Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

CONTEXT Identification and replication of susceptibility genes for Parkinson disease at the population level have been hampered by small studies with potential biases. α-Synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking. OBJECTIVE To...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2006-08, Vol.296 (6), p.661-670
Hauptverfasser:	Maraganore, Demetrius M, de Andrade, Mariza, Elbaz, Alexis, Farrer, Matthew J, Ioannidis, John P, Krüger, Rejko, Rocca, Walter A, Schneider, Nicole K, Lesnick, Timothy G, Lincoln, Sarah J, Hulihan, Mary M, Aasly, Jan O, Ashizawa, Tetsuo, Chartier-Harlin, Marie-Christine, Checkoway, Harvey, Ferrarese, Carlo, Hadjigeorgiou, Georgios, Hattori, Nobutaka, Kawakami, Hideshi, Lambert, Jean-Charles, Lynch, Timothy, Mellick, George D, Papapetropoulos, Spiridon, Parsian, Abbas, Quattrone, Aldo, Riess, Olaf, Tan, Eng-King, Van Broeckhoven, Christine, Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium, for the
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Aged, 80 and over Alleles alpha-Synuclein alpha-Synuclein - genetics Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dinucleotide Repeats Female General aspects Genes Genetic Predisposition to Disease Genetic Variation Genotype Haplotypes Humans Life Sciences Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Neurons and Cognition Parkinson Disease Parkinson Disease - epidemiology Parkinson Disease - genetics Parkinson's disease Promoter Regions (Genetics) Promoter Regions, Genetic Risk factors Santé publique et épidémiologie Variation (Genetics)
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