Changes in action potentials and intracellular ionic homeostasis in a ventricular cell model related to a persistent sodium current in SCN5A mutations underlying LQT3

In LQT3 patients, SCN5A mutations induce ultraslow inactivation of a small fraction of the hNav1.5 current, i.e. persistent Na + current ( I pNa). We explored the time course of effects of such a change on the intracellular ionic homeostasis in a model of guinea-pig cardiac ventricular cell [Pasek,...

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Veröffentlicht in:	Progress in biophysics and molecular biology 2008-01, Vol.96 (1), p.281-293
Hauptverfasser:	Christé, G., Chahine, M., Chevalier, P., Pásek, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - genetics Animals Cardiology and cardiovascular system Computer Science Heart Ventricles - cytology Homeostasis - genetics Human health and pathology Humans Intracellular Fluid - metabolism Intracellular Fluid - physiology Life Sciences Long QT syndrome Long QT Syndrome - genetics Long QT Syndrome - metabolism Modeling and Simulation Models, Cardiovascular Mutation Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology NAV1.5 Voltage-Gated Sodium Channel SCN5A Sodium - physiology Sodium Channels - genetics Sodium Channels - metabolism Sudden death Ventricular Function
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