
The prevalence of hyperhomocysteinemia is high in UC and in CD. A low folate rate is the only risk factor observed in our study. There is a possible link between colorectal cancer and hyperhomocysteinemia. A high Plasma homocystein concentration must be search in inflammatory bowel disease patients and a substitutive treatment of folates and vitamin B12 is necessary in case of hyperhomocysteinemia.</description><subject>Adult</subject><subject>Female</subject><subject>Folic Acid Deficiency</subject><subject>Folic Acid Deficiency - complications</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hyperhomocysteinemia</subject><subject>Hyperhomocysteinemia - epidemiology</subject><subject>Hyperhomocysteinemia - etiology</subject><subject>Hépatology and Gastroenterology</subject><subject>Inflammatory Bowel Diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0248-8663</issn><issn>1768-3122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMoOj7-gUhWrmzNTdq0dSeDLxhwM_tym97SSF82mZH-eyOjwoGz-c7hcBi7BhGDAH3_Ec-076mOpRBpDBAHO2IryHQeKZDymK2ETPIo11qdsXPnPoQQIVmcsjPQKtOJhhXrntH4cXYcnRuNRU81_7K-5e0y0dyO_WgW58kO1FvkdghqOux7DKGFV-MXdby2jtDRA5_m0U1kvN0Td35XLz-BHPiE3tLg3SU7abBzdPXrF2z7_LRdv0ab95e39eMmasN6H4E0qZRJBlonaVNglsqqTiiHNK-EQtFUIJDIQEFGysxksgJdqEphQXXSqAt2d6htsSun2fY4L-WItnx93JR2cDT3pRAJiDTJ9xDw2wMe5n_uyPmyt85Q1-FA486VOtNKFSACePML7qpw_H_135vqG2TBekg</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Roblin, X</creator><creator>Germain, E</creator><creator>Phelip, J M</creator><creator>Ducros, V</creator><creator>Pofelski, J</creator><creator>Heluwaert, F</creator><creator>Oltean, P</creator><creator>Faucheron, J L</creator><creator>Bonaz, B</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-4232-6039</orcidid><orcidid>https://orcid.org/0000-0002-7929-4878</orcidid><orcidid>https://orcid.org/0000-0003-1858-8941</orcidid><orcidid>https://orcid.org/0000-0002-2840-0108</orcidid></search><sort><creationdate>200602</creationdate><title>Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients</title><author>Roblin, X ; Germain, E ; Phelip, J M ; Ducros, V ; Pofelski, J ; Heluwaert, F ; Oltean, P ; Faucheron, J L ; Bonaz, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h176t-12c5224716645f9a752bd4e8158b03a0fb10aeec19ec227c72b1693b3a9ed4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Female</topic><topic>Folic Acid Deficiency</topic><topic>Folic Acid Deficiency - complications</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Hyperhomocysteinemia</topic><topic>Hyperhomocysteinemia - epidemiology</topic><topic>Hyperhomocysteinemia - etiology</topic><topic>Hépatology and Gastroenterology</topic><topic>Inflammatory Bowel Diseases</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roblin, X</creatorcontrib><creatorcontrib>Germain, E</creatorcontrib><creatorcontrib>Phelip, J M</creatorcontrib><creatorcontrib>Ducros, V</creatorcontrib><creatorcontrib>Pofelski, J</creatorcontrib><creatorcontrib>Heluwaert, F</creatorcontrib><creatorcontrib>Oltean, P</creatorcontrib><creatorcontrib>Faucheron, J L</creatorcontrib><creatorcontrib>Bonaz, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>La revue de medecine interne</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roblin, X</au><au>Germain, E</au><au>Phelip, J M</au><au>Ducros, V</au><au>Pofelski, J</au><au>Heluwaert, F</au><au>Oltean, P</au><au>Faucheron, J L</au><au>Bonaz, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients</atitle><jtitle>La revue de medecine interne</jtitle><addtitle>Rev Med Interne</addtitle><date>2006-02</date><risdate>2006</risdate><volume>27</volume><issue>2</issue><spage>106</spage><epage>110</epage><pages>106-110</pages><issn>0248-8663</issn><eissn>1768-3122</eissn><abstract>A high prevalence (52%) of hyperhomocysteinemia is observed in Crohn disease (CD), however it is not well documented in ulcerative colitis (UC). Furthermore, in the different works studying hyperhomocysteinemia the associated factors are different.
Prospective evaluation of hyperhomocysteinemia in inflammatory bowel disease (IBD) patients, of the risk factors and the determination of a potential risk of colorectal carcinoma in case of hyperhomocysteinemia.
IBD patients followed in our department were prospectively recruited between November 2003-September 2004. To be included patients should have passed a coloscopy in the two years. Patients with kidney failure or drugs supposed, to interfere with homocystéine metabolism (folates, vitamin B12, methotrexate) were excluded from the study. The following parameters were analysed: age, sex, clinical activity indexes (CDAI for Crohn disease and CAI for ulcerative colitis), length-extent and type of the disease (CD or UC), smoking, plasma homocystein concentration, folates and vitamin B12.
Eighty-one patients (60 CD, 21 UC, mean age 43.8 +/- 17.3) were included, 30 had an active disease at inclusion and 16 were smokers. The prevalence of high homocystein concentration was 55.6%. In univariate analysis a low rate of folates was the only risk factor for a high homocystein concentration (74 vs. 52.8%; P = 0.018). Smoking was almost an associated factor. In multivariate analysis, a low rate of folate was the only risk factor of hyperhomocysteinemia, OR = 3.59 [1.27-10.17]. Five endoscopic lesions considered as precancerous were described; these patients had all a hyperhomocysteinemia.
The prevalence of hyperhomocysteinemia is high in UC and in CD. A low folate rate is the only risk factor observed in our study. There is a possible link between colorectal cancer and hyperhomocysteinemia. A high Plasma homocystein concentration must be search in inflammatory bowel disease patients and a substitutive treatment of folates and vitamin B12 is necessary in case of hyperhomocysteinemia.</abstract><cop>France</cop><pub>Elsevier</pub><pmid>16376461</pmid><doi>10.1016/j.revmed.2005.11.005</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4232-6039</orcidid><orcidid>https://orcid.org/0000-0002-7929-4878</orcidid><orcidid>https://orcid.org/0000-0003-1858-8941</orcidid><orcidid>https://orcid.org/0000-0002-2840-0108</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | La revue de medecine interne, 2006-02, Vol.27 (2), p.106-110 |
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| subjects | Adult Female Folic Acid Deficiency Folic Acid Deficiency - complications Human health and pathology Humans Hyperhomocysteinemia Hyperhomocysteinemia - epidemiology Hyperhomocysteinemia - etiology Hépatology and Gastroenterology Inflammatory Bowel Diseases Inflammatory Bowel Diseases - complications Life Sciences Male Middle Aged Odds Ratio Prevalence Prospective Studies Risk Factors |
| title | Factors associated with hyperhomocysteinemia in inflammatory bowel disease: prospective study in 81 patients |
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