A nonparametric method for penetrance function estimation

In diseases caused by a deleterious gene mutation, knowledge of age‐specific cumulative risks is necessary for medical management of mutation carriers. When pedigrees are ascertained through at least one affected individual, ascertainment bias can be corrected by using a parametric method such as th...

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Veröffentlicht in:	Genetic epidemiology 2009-01, Vol.33 (1), p.38-44
Hauptverfasser:	Alarcon, F., Bonaïti-Pellié, C., Harari-Kermadec, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	ascertainment bias Female Genetics Humans Life Sciences Likelihood Functions Male Models, Genetic Models, Statistical Molecular Epidemiology nonparametric method Pedigree Penetrance Phenotype risk estimation Sample Size Statistics, Nonparametric Survival Analysis
Online-Zugang:	Volltext
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