Dysregulation of elastin expression by fibroblasts in pulmonary emphysema: role of cellular retinoic acid binding protein 2

Background:All-trans retinoic acid (ATRA) stimulates elastin synthesis by lung fibroblasts and induces alveolar regeneration in animal models of pulmonary emphysema. However, ATRA treatment has had disappointing results in human emphysema. It was hypothesised that a defect in the ATRA signalling pat...

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Veröffentlicht in:	Thorax 2008-11, Vol.63 (11), p.1012-1017
Hauptverfasser:	Plantier, L, Rochette-Egly, C, Goven, D, Boutten, A, Bonay, M, Lesèche, G, Fournier, M, Crestani, B, Boczkowski, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibodies Biological and medical sciences Cardiology. Vascular system Case-Control Studies Cell culture Cells, Cultured Chronic obstructive pulmonary disease, asthma Elastin Elastin - metabolism Emphysema Ethics Fibroblasts Fibroblasts - metabolism Humans Life Sciences Lung diseases Medical sciences Middle Aged Pneumology Proteins Pulmonary Emphysema Pulmonary Emphysema - metabolism Receptors, Retinoic Acid Receptors, Retinoic Acid - metabolism Receptors, Retinoic Acid - physiology RNA, Messenger RNA, Messenger - metabolism Smooth muscle
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