In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

Insulin-secreting pancreatic beta cells are exceptionally rich in zinc. In these cells, zinc is required for zinc-insulin crystallization within secretory vesicles. Secreted zinc has also been proposed to be a paracrine and autocrine modulator of glucagon and insulin secretion in pancreatic alpha an...

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Veröffentlicht in:	Journal of cell science 2006-10, Vol.119 (Pt 20), p.4199-4206
Hauptverfasser:	Chimienti, Fabrice, Devergnas, Séverine, Pattou, François, Schuit, Frans, Garcia-Cuenca, Rachel, Vandewalle, Brigitte, Kerr-Conte, Julie, Van Lommel, Leentje, Grunwald, Didier, Favier, Alain, Seve, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Biological Transport - drug effects Cancer Cation Transport Proteins Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cation Transport Proteins - physiology Cell Line Cell Membrane Cell Membrane - drug effects Cell Membrane - metabolism Cell Survival Cell Survival - drug effects Dose-Response Relationship, Drug Gene Expression Gene Expression - drug effects Gene Expression - genetics Glucagon Glucagon - metabolism Glucose Glucose - pharmacology Green Fluorescent Proteins Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HeLa Cells Humans Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Islets of Langerhans Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Life Sciences Male Mice Microscopy, Confocal Microscopy, Fluorescence Models, Biological Recombinant Fusion Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Secretory Vesicles Secretory Vesicles - drug effects Secretory Vesicles - metabolism Zinc Zinc - metabolism Zinc - pharmacology Zinc Transporter 8
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