Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy

Intravitreal neovascular diseases, as in ischemic retinopathies, are a major cause of blindness. Because inflammatory mechanisms influence vitreal neovascularization and cyclooxygenase (COX)-2 promotes tumor angiogenesis, we investigated the role of COX-2 in ischemic proliferative retinopathy. We de...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-07, Vol.108 (2), p.198-204
Hauptverfasser:	SENNLAUB, F, VALAMANESH, F, GEBOES, K, VARMA, D. R, LACHAPELLE, P, ONG, H, BEHAR-COHEN, F, CHEMTOB, S, VAZQUEZ-TELLO, A, EL-ASRAR, A. M, CHECCHIN, D, BRAULT, S, GOBEIL, F, BEAUCHAMP, M. H, MWAIKAMBO, B, COURTOIS, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antigens, CD36 Astrocytes Astrocytes - drug effects Astrocytes - enzymology Astrocytes - pathology Biological and medical sciences CD36 Antigens - metabolism Cell Division Cell Division - drug effects Cells, Cultured Cyclooxygenase 2 Diabetic Retinopathy Diabetic Retinopathy - complications Diabetic Retinopathy - drug therapy Diabetic Retinopathy - enzymology Diabetic Retinopathy - pathology Dinoprostone Dinoprostone - metabolism Disease Models, Animal Endothelial Growth Factors Endothelial Growth Factors - metabolism Enzyme Inhibitors Enzyme Inhibitors - pharmacology Female Humans Intercellular Signaling Peptides Intercellular Signaling Peptides and Proteins - metabolism Ischemia - complications Ischemia - enzymology Ischemia - pathology Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Life Sciences Lymphokines - metabolism Male Medical sciences Membrane Proteins Mice Mice, Inbred C57BL Middle Aged Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Neurons and Cognition Ophthalmology Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley Receptors, Immunologic Receptors, Lipoprotein - metabolism Receptors, Prostaglandin E - drug effects Receptors, Prostaglandin E - metabolism Receptors, Prostaglandin E, EP3 Subtype Receptors, Prostaglandin E, EP4 Subtype Receptors, Scavenger Retina - drug effects Retina - enzymology Retina - pathology Retinal Vessels - drug effects Retinal Vessels - pathology Retinopathies Thrombospondin 1 - metabolism Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular Endothelial Growth Factors Vitreoretinopathy, Proliferative - complications Vitreoretinopathy, Proliferative - drug therapy Vitreoretinopathy, Proliferative - enzymology Vitreoretinopathy, Proliferative - pathology
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