Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

Bacterial products (such as endotoxins and flagellin) trigger innate immune responses through TLRs. Flagellin-induced signalling involves TLR5 and MyD88 and, according to some reports, TLR4. Whereas epithelial and dendritic cells are stimulated by flagellin in vitro, the cell contribution to the in...

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Veröffentlicht in:	European journal of immunology 2009-06, Vol.39 (6), p.1587-1596
Hauptverfasser:	Janot, Laure, Sirard, Jean-Claude, Secher, Thomas, Noulin, Nicolas, Fick, Lizette, Akira, Shizuo, Uematsu, Satoshi, Didierlaurent, Arnaud, Hussell, Tracy, Ryffel, Bernhard, Erard, Francois
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport Adaptor Proteins, Vesicular Transport - genetics Administration, Intranasal Animals Bronchoalveolar Lavage Fluid Bronchoalveolar Lavage Fluid - cytology Bronchoconstriction Bronchoconstriction - immunology Cell Movement Cell Movement - genetics Cell Movement - immunology Chemokine Chemokines Chemokines - genetics Chemokines - metabolism Cytokines Cytokines - genetics Cytokines - metabolism Epithelial Cells Epithelial Cells - immunology Epithelial Cells - metabolism Epithelium Flagellin Flagellin - immunology Gene Expression Gene Expression - immunology Human health and pathology Humans Immunity, Innate Immunity, Innate - immunology Immunity, Mucosal Immunology Infectious diseases Inflammation Inflammation - immunology Inflammation - metabolism Life Sciences Lung Lung - immunology Lung - metabolism Lung - pathology Lung inflammation Macrophages, Alveolar Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mucosal Tracts Infections Myeloid Differentiation Factor 88 Myeloid Differentiation Factor 88 - genetics Neutrophil Neutrophils Neutrophils - cytology Peroxidase Peroxidase - metabolism Plethysmography, Whole Body Radiation Chimera Radiation Chimera - immunology Radiation Chimera - metabolism Radiation Tolerance Respiratory Mucosa Respiratory Mucosa - immunology Signal Transduction TLR5 Toll-Like Receptor 5 Toll-Like Receptor 5 - deficiency Toll-Like Receptor 5 - genetics Toll-Like Receptor 5 - metabolism
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