Dual role for prostaglandin D2 in intestinal epithelial homeostasis
Prostaglandin D2 (PGD2) and derivatives are lipid mediators involved in the control of the intestinal epithelial barrier homeostasis. Their involvement in the pathophysiology of chronic inflammatory bowel disease (IBD) is still debated. Several results highlight the duality of PGD2 as an anti- or pr...
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| Veröffentlicht in: | M.S. Médecine sciences 2015-06, Vol.31 (6-7), p.617-621 |
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| container_title | M.S. Médecine sciences |
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| creator | Le Loupp, Anne-Gaelle Bach-Ngohou, Kalyane Bettan, Armel Denis, Marc Masson, Damien |
| description | Prostaglandin D2 (PGD2) and derivatives are lipid mediators involved in the control of the intestinal epithelial barrier homeostasis. Their involvement in the pathophysiology of chronic inflammatory bowel disease (IBD) is still debated. Several results highlight the duality of PGD2 as an anti- or pro-inflammatory mediator. This duality seems to be related to a differential expression of its receptors by intestinal epithelial cells and the surrounding immunocompetent cells. The enteric glial cells from the enteric nervous system (ENS) express the lipocalin-type-prostaglandin D synthase and secrete PGD2 and 15d-PGJ2. The protective role of the ENS in the homeostatic control of the epithelial intestinal barrier and its involvement in the pathogenesis of IBD have already been demonstrated. Thus, these lipid mediators seem to be new actors of the neuro-glio-epithelial unit and could play a crucial role maintaining gut barrier integrity. |
| doi_str_mv | 10.1051/medsci/20153106014 |
| format | Article |
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Their involvement in the pathophysiology of chronic inflammatory bowel disease (IBD) is still debated. Several results highlight the duality of PGD2 as an anti- or pro-inflammatory mediator. This duality seems to be related to a differential expression of its receptors by intestinal epithelial cells and the surrounding immunocompetent cells. The enteric glial cells from the enteric nervous system (ENS) express the lipocalin-type-prostaglandin D synthase and secrete PGD2 and 15d-PGJ2. The protective role of the ENS in the homeostatic control of the epithelial intestinal barrier and its involvement in the pathogenesis of IBD have already been demonstrated. Thus, these lipid mediators seem to be new actors of the neuro-glio-epithelial unit and could play a crucial role maintaining gut barrier integrity.</description><identifier>ISSN: 0767-0974</identifier><identifier>EISSN: 1958-5381</identifier><identifier>DOI: 10.1051/medsci/20153106014</identifier><identifier>PMID: 26152165</identifier><language>eng ; fre</language><publisher>France: EDP Sciences</publisher><subject>Animals ; Epithelial Cells ; Epithelial Cells - physiology ; Homeostasis ; Homeostasis - physiology ; Human health and pathology ; Humans ; Inflammatory Bowel Diseases ; Inflammatory Bowel Diseases - etiology ; Inflammatory Bowel Diseases - pathology ; Intestinal Mucosa ; Intestinal Mucosa - physiology ; Life Sciences ; Lipids ; Lipids - pharmacology ; Paracrine Communication ; Prostaglandin D2 ; Prostaglandin D2 - physiology</subject><ispartof>M.S. 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Médecine sciences</title><addtitle>Med Sci (Paris)</addtitle><description>Prostaglandin D2 (PGD2) and derivatives are lipid mediators involved in the control of the intestinal epithelial barrier homeostasis. Their involvement in the pathophysiology of chronic inflammatory bowel disease (IBD) is still debated. Several results highlight the duality of PGD2 as an anti- or pro-inflammatory mediator. This duality seems to be related to a differential expression of its receptors by intestinal epithelial cells and the surrounding immunocompetent cells. The enteric glial cells from the enteric nervous system (ENS) express the lipocalin-type-prostaglandin D synthase and secrete PGD2 and 15d-PGJ2. The protective role of the ENS in the homeostatic control of the epithelial intestinal barrier and its involvement in the pathogenesis of IBD have already been demonstrated. Thus, these lipid mediators seem to be new actors of the neuro-glio-epithelial unit and could play a crucial role maintaining gut barrier integrity.