The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering
Abstract In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium...
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| Veröffentlicht in: | Biomaterials 2009-03, Vol.30 (8), p.1568-1577 |
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| creator | Laïb, Samia Fellah, Borhane H Fatimi, Ahmed Quillard, Sophie Vinatier, Claire Gauthier, Olivier Janvier, Pascal Petit, Marc Bujoli, Bruno Bohic, Sylvain Weiss, Pierre |
| description | Abstract In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week. |
| doi_str_mv | 10.1016/j.biomaterials.2008.11.031 |
| format | Article |
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The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2008.11.031</identifier><identifier>PMID: 19101030</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Absorbable Implants ; Advanced Basic Science ; Animals ; Biocompatible Materials - metabolism ; Bioengineering ; Biomaterials ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bone healing ; Calcium Phosphates - metabolism ; Cell Line ; Cell Survival - drug effects ; Cells, Cultured ; Ceramics - metabolism ; Chondrocytes - cytology ; Chondrocytes - drug effects ; Cross-Linking Reagents - pharmacology ; Degradation ; Dentistry ; Femur - pathology ; Femur - ultrastructure ; Fluorescence ; Humans ; Hydrogel ; Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism ; Hypromellose Derivatives ; In vivo test ; Life Sciences ; Methylcellulose - analogs & derivatives ; Methylcellulose - chemistry ; Methylcellulose - metabolism ; N-Acetylneuraminic Acid - chemistry ; N-Acetylneuraminic Acid - metabolism ; Osteogenesis - drug effects ; Prosthesis Implantation ; Rabbits ; Ruthenium - metabolism ; Siloxane ; Time Factors ; Tissue Engineering</subject><ispartof>Biomaterials, 2009-03, Vol.30 (8), p.1568-1577</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-abde0be624bfef50e84cb4accb84c1284c0be12ee44ee0f6c80dbdf54d1ab0513</citedby><cites>FETCH-LOGICAL-c584t-abde0be624bfef50e84cb4accb84c1284c0be12ee44ee0f6c80dbdf54d1ab0513</cites><orcidid>0000-0002-7473-4993 ; 0000-0001-6355-7592 ; 0000-0002-2256-0792 ; 0000-0002-6159-8590 ; 0000-0001-6298-2087 ; 0000-0002-6063-9901</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S014296120800923X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19101030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00352650$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Laïb, Samia</creatorcontrib><creatorcontrib>Fellah, Borhane H</creatorcontrib><creatorcontrib>Fatimi, Ahmed</creatorcontrib><creatorcontrib>Quillard, Sophie</creatorcontrib><creatorcontrib>Vinatier, Claire</creatorcontrib><creatorcontrib>Gauthier, Olivier</creatorcontrib><creatorcontrib>Janvier, Pascal</creatorcontrib><creatorcontrib>Petit, Marc</creatorcontrib><creatorcontrib>Bujoli, Bruno</creatorcontrib><creatorcontrib>Bohic, Sylvain</creatorcontrib><creatorcontrib>Weiss, Pierre</creatorcontrib><title>The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. The results showed that the labelled polysaccharide-based hydrogel was likely to undergo phagocytosis that seemed to occur from the edge to the center of the implantation site up to at least the 8th week.</description><subject>Absorbable Implants</subject><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Biocompatible Materials - metabolism</subject><subject>Bioengineering</subject><subject>Biomaterials</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bone healing</subject><subject>Calcium Phosphates - metabolism</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Ceramics - metabolism</subject><subject>Chondrocytes - cytology</subject><subject>Chondrocytes - drug effects</subject><subject>Cross-Linking Reagents - pharmacology</subject><subject>Degradation</subject><subject>Dentistry</subject><subject>Femur - pathology</subject><subject>Femur - ultrastructure</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Hydrogel</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism</subject><subject>Hypromellose Derivatives</subject><subject>In vivo test</subject><subject>Life Sciences</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - chemistry</subject><subject>Methylcellulose - metabolism</subject><subject>N-Acetylneuraminic Acid - chemistry</subject><subject>N-Acetylneuraminic Acid - metabolism</subject><subject>Osteogenesis - drug effects</subject><subject>Prosthesis Implantation</subject><subject>Rabbits</subject><subject>Ruthenium - metabolism</subject><subject>Siloxane</subject><subject>Time Factors</subject><subject>Tissue Engineering</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P0zAQhiMEYsvCX0AWB06bMHbsbMIBabV8LFIlDiwSN8sfk9YlsYudVOq_x1ErQFyWiz-feWfsd4riFYWKAm3e7CrtwqgmjE4NqWIAbUVpBTV9VKxoe92WogPxuFgB5azsGsouimcp7SDvgbOnxQXtshDUsCrc_RaJ8-TgDoFY3ERl1eSCJ6EnisR52qJ380gGpXEY0JJ9GI5JGbNV0VkstUr5cHu0MWxwIH2IRAePZHIpzUjQb5zHXKjfPC-e9LlcfHGeL4tvHz_c396V6y-fPt_erEsjWj6VSlsEjQ3jusdeALbcaJ4T6rygLA_5ljJEzhGhb0wLVttecEuVBkHry-LqpLtVg9xHN6p4lEE5eXezls4njKMEqAVrBBwW_PUJ38fwc8Y0ydElk9-qPIY5yaZpuWCCPQjWrOso6-BBkEGWE_w6g29PoIkhpYj973IpyMVpuZN_Oy0XpyWlMjudg1-es8x6RPsn9GxtBt6fAMyffXAYZTIOvUHrIppJ2uD-L8-7f2TM4LwzaviBR0y7MEe_xFCZmAT5dem5peWgBehY_b3-BUmC1-g</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Laïb, Samia</creator><creator>Fellah, Borhane H</creator><creator>Fatimi, Ahmed</creator><creator>Quillard, Sophie</creator><creator>Vinatier, Claire</creator><creator>Gauthier, Olivier</creator><creator>Janvier, Pascal</creator><creator>Petit, Marc</creator><creator>Bujoli, Bruno</creator><creator>Bohic, Sylvain</creator><creator>Weiss, Pierre</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7473-4993</orcidid><orcidid>https://orcid.org/0000-0001-6355-7592</orcidid><orcidid>https://orcid.org/0000-0002-2256-0792</orcidid><orcidid>https://orcid.org/0000-0002-6159-8590</orcidid><orcidid>https://orcid.org/0000-0001-6298-2087</orcidid><orcidid>https://orcid.org/0000-0002-6063-9901</orcidid></search><sort><creationdate>20090301</creationdate><title>The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering</title><author>Laïb, Samia ; 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The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and 8 weeks after surgery, the bone explants were analyzed by synchrotron X-ray microfluorescence, infrared mapping spectroscopy, scanning electron microscopy, and optical microscopy after histological coloration. 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| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2009-03, Vol.30 (8), p.1568-1577 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Absorbable Implants Advanced Basic Science Animals Biocompatible Materials - metabolism Bioengineering Biomaterials Bone and Bones - drug effects Bone and Bones - metabolism Bone healing Calcium Phosphates - metabolism Cell Line Cell Survival - drug effects Cells, Cultured Ceramics - metabolism Chondrocytes - cytology Chondrocytes - drug effects Cross-Linking Reagents - pharmacology Degradation Dentistry Femur - pathology Femur - ultrastructure Fluorescence Humans Hydrogel Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism Hypromellose Derivatives In vivo test Life Sciences Methylcellulose - analogs & derivatives Methylcellulose - chemistry Methylcellulose - metabolism N-Acetylneuraminic Acid - chemistry N-Acetylneuraminic Acid - metabolism Osteogenesis - drug effects Prosthesis Implantation Rabbits Ruthenium - metabolism Siloxane Time Factors Tissue Engineering |
| title | The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering |
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