Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

► Toxicokinetics (TK) is a key element to integrate the results from in silico, in vitro and in vivo studies. ► TK is needed to estimate target organ doses expected from realistic human external exposure scenarios. ► TK is necessary for quantitative in vitro–in vivo extrapolation (IVIVE). ► Physiolo...

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Veröffentlicht in:	Toxicology in vitro 2013-08, Vol.27 (5), p.1570-1577
Hauptverfasser:	Coecke, Sandra, Pelkonen, Olavi, Leite, Sofia Batista, Bernauer, Ulrike, Bessems, Jos GM, Bois, Frederic Y., Gundert-Remy, Ursula, Loizou, George, Testai, Emanuela, Zaldívar, José-Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	ADME Alternative methods validation Animal Testing Alternatives Animals Computer Simulation Environmental Sciences Humans In silico In vitro Life Sciences Models, Biological Pharmacokinetics Physiologically based toxicokinetic modelling Risk Assessment Toxicology
Online-Zugang:	Volltext
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