The Neuroprotective Effect of the X Protein of Orthobornavirus Bornaense Type 1 in Amyotrophic Lateral Sclerosis

In amyotrophic lateral sclerosis (ALS), early mitochondrial dysfunction may contribute to progressive motor neuron loss. Remarkably, the ectopic expression of the Orthobornavirus bornaense type 1 (BoDV-1) X protein in mitochondria blocks apoptosis and protects neurons from degeneration. Therefore, t...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.25 (23), p.12789
Hauptverfasser:	Tournezy, Jeflie, Léger, Claire, Klonjkowski, Bernard, Gonzalez-Dunia, Daniel, Szelechowski, Marion, Garenne, André, Mathis, Stéphane, Chevallier, Stéphanie, Le Masson, Gwendal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Adenosine Triphosphate - metabolism Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Analysis Animals Apoptosis Asymptomatic Cell death Development and progression Disease Models, Animal Health aspects Humans Life Sciences Medical research Medicine, Experimental Mice Mice, Transgenic Motor Neurons - metabolism Motor Neurons - pathology Muscle proteins Mutation Neurodegeneration Neurons Neuroprotective Agents - pharmacology Peptides Phosphorylation Proteins Spinal cord Vectors (Biology) Viral Proteins - genetics Viral Proteins - metabolism
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