The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila
The bric à brac ( bab ) locus acts as a homeotic and morphogenetic regulator in the development of ovaries, appendages and the abdomen. It consists of two structurally and functionally related genes, bab1 and bab2 , each of which encodes a single nuclear protein. Bab1 and Bab2 have two conserved do...
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| Veröffentlicht in: | Development (Cambridge) 2002-05, Vol.129 (10), p.2419-2433 |
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| container_title | Development (Cambridge) |
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| creator | Couderc, Jean-Louis Godt, Dorothea Zollman, Susan Chen, Jiong Li, Michelle Tiong, Stanley Cramton, Sarah E Sahut-Barnola, Isabelle Laski, Frank A |
| description | The bric à brac ( bab ) locus acts as a homeotic and morphogenetic regulator in the development of ovaries, appendages and the abdomen. It consists of two structurally and functionally related genes, bab1 and bab2 , each of which encodes a single nuclear protein. Bab1 and Bab2 have two conserved domains in common, a BTB/POZ domain and a Psq domain, a motif that characterizes a subfamily of BTB/POZ domain proteins in Drosophila . The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2. Analysis of a series of mutations indicates that the two bab genes have synergistic, distinct and redundant functions during imaginal development. Interestingly, several reproduction-related traits that are sexually dimorphic or show diversity among Drosophila species are highly sensitive to changes in the bab gene dose, suggesting that alterations in bab activity may contribute to evolutionary modification of sex-related morphology. |
| doi_str_mv | 10.1242/dev.129.10.2419 |
| format | Article |
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It consists of two structurally and functionally related genes, bab1 and bab2 , each of which encodes a single nuclear protein. Bab1 and Bab2 have two conserved domains in common, a BTB/POZ domain and a Psq domain, a motif that characterizes a subfamily of BTB/POZ domain proteins in Drosophila . The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2. Analysis of a series of mutations indicates that the two bab genes have synergistic, distinct and redundant functions during imaginal development. Interestingly, several reproduction-related traits that are sexually dimorphic or show diversity among Drosophila species are highly sensitive to changes in the bab gene dose, suggesting that alterations in bab activity may contribute to evolutionary modification of sex-related morphology.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.129.10.2419</identifier><identifier>PMID: 11973274</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>Abdomen ; Abdomen - growth & development ; Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; bab1 gene ; bab2 gene ; Body Patterning ; bric a brac (bab) gene ; BTB/POZ domain proteins ; Chromosome Mapping ; Development Biology ; DNA-Binding Proteins ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drosophila ; Drosophila - genetics ; Drosophila Proteins ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Extremities ; Extremities - growth & development ; Female ; Gene Expression Regulation, Developmental ; Genitalia ; Genitalia, Female ; Genitalia, Female - growth & development ; Genitalia, Male - growth & development ; Larva ; Life Sciences ; Male ; Molecular Sequence Data ; Mutation ; Ovary - abnormalities ; Ovary - growth & development ; Protein Structure, Tertiary ; Repressor Proteins - chemistry ; Sequence Homology, Amino Acid ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Development (Cambridge), 2002-05, Vol.129 (10), p.2419-2433</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-19a14aba112e2c132a2e5fa36257e8df80c5a459d4e75b602494888a51a8fef63</citedby><cites>FETCH-LOGICAL-c400t-19a14aba112e2c132a2e5fa36257e8df80c5a459d4e75b602494888a51a8fef63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11973274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00139701$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Couderc, Jean-Louis</creatorcontrib><creatorcontrib>Godt, Dorothea</creatorcontrib><creatorcontrib>Zollman, Susan</creatorcontrib><creatorcontrib>Chen, Jiong</creatorcontrib><creatorcontrib>Li, Michelle</creatorcontrib><creatorcontrib>Tiong, Stanley</creatorcontrib><creatorcontrib>Cramton, Sarah E</creatorcontrib><creatorcontrib>Sahut-Barnola, Isabelle</creatorcontrib><creatorcontrib>Laski, Frank A</creatorcontrib><title>The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The bric à brac ( bab ) locus acts as a homeotic and morphogenetic regulator in the development of ovaries, appendages and the abdomen. It consists of two structurally and functionally related genes, bab1 and bab2 , each of which encodes a single nuclear protein. Bab1 and Bab2 have two conserved domains in common, a BTB/POZ domain and a Psq domain, a motif that characterizes a subfamily of BTB/POZ domain proteins in Drosophila . The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2. Analysis of a series of mutations indicates that the two bab genes have synergistic, distinct and redundant functions during imaginal development. Interestingly, several reproduction-related traits that are sexually dimorphic or show diversity among Drosophila species are highly sensitive to changes in the bab gene dose, suggesting that alterations in bab activity may contribute to evolutionary modification of sex-related morphology.