Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery
Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence...
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| Veröffentlicht in: | Brain imaging and behavior 2014-09, Vol.8 (3), p.420-434 |
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| creator | Weaver, Starla M. Portelli, Jaclyn N. Chau, Aileen Cristofori, Irene Moretti, Laura Grafman, Jordan |
| description | Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation. |
| doi_str_mv | 10.1007/s11682-012-9197-9 |
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Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-012-9197-9</identifier><identifier>PMID: 22878895</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Brain - physiopathology ; Brain Injuries - genetics ; Brain Injuries - physiopathology ; Brain Injuries - psychology ; Brain Injuries - rehabilitation ; Brain research ; Cognitive ability ; Cognitive science ; Executive function ; Genetic Predisposition to Disease ; Humans ; Medical imaging ; Neuroimaging ; Neuroimaging and Rehabilitation SPECIAL ISSUE ; Neuropsychology ; Neuroradiology ; Neurosciences ; Patients ; Polymorphism, Genetic ; Psychiatry ; Recovery of Function - genetics ; Rehabilitation ; Traumatic brain injury</subject><ispartof>Brain imaging and behavior, 2014-09, Vol.8 (3), p.420-434</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>Springer Science+Business Media New York 2014</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-4b8a540db20d01282d5d037e44252c8cbd7ed1d4cdd09df1db1990893ace1e493</citedby><cites>FETCH-LOGICAL-c509t-4b8a540db20d01282d5d037e44252c8cbd7ed1d4cdd09df1db1990893ace1e493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-012-9197-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-012-9197-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22878895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04856875$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Weaver, Starla M.</creatorcontrib><creatorcontrib>Portelli, Jaclyn N.</creatorcontrib><creatorcontrib>Chau, Aileen</creatorcontrib><creatorcontrib>Cristofori, Irene</creatorcontrib><creatorcontrib>Moretti, Laura</creatorcontrib><creatorcontrib>Grafman, Jordan</creatorcontrib><title>Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><addtitle>Brain Imaging Behav</addtitle><description>Recovery after Traumatic Brain Injury (TBI) is variable, even for patients with similar severity of brain injury. Recent research has highlighted the contribution that genetic predisposition plays in determining TBI outcome. This review considers the potential for genetic polymorphisms to influence recovery of cognitive and social processes following TBI. Limitations and considerations that researchers should make when assessing the potential impact of polymorphisms on TBI outcome are also discussed. Understanding the genetic factors that support neuroplasticity will contribute to an understanding of the variation in outcome following injury and help to identify potential targets for rehabilitation.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - physiopathology</subject><subject>Brain Injuries - genetics</subject><subject>Brain Injuries - physiopathology</subject><subject>Brain Injuries - psychology</subject><subject>Brain Injuries - rehabilitation</subject><subject>Brain research</subject><subject>Cognitive ability</subject><subject>Cognitive science</subject><subject>Executive function</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Neuroimaging</subject><subject>Neuroimaging and Rehabilitation SPECIAL ISSUE</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Patients</subject><subject>Polymorphism, Genetic</subject><subject>Psychiatry</subject><subject>Recovery of Function - 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| subjects | Biomedical and Life Sciences Biomedicine Brain - physiopathology Brain Injuries - genetics Brain Injuries - physiopathology Brain Injuries - psychology Brain Injuries - rehabilitation Brain research Cognitive ability Cognitive science Executive function Genetic Predisposition to Disease Humans Medical imaging Neuroimaging Neuroimaging and Rehabilitation SPECIAL ISSUE Neuropsychology Neuroradiology Neurosciences Patients Polymorphism, Genetic Psychiatry Recovery of Function - genetics Rehabilitation Traumatic brain injury |
| title | Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery |
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