In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel

Paclitaxel-loaded lipid nanocapsules (PX-LNC) exhibit interesting in vitro characteristics with improved antitumoral activity compared with free PX formulation. Biodistribution studies were realized with the use of 14C-trimyristin ( 14C-TM) or 14C-phosphatidylcholine ( 14C-PC) whereas antitumoral ac...

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Veröffentlicht in:	International journal of pharmaceutics 2007-11, Vol.344 (1), p.143-149
Hauptverfasser:	Lacoeuille, F., Hindre, F., Moal, F., Roux, J., Passirani, C., Couturier, O., Cales, P., Le Jeune, J.J., Lamprecht, A., Benoit, J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacokinetics Antineoplastic Agents, Phytogenic - therapeutic use Area Under Curve Biodistribution Bioengineering Biological and medical sciences Biological Availability Biomaterials Biotechnology Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - mortality Colloids Computer Science Drug Carriers Drug Compounding Drug delivery system General pharmacology Half-Life Hepatocellular carcinoma Life Sciences Lipid nanocapsules Lipids Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - drug therapy Liver Neoplasms, Experimental - mortality Medical sciences Nanocapsules Paclitaxel Paclitaxel - administration & dosage Paclitaxel - pharmacokinetics Paclitaxel - therapeutic use Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Wistar Survival Rate
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