Classification of Nerve Cells from Substantia Nigra of Patients with Parkinson's Disease and Amyotrophic Lateral Sclerosis with the Use of X-ray Fluorescence Microscopy and Multivariate Methods
The causes of Parkinson's disease and amyotrophic lateral sclerosis are still not known, but there is evidence that metal ions can be involved in processes leading to degeneration and atrophy of neurons in the case of these two neurodegenerative disorders. A synchrotron microbeam X-ray fluoresc...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2005-05, Vol.77 (9), p.2895-2900 |
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| creator | Chwiej, Joanna Fik-Mazgaj, Katarzyna Szczerbowska-Boruchowska, Magdalena Lankosz, Marek Ostachowicz, Jerzy Adamek, Dariusz Simionovici, Alexandre Bohic, Sylvain |
| description | The causes of Parkinson's disease and amyotrophic lateral sclerosis are still not known, but there is evidence that metal ions can be involved in processes leading to degeneration and atrophy of neurons in the case of these two neurodegenerative disorders. A synchrotron microbeam X-ray fluorescence technique was applied for topographic and quantitative analyses of selected elements on central nervous system tissue. The thin slices of brain were measured on the undulator beamline ID 22 at the European Synchrotron Radiation Facility in Grenoble, France. The polychromatic beam with the dimension of 5 μm × 2 μm (horizontal × vertical) was used in measurements. Tissues of substantia nigra representing Parkinson's disease, amyotrophic lateral sclerosis, and the control case were scanned. The results obtained indicated that accumulation of some elements depends on the case that the substantia nigra represents. Some variability in the elemental distribution for a given case was noticed as well. To investigate if present differences in the elemental accumulation between analyzed cases are statistically significant, multivariate methods were used. Cluster and discriminant analyses confirmed the significance of the differences in elemental accumulation in biological structures representing the examined cases. The methods used let us classify these structures in separate groups and determine elements, which play the greatest role in the differentiation of the biological structures for each case. |
| doi_str_mv | 10.1021/ac048173k |
| format | Article |
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A synchrotron microbeam X-ray fluorescence technique was applied for topographic and quantitative analyses of selected elements on central nervous system tissue. The thin slices of brain were measured on the undulator beamline ID 22 at the European Synchrotron Radiation Facility in Grenoble, France. The polychromatic beam with the dimension of 5 μm × 2 μm (horizontal × vertical) was used in measurements. Tissues of substantia nigra representing Parkinson's disease, amyotrophic lateral sclerosis, and the control case were scanned. The results obtained indicated that accumulation of some elements depends on the case that the substantia nigra represents. Some variability in the elemental distribution for a given case was noticed as well. To investigate if present differences in the elemental accumulation between analyzed cases are statistically significant, multivariate methods were used. Cluster and discriminant analyses confirmed the significance of the differences in elemental accumulation in biological structures representing the examined cases. The methods used let us classify these structures in separate groups and determine elements, which play the greatest role in the differentiation of the biological structures for each case.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/ac048173k</identifier><identifier>PMID: 15859608</identifier><identifier>CODEN: ANCHAM</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Amyotrophic Lateral Sclerosis ; Amyotrophic Lateral Sclerosis - pathology ; Analytical chemistry ; Biological and medical sciences ; Brain ; Chemistry ; Cluster Analysis ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Discriminant Analysis ; Exact sciences and technology ; Humans ; Measurement techniques ; Medical sciences ; Metals ; Metals - analysis ; Microscopy, Fluorescence ; Microscopy, Fluorescence - methods ; Neurological disorders ; Neurology ; Neurons ; Neurons - chemistry ; Neurons - classification ; Parkinson Disease ; Parkinson Disease - pathology ; Spectrometric and optical methods ; Substantia Nigra ; Substantia Nigra - chemistry ; Substantia Nigra - pathology ; Tissues</subject><ispartof>Analytical chemistry (Washington), 2005-05, Vol.77 (9), p.2895-2900</ispartof><rights>Copyright © 2005 American Chemical Society</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American Chemical Society May 1, 2005</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a476t-1960b4bab37ed6888d09ff5c4b6e784bc826b9c50c85445e0a4a1eb0b8cbad5b3</citedby><cites>FETCH-LOGICAL-a476t-1960b4bab37ed6888d09ff5c4b6e784bc826b9c50c85445e0a4a1eb0b8cbad5b3</cites><orcidid>0000-0001-6355-7592 ; 