Low-Threshold Mechanoreceptor Subtypes Selectively Express MafA and Are Specified by Ret Signaling

Low-threshold mechanoreceptor neurons (LTMs) of the dorsal root ganglia (DRG) are essential for touch sensation. They form highly specialized terminations in the skin and display stereotyped projections in the spinal cord. Functionally defined LTMs depend on neurotrophin signaling for their postnata...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2009-12, Vol.64 (6), p.857-870
Hauptverfasser:	Bourane, Steeve, Garces, Alain, Venteo, Stephanie, Pattyn, Alexandre, Hubert, Thomas, Fichard, Agnes, Puech, Sylvie, Boukhaddaoui, Hassan, Baudet, Christel, Takahashi, Satoru, Valmier, Jean, Carroll, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Afferent Pathways - cytology Afferent Pathways - embryology Afferent Pathways - metabolism Animals Cell Differentiation - genetics CELLBIO DEVBIO Ganglia, Spinal - cytology Ganglia, Spinal - embryology Ganglia, Spinal - metabolism Gene expression Gene Expression Regulation, Developmental - genetics Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism Kinases Life Sciences Ligands Maf Transcription Factors, Large - genetics Maf Transcription Factors, Large - metabolism Mechanoreceptors - cytology Mechanoreceptors - metabolism Mice Mice, Knockout Mice, Transgenic MOLNEURO Mutation - genetics Nerve Growth Factors - genetics Nerve Growth Factors - metabolism Neurogenesis - genetics Neurons Population Proteins Proto-Oncogene Proteins c-ret - genetics Proto-Oncogene Proteins c-ret - metabolism Sensory Receptor Cells - cytology Sensory Receptor Cells - metabolism Sensory Thresholds - physiology Signal Transduction - genetics Skin Spinal cord Touch - physiology Transcription factors
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