The secreted autotransporter toxin, Sat, functions as a virulence factor in Afa/Dr diffusely adhering Escherichia coli by promoting lesions in tight junction of polarized epithelial cells

Summary Afa/Dr diffusely adhering Escherichia coli (DAEC) strains are responsible for urinary tract and intestinal infections. Both in intestine and kidney, the epithelial cells forming epithelium are sealed by junctional domains. We provide evidence that the Secreted autotransporter toxin, Sat, bel...

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Veröffentlicht in:	Cellular microbiology 2007-01, Vol.9 (1), p.204-221
Hauptverfasser:	Guignot, Julie, Chaplais, Cécile, Coconnier‐Polter, Marie‐Hélène, Servin, Alain L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - metabolism Adhesins, Escherichia coli Adhesins, Escherichia coli - metabolism Amino Acid Motifs Bacterial Adhesion Bacterial Toxins Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - metabolism Caco-2 Cells Child Diarrhea Diarrhea - microbiology Enterobacteriaceae Epithelial Cells Epithelial Cells - cytology Epithelial Cells - microbiology Escherichia coli Escherichia coli - pathogenicity Escherichia coli Infections Escherichia coli Infections - microbiology Escherichia coli Proteins Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Feces Feces - microbiology Human health and pathology Humans Infectious diseases Life Sciences Microbiology and Parasitology Mutagenesis, Site-Directed Serine Endopeptidases Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Tight Junctions Tight Junctions - metabolism Tight Junctions - ultrastructure Urinary Tract Infections Urinary Tract Infections - microbiology Virulence Factors Virulence Factors - metabolism
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