Biology-Based Modeling To Analyze Uranium Toxicity Data on Daphnia magna in a Multigeneration Study
Recent studies have investigated chronic toxicity of waterborne depleted uranium on the life cycle and physiology of Daphnia magna. In particular, a reduction in food assimilation was observed. Our aims here were to examine whether this reduction could fully account for observed effects on both grow...
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| Veröffentlicht in: | Environmental science & technology 2011-05, Vol.45 (9), p.4151-4158 |
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| creator | Massarin, Sandrine Beaudouin, Remy Zeman, Florence Floriani, Magali Gilbin, Rodolphe Alonzo, Frederic Pery, Alexandre R. R |
| description | Recent studies have investigated chronic toxicity of waterborne depleted uranium on the life cycle and physiology of Daphnia magna. In particular, a reduction in food assimilation was observed. Our aims here were to examine whether this reduction could fully account for observed effects on both growth and reproduction, for three successive generations, and to investigate through microscope analyses whether this reduction resulted from direct damage to the intestinal epithelium. We analyzed data obtained by exposing Daphnia magna to uranium over three successive generations. We used energy-based models, which are both able to fit simultaneously growth and reproduction and are biologically relevant. Two possible modes of action were compared − decrease in food assimilation rate and increase in maintenance costs. In our models, effects were related either to internal concentration or to exposure concentration. The model that fitted the data best represented a decrease in food assimilation related to exposure concentration. Furthermore, observations of consequent histological damage to the intestinal epithelium, together with uranium precipitates in the epithelial cells, supported the assumption that uranium has direct effects on the digestive tract. We were able to model the data in all generations and showed that sensitivity increased from one generation to the next, in particular through a significant increase of the intensity of effect, once the threshold for appearance of effects was exceeded. |
| doi_str_mv | 10.1021/es104082e |
| format | Article |
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Two possible modes of action were compared − decrease in food assimilation rate and increase in maintenance costs. In our models, effects were related either to internal concentration or to exposure concentration. The model that fitted the data best represented a decrease in food assimilation related to exposure concentration. Furthermore, observations of consequent histological damage to the intestinal epithelium, together with uranium precipitates in the epithelial cells, supported the assumption that uranium has direct effects on the digestive tract. We were able to model the data in all generations and showed that sensitivity increased from one generation to the next, in particular through a significant increase of the intensity of effect, once the threshold for appearance of effects was exceeded.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es104082e</identifier><identifier>PMID: 21469640</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Crustaceans ; Daphnia - drug effects ; Daphnia - growth & development ; Ecotoxicology and Human Environmental Health ; Ecotoxicology, biological effects of pollution ; Environmental Exposure - adverse effects ; Environmental Sciences ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects. 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R</creatorcontrib><title>Biology-Based Modeling To Analyze Uranium Toxicity Data on Daphnia magna in a Multigeneration Study</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>Recent studies have investigated chronic toxicity of waterborne depleted uranium on the life cycle and physiology of Daphnia magna. In particular, a reduction in food assimilation was observed. Our aims here were to examine whether this reduction could fully account for observed effects on both growth and reproduction, for three successive generations, and to investigate through microscope analyses whether this reduction resulted from direct damage to the intestinal epithelium. We analyzed data obtained by exposing Daphnia magna to uranium over three successive generations. We used energy-based models, which are both able to fit simultaneously growth and reproduction and are biologically relevant. Two possible modes of action were compared − decrease in food assimilation rate and increase in maintenance costs. In our models, effects were related either to internal concentration or to exposure concentration. The model that fitted the data best represented a decrease in food assimilation related to exposure concentration. Furthermore, observations of consequent histological damage to the intestinal epithelium, together with uranium precipitates in the epithelial cells, supported the assumption that uranium has direct effects on the digestive tract. 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Techniques</topic><topic>Histology</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>Life Sciences</topic><topic>Methods and techniques (sampling, tagging, trapping, modelling...)</topic><topic>Microscopy</topic><topic>Models, Biological</topic><topic>Physiology</topic><topic>Reproduction</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Uranium</topic><topic>Uranium - toxicity</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Massarin, Sandrine</creatorcontrib><creatorcontrib>Beaudouin, Remy</creatorcontrib><creatorcontrib>Zeman, Florence</creatorcontrib><creatorcontrib>Floriani, Magali</creatorcontrib><creatorcontrib>Gilbin, Rodolphe</creatorcontrib><creatorcontrib>Alonzo, Frederic</creatorcontrib><creatorcontrib>Pery, Alexandre R. 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R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biology-Based Modeling To Analyze Uranium Toxicity Data on Daphnia magna in a Multigeneration Study</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>45</volume><issue>9</issue><spage>4151</spage><epage>4158</epage><pages>4151-4158</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>Recent studies have investigated chronic toxicity of waterborne depleted uranium on the life cycle and physiology of Daphnia magna. In particular, a reduction in food assimilation was observed. Our aims here were to examine whether this reduction could fully account for observed effects on both growth and reproduction, for three successive generations, and to investigate through microscope analyses whether this reduction resulted from direct damage to the intestinal epithelium. 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| subjects | Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Crustaceans Daphnia - drug effects Daphnia - growth & development Ecotoxicology and Human Environmental Health Ecotoxicology, biological effects of pollution Environmental Exposure - adverse effects Environmental Sciences Fundamental and applied biological sciences. Psychology General aspects General aspects. Techniques Histology Intestinal Mucosa - drug effects Intestinal Mucosa - ultrastructure Life Sciences Methods and techniques (sampling, tagging, trapping, modelling...) Microscopy Models, Biological Physiology Reproduction Toxicity Toxicology Uranium Uranium - toxicity Water Pollutants, Chemical - toxicity |
| title | Biology-Based Modeling To Analyze Uranium Toxicity Data on Daphnia magna in a Multigeneration Study |
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