</description><subject>Abdomen</subject><subject>Abdomen - growth & development</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>bab1 gene</subject><subject>bab2 gene</subject><subject>Body Patterning</subject><subject>bric a brac (bab) gene</subject><subject>BTB/POZ domain proteins</subject><subject>Chromosome Mapping</subject><subject>Development Biology</subject><subject>DNA-Binding Proteins</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Extremities</subject><subject>Extremities - growth & development</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genitalia</subject><subject>Genitalia, Female</subject><subject>Genitalia, Female - growth & development</subject><subject>Genitalia, Male - growth & development</subject><subject>Larva</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Ovary - abnormalities</subject><subject>Ovary - growth & development</subject><subject>Protein Structure, Tertiary</subject><subject>Repressor Proteins - chemistry</subject><subject>Sequence Homology, Amino Acid</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQjRCILoUzN-QTJ3bXdj4cH9tSKNJK5bBcuFizziQxSuJgZ1tx5o_0P_AP4I8x0UYgTkiWPDN-fjNvXpK8FHwjZCa3Fd5RoDeUy0zoR8lKZEqtNdUeJyuuc74WWouz5FmMXzjnaaHU0-RMCK1SqbJV8mPfIjsEZ9mv7z8fKALLOm-PkVk_RBenyHzNpnvPRgjQ-cbTU4MDRoaD9ZUbGna5v9x-vP3MKt-DG9gY_IRuiAyGioElBqDDWt-jn6jRXO59GFs_88yVgM2xg8mHuZfroXEDdIy0YefHHoeJEe3b4KMfW9fB8-RJDV3EF8t9nnx6d72_ulnvbt9_uLrYrW3G-UTCQWRwACEkSitSCRLzGtJC5grLqi65zSHLdZWhyg8Fl5nOyrKEXEBZY12k58mbE28LnRkDDRa-GQ_O3FzsDAnE0BvORaoVF3eC4K9PcFrA1yPGyfQuWuw6GJC2ZpQohM7z_wNFmcqyUDNwewJa0h4D1n-mENzM_hvaEQV6zmf_6cerhfp46LH6i18MJ8Bm0eSa9t4FNAfnydbZabNs_B_G34uMv4s</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Couderc, Jean-Louis</creator><creator>Godt, Dorothea</creator><creator>Zollman, Susan</creator><creator>Chen, Jiong</creator><creator>Li, Michelle</creator><creator>Tiong, Stanley</creator><creator>Cramton, Sarah E</creator><creator>Sahut-Barnola, Isabelle</creator><creator>Laski, Frank A</creator><general>The Company of Biologists Limited</general><general>Company of Biologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20020501</creationdate><title>The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila</title><author>Couderc, Jean-Louis ; Godt, Dorothea ; Zollman, Susan ; Chen, Jiong ; Li, Michelle ; Tiong, Stanley ; Cramton, Sarah E ; Sahut-Barnola, Isabelle ; Laski, Frank A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-19a14aba112e2c132a2e5fa36257e8df80c5a459d4e75b602494888a51a8fef63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abdomen</topic><topic>Abdomen - growth & development</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>bab1 gene</topic><topic>bab2 gene</topic><topic>Body Patterning</topic><topic>bric a brac (bab) gene</topic><topic>BTB/POZ domain proteins</topic><topic>Chromosome Mapping</topic><topic>Development Biology</topic><topic>DNA-Binding Proteins</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Extremities</topic><topic>Extremities - growth & development</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genitalia</topic><topic>Genitalia, Female</topic><topic>Genitalia, Female - growth & development</topic><topic>Genitalia, Male - growth & development</topic><topic>Larva</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Ovary - abnormalities</topic><topic>Ovary - growth & development</topic><topic>Protein Structure, Tertiary</topic><topic>Repressor Proteins - chemistry</topic><topic>Sequence Homology, Amino Acid</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Couderc, Jean-Louis</creatorcontrib><creatorcontrib>Godt, Dorothea</creatorcontrib><creatorcontrib>Zollman, Susan</creatorcontrib><creatorcontrib>Chen, Jiong</creatorcontrib><creatorcontrib>Li, Michelle</creatorcontrib><creatorcontrib>Tiong, Stanley</creatorcontrib><creatorcontrib>Cramton, Sarah E</creatorcontrib><creatorcontrib>Sahut-Barnola, Isabelle</creatorcontrib><creatorcontrib>Laski, Frank A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Couderc, Jean-Louis</au><au>Godt, Dorothea</au><au>Zollman, Susan</au><au>Chen, Jiong</au><au>Li, Michelle</au><au>Tiong, Stanley</au><au>Cramton, Sarah E</au><au>Sahut-Barnola, Isabelle</au><au>Laski, Frank A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>129</volume><issue>10</issue><spage>2419</spage><epage>2433</epage><pages>2419-2433</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The bric à brac ( bab ) locus acts as a homeotic and morphogenetic regulator in the development of ovaries, appendages and the abdomen. It consists of two structurally and functionally related genes, bab1 and bab2 , each of which encodes a single nuclear protein. Bab1 and Bab2 have two conserved domains in common, a BTB/POZ domain and a Psq domain, a motif that characterizes a subfamily of BTB/POZ domain proteins in Drosophila . The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2. Analysis of a series of mutations indicates that the two bab genes have synergistic, distinct and redundant functions during imaginal development. Interestingly, several reproduction-related traits that are sexually dimorphic or show diversity among Drosophila species are highly sensitive to changes in the bab gene dose, suggesting that alterations in bab activity may contribute to evolutionary modification of sex-related morphology.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>11973274</pmid><doi>10.1242/dev.129.10.2419</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2002-05, Vol.129 (10), p.2419-2433 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_inserm_00139701v1 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Abdomen Abdomen - growth & development Amino Acid Sequence Animals Animals, Genetically Modified bab1 gene bab2 gene Body Patterning bric a brac (bab) gene BTB/POZ domain proteins Chromosome Mapping Development Biology DNA-Binding Proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila Drosophila - genetics Drosophila Proteins Drosophila Proteins - genetics Drosophila Proteins - metabolism Extremities Extremities - growth & development Female Gene Expression Regulation, Developmental Genitalia Genitalia, Female Genitalia, Female - growth & development Genitalia, Male - growth & development Larva Life Sciences Male Molecular Sequence Data Mutation Ovary - abnormalities Ovary - growth & development Protein Structure, Tertiary Repressor Proteins - chemistry Sequence Homology, Amino Acid Transcription Factors - genetics Transcription Factors - metabolism |
| title | The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila |
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