Control of cellular respiration in vivo by mitochondrial outer membrane and by Creatine Kinase. A new speculative hypothesis: possible involvement of mitochondrial-cytoskeleton interactions

The current problems of regulation of myocardial energy metabolism and oxidative phosphorylation in vivo are considered. With this purpose, retarded diffusion of ADP in cardiomyocytes was studied by analysis of elevated apparent K m for this substrate in regulation of respiration of saponin-skinned...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1995, Vol.27 (1), p.625-645
Hauptverfasser:	Saks, Valdur A., Kuznetsov, Andrei V., Khuchua, Zaza A., Vasilyeva, Elena V., Belikova, Julia O., Kesvatera, Tõnu, Tiivel, Toomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Adenosine Diphosphate - metabolism Adenosine Diphosphate - pharmacology ADP Animals Biochemistry, Molecular Biology Cells, Cultured Compartmentation Creatine Kinase Creatine Kinase - metabolism Cytochrome c Group Cytochrome c Group - pharmacology Cytoskeleton Cytoskeleton - metabolism Diffusion Homeostasis Intracellular Membranes Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Kinetics Life Sciences Male Mice Mitochondria, Heart Mitochondria, Heart - metabolism Mitochondria, Heart - ultrastructure Mitochondrial outer membrane Models, Cardiovascular Muscle cells Muscle Fibers, Skeletal Muscle Fibers, Skeletal - physiology Muscle Fibers, Skeletal - ultrastructure Muscle, Skeletal Muscle, Skeletal - metabolism Myocardium Myocardium - metabolism Oxidative phosphorylation Oxygen Consumption Oxygen Consumption - drug effects Potassium Chloride Potassium Chloride - pharmacology Rats Rats, Wistar Regulaton
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