PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop

Information on toxicokinetics is critical for animal-free human risk assessment. Human external exposure must be translated into human tissue doses and compared with in vitro actual cell exposure associated to effects (in vitro-in vivo comparison). Data on absorption, distribution, metabolism and ex...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2014-02, Vol.68 (1), p.119-139
Hauptverfasser:	Bessems, Jos G, Loizou, George, Krishnan, Kannan, Clewell, 3rd, Harvey J, Bernasconi, Camilla, Bois, Frederic, Coecke, Sandra, Collnot, Eva-Maria, Diembeck, Walter, Farcal, Lucian Romeo, Geraets, Liesbeth, Gundert-Remy, Ursula, Kramer, Nynke, Küsters, Gabriele, Leite, Sofia B, Pelkonen, Olavi R, Schröder, Klaus, Testai, Emanuela, Wilk-Zasadna, Iwona, Zaldívar-Comenges, José-Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Drug-Related Side Effects and Adverse Reactions Environmental Exposure - adverse effects Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Humans Life Sciences Models, Biological Pharmacokinetics Risk Assessment Toxicology
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