Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies: hCG signaling is impaired in trisomy 21 pregnancy

Placental development is markedly abnormal in women bearing a fetus with trisomy 21, with defective syncytiotrophoblast (ST) formation and function. The ST occurs from cytotrophoblast (CT) fusion and plays an essential role by secreting human chorionic gonadotropin (hCG), which is essential to place...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2007-11, Vol.148 (11), p.5403-13
Hauptverfasser:	Pidoux, Guillaume, Gerbaud, Pascale, Marpeau, Olivier, Guibourdenche, Jean, Ferreira, Fatima, Badet, Josette, Evain-Brion, Danièle, Frendo, Jean-Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chorionic Gonadotropin Down Syndrome Female Humans Life Sciences Models, Biological Placentation Pregnancy Pregnancy Complications Receptors, LH Reproductive Biology Signal Transduction Trophoblasts
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