Efficient, protection-free Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles

Efficient, protection-free Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles

We describe an efficient protocol for the Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. We describe an efficient protocol for the Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and...

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Veröffentlicht in:Tetrahedron letters 2005-09, Vol.46 (38), p.6529-6532
Hauptverfasser: Cousaert, Nicolas, Toto, Patrick, Willand, Nicolas, Deprez, Benoît
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Sprache:eng
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Life Sciences
Microwave synthesis
ortho-Biphenyltetrazole
Pharmaceutical sciences
Suzuki–Miyaura cross-coupling
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container_end_page 6532
container_issue 38
container_start_page 6529
container_title Tetrahedron letters
container_volume 46
creator Cousaert, Nicolas
Toto, Patrick
Willand, Nicolas
Deprez, Benoît
description We describe an efficient protocol for the Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. We describe an efficient protocol for the Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles from non-protected 2-bromophenyltetrazole and arylboronic acids. The optimised conditions were achieved using [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) as catalyst and Na 2CO 3 as base. A panel of structurally diverse arylboronic acids was used to demonstrate the scope of the coupling procedure.
doi_str_mv 10.1016/j.tetlet.2005.07.082
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subjects Life Sciences
Microwave synthesis
ortho-Biphenyltetrazole
Pharmaceutical sciences
Suzuki–Miyaura cross-coupling
title Efficient, protection-free Suzuki–Miyaura synthesis of ortho-biphenyltetrazoles
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