0000-0001-5349-6482</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ac048173k$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ac048173k$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,776,780,881,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16758746$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15859608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00388934$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chwiej, Joanna</creatorcontrib><creatorcontrib>Fik-Mazgaj, Katarzyna</creatorcontrib><creatorcontrib>Szczerbowska-Boruchowska, Magdalena</creatorcontrib><creatorcontrib>Lankosz, Marek</creatorcontrib><creatorcontrib>Ostachowicz, Jerzy</creatorcontrib><creatorcontrib>Adamek, Dariusz</creatorcontrib><creatorcontrib>Simionovici, Alexandre</creatorcontrib><creatorcontrib>Bohic, Sylvain</creatorcontrib><title>Classification of Nerve Cells from Substantia Nigra of Patients with Parkinson's Disease and Amyotrophic Lateral Sclerosis with the Use of X-ray Fluorescence Microscopy and Multivariate Methods</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>The causes of Parkinson's disease and amyotrophic lateral sclerosis are still not known, but there is evidence that metal ions can be involved in processes leading to degeneration and atrophy of neurons in the case of these two neurodegenerative disorders. A synchrotron microbeam X-ray fluorescence technique was applied for topographic and quantitative analyses of selected elements on central nervous system tissue. The thin slices of brain were measured on the undulator beamline ID 22 at the European Synchrotron Radiation Facility in Grenoble, France. The polychromatic beam with the dimension of 5 μm × 2 μm (horizontal × vertical) was used in measurements. Tissues of substantia nigra representing Parkinson's disease, amyotrophic lateral sclerosis, and the control case were scanned. The results obtained indicated that accumulation of some elements depends on the case that the substantia nigra represents. Some variability in the elemental distribution for a given case was noticed as well. To investigate if present differences in the elemental accumulation between analyzed cases are statistically significant, multivariate methods were used. Cluster and discriminant analyses confirmed the significance of the differences in elemental accumulation in biological structures representing the examined cases. The methods used let us classify these structures in separate groups and determine elements, which play the greatest role in the differentiation of the biological structures for each case.</description><subject>Amyotrophic Lateral Sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Analytical chemistry</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Chemistry</subject><subject>Cluster Analysis</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Discriminant Analysis</subject><subject>Exact sciences and technology</subject><subject>Humans</subject><subject>Measurement techniques</subject><subject>Medical sciences</subject><subject>Metals</subject><subject>Metals - analysis</subject><subject>Microscopy, Fluorescence</subject><subject>Microscopy, Fluorescence - methods</subject><subject>Neurological disorders</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurons - chemistry</subject><subject>Neurons - classification</subject><subject>Parkinson Disease</subject><subject>Parkinson Disease - pathology</subject><subject>Spectrometric and optical methods</subject><subject>Substantia Nigra</subject><subject>Substantia Nigra - chemistry</subject><subject>Substantia Nigra - pathology</subject><subject>Tissues</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0tFu0zAUBuAIgVgZXPACyEIaCImAnTixe1kC2xDdmNRN2p117DrUmxMX2yn08XgzXFq1ElxwFUX58sv_8cmy5wS_I7gg70Fhygkr7x9kI1IVOK85Lx5mI4xxmRcM46PsSQh3GBOCSf04OyIVr8Y15qPsV2MhBNMaBdG4HrkWXWq_0qjR1gbUeteh2SBDhD4aQJfmm4cNukpc9zGgHyYu0pu_N31w_euAPpqgIWgE_RxNurWL3i0XRqEpRO3Bopmy2rtgdr_GhUY3iafM29zDGp3awXkdlO6VRhdGJavccv0n72Kw0azAm5SFLnRcuHl4mj1qwQb9bPc8zm5OP1035_n069nnZjLNgbI65iT1lVSCLJmep_nwOR63baWorDXjVCpe1HKsKqx4RWmlMVAgWmLJlYR5Jcvj7O02dwFWLL3pwK-FAyPOJ1ORymvfiTRvzsclXZHEX2350rvvgw5RdCaVshZ67YYgasbGBeb8vzDda8VZgRN8-Re8c4PvU2dREMZrVlKa0Jst2swteN3uj0qw2CyL2C9Lsi92gYPs9Pwgd9uRwMkOQFBgWw-9MuHgapZORuvk8q0zIeqf--9pKVLNklXi-mommi9N0eCzD-L2kAsqHEr8e8DfrT3kew</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Chwiej, Joanna</creator><creator>Fik-Mazgaj, Katarzyna</creator><creator>Szczerbowska-Boruchowska, Magdalena</creator><creator>Lankosz, Marek</creator><creator>Ostachowicz, Jerzy</creator><creator>Adamek, Dariusz</creator><creator>Simionovici, Alexandre</creator><creator>Bohic, Sylvain</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6355-7592</orcidid><orcidid>https://orcid.org/0000-0001-5349-6482</orcidid></search><sort><creationdate>20050501</creationdate><title>Classification of Nerve Cells from Substantia Nigra of Patients with Parkinson's Disease and Amyotrophic Lateral Sclerosis with the Use of X-ray Fluorescence Microscopy and Multivariate Methods</title><author>Chwiej, Joanna ; Fik-Mazgaj, Katarzyna ; Szczerbowska-Boruchowska, Magdalena ; Lankosz, Marek ; Ostachowicz, Jerzy ; Adamek, Dariusz ; Simionovici, Alexandre ; Bohic, Sylvain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a476t-1960b4bab37ed6888d09ff5c4b6e784bc826b9c50c85445e0a4a1eb0b8cbad5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amyotrophic Lateral Sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Analytical chemistry</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Chemistry</topic><topic>Cluster Analysis</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Discriminant Analysis</topic><topic>Exact sciences and technology</topic><topic>Humans</topic><topic>Measurement techniques</topic><topic>Medical sciences</topic><topic>Metals</topic><topic>Metals - analysis</topic><topic>Microscopy, Fluorescence</topic><topic>Microscopy, Fluorescence - methods</topic><topic>Neurological disorders</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurons - chemistry</topic><topic>Neurons - classification</topic><topic>Parkinson Disease</topic><topic>Parkinson Disease - pathology</topic><topic>Spectrometric and optical methods</topic><topic>Substantia Nigra</topic><topic>Substantia Nigra - chemistry</topic><topic>Substantia Nigra - pathology</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chwiej, Joanna</creatorcontrib><creatorcontrib>Fik-Mazgaj, Katarzyna</creatorcontrib><creatorcontrib>Szczerbowska-Boruchowska, Magdalena</creatorcontrib><creatorcontrib>Lankosz, Marek</creatorcontrib><creatorcontrib>Ostachowicz, Jerzy</creatorcontrib><creatorcontrib>Adamek, Dariusz</creatorcontrib><creatorcontrib>Simionovici, Alexandre</creatorcontrib><creatorcontrib>Bohic, Sylvain</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chwiej, Joanna</au><au>Fik-Mazgaj, Katarzyna</au><au>Szczerbowska-Boruchowska, Magdalena</au><au>Lankosz, Marek</au><au>Ostachowicz, Jerzy</au><au>Adamek, Dariusz</au><au>Simionovici, Alexandre</au><au>Bohic, Sylvain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Classification of Nerve Cells from Substantia Nigra of Patients with Parkinson's Disease and Amyotrophic Lateral Sclerosis with the Use of X-ray Fluorescence Microscopy and Multivariate Methods</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>77</volume><issue>9</issue><spage>2895</spage><epage>2900</epage><pages>2895-2900</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><coden>ANCHAM</coden><abstract>The causes of Parkinson's disease and amyotrophic lateral sclerosis are still not known, but there is evidence that metal ions can be involved in processes leading to degeneration and atrophy of neurons in the case of these two neurodegenerative disorders. A synchrotron microbeam X-ray fluorescence technique was applied for topographic and quantitative analyses of selected elements on central nervous system tissue. The thin slices of brain were measured on the undulator beamline ID 22 at the European Synchrotron Radiation Facility in Grenoble, France. The polychromatic beam with the dimension of 5 μm × 2 μm (horizontal × vertical) was used in measurements. Tissues of substantia nigra representing Parkinson's disease, amyotrophic lateral sclerosis, and the control case were scanned. The results obtained indicated that accumulation of some elements depends on the case that the substantia nigra represents. Some variability in the elemental distribution for a given case was noticed as well. To investigate if present differences in the elemental accumulation between analyzed cases are statistically significant, multivariate methods were used. Cluster and discriminant analyses confirmed the significance of the differences in elemental accumulation in biological structures representing the examined cases. The methods used let us classify these structures in separate groups and determine elements, which play the greatest role in the differentiation of the biological structures for each case.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>15859608</pmid><doi>10.1021/ac048173k</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6355-7592</orcidid><orcidid>https://orcid.org/0000-0001-5349-6482</orcidid></addata></record> |
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| subjects | Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis - pathology Analytical chemistry Biological and medical sciences Brain Chemistry Cluster Analysis Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Discriminant Analysis Exact sciences and technology Humans Measurement techniques Medical sciences Metals Metals - analysis Microscopy, Fluorescence Microscopy, Fluorescence - methods Neurological disorders Neurology Neurons Neurons - chemistry Neurons - classification Parkinson Disease Parkinson Disease - pathology Spectrometric and optical methods Substantia Nigra Substantia Nigra - chemistry Substantia Nigra - pathology Tissues |
| title | Classification of Nerve Cells from Substantia Nigra of Patients with Parkinson's Disease and Amyotrophic Lateral Sclerosis with the Use of X-ray Fluorescence Microscopy and Multivariate Methods |
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