</description><subject>Animals</subject><subject>Epithelial Cells</subject><subject>Epithelial Cells - physiology</subject><subject>Homeostasis</subject><subject>Homeostasis - physiology</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases</subject><subject>Inflammatory Bowel Diseases - etiology</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>Intestinal Mucosa</subject><subject>Intestinal Mucosa - physiology</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Lipids - pharmacology</subject><subject>Paracrine Communication</subject><subject>Prostaglandin D2</subject><subject>Prostaglandin D2 - physiology</subject><issn>0767-0974</issn><issn>1958-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFPwzAMhSMEYmPwBzigHuFQZidN0hzRBgxpEpfdq7RJaVDajqZF4t-TaYOL_WR9fno2IbcIjwgcl601oXJLCsgZggDMzsgcFc9TznI8J3OQQqagZDYjVyF8AlDklF2SGRVRoOBzslpP2idD721S90OyH_ow6g-vO-O6ZE2TWF032jC6LnJ278bGehdl07f2wAYXrslFrX2wN6e-ILuX591qk27fX99WT9u0UcDTjIGkIETJaoW1qEqTaRA5QkaltMqamN_QWhptdC6ZLVXNKgS0wIXCXLEFeTjaNtoX-8G1evgpeu2KzdO2OMwgi3tUyW-M7P2RjQd9TTF-0bpQWR8Ps_0UChSKo5S5PNjendCpjB_9d_77EfsFXgZoHw</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Le Loupp, Anne-Gaelle</creator><creator>Bach-Ngohou, Kalyane</creator><creator>Bettan, Armel</creator><creator>Denis, Marc</creator><creator>Masson, Damien</creator><general>EDP Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>201506</creationdate><title>Dual role for prostaglandin D2 in intestinal epithelial homeostasis</title><author>Le Loupp, Anne-Gaelle ; Bach-Ngohou, Kalyane ; Bettan, Armel ; Denis, Marc ; Masson, Damien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h905-43072066b3f91f6cbd4a068104277e9ed014d2f7dada873eb9f3c101e05691893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; fre</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Epithelial Cells</topic><topic>Epithelial Cells - physiology</topic><topic>Homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases</topic><topic>Inflammatory Bowel Diseases - etiology</topic><topic>Inflammatory Bowel Diseases - pathology</topic><topic>Intestinal Mucosa</topic><topic>Intestinal Mucosa - physiology</topic><topic>Life Sciences</topic><topic>Lipids</topic><topic>Lipids - pharmacology</topic><topic>Paracrine Communication</topic><topic>Prostaglandin D2</topic><topic>Prostaglandin D2 - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Loupp, Anne-Gaelle</creatorcontrib><creatorcontrib>Bach-Ngohou, Kalyane</creatorcontrib><creatorcontrib>Bettan, Armel</creatorcontrib><creatorcontrib>Denis, Marc</creatorcontrib><creatorcontrib>Masson, Damien</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>M.S. 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Several results highlight the duality of PGD2 as an anti- or pro-inflammatory mediator. This duality seems to be related to a differential expression of its receptors by intestinal epithelial cells and the surrounding immunocompetent cells. The enteric glial cells from the enteric nervous system (ENS) express the lipocalin-type-prostaglandin D synthase and secrete PGD2 and 15d-PGJ2. The protective role of the ENS in the homeostatic control of the epithelial intestinal barrier and its involvement in the pathogenesis of IBD have already been demonstrated. Thus, these lipid mediators seem to be new actors of the neuro-glio-epithelial unit and could play a crucial role maintaining gut barrier integrity.</abstract><cop>France</cop><pub>EDP Sciences</pub><pmid>26152165</pmid><doi>10.1051/medsci/20153106014</doi><tpages>5</tpages></addata></record> |
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| ispartof | M.S. Médecine sciences, 2015-06, Vol.31 (6-7), p.617-621 |
| issn | 0767-0974 1958-5381 |
| language | eng ; fre |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Epithelial Cells Epithelial Cells - physiology Homeostasis Homeostasis - physiology Human health and pathology Humans Inflammatory Bowel Diseases Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - pathology Intestinal Mucosa Intestinal Mucosa - physiology Life Sciences Lipids Lipids - pharmacology Paracrine Communication Prostaglandin D2 Prostaglandin D2 - physiology |
| title | Dual role for prostaglandin D2 in intestinal epithelial homeostasis |
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