GlyR α3: An essential target for spinal PGE2-Mediated inflammatory pain sensitization

Prostaglandin E2 (PGE2) is a crucial mediator of inflammatory pain sensitization. Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization. We show that GlyR α3 is distinctly expre...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-05, Vol.304 (5672), p.884-887
Hauptverfasser:	HARVEY, Robert J, DEPNER, Ulrike B, ZIMMER, Andreas, POISBEAU, Pierrick, WELZL, Hans, WOLFER, David P, BETZ, Heinrich, ZEILHOFER, Hanns Ulrich, MÜLLER, Ulrike, WÄSSLE, Heinz, AHMADI, Seifollah, HEINDL, Cornelia, REINOLD, Helko, SMART, Trevor G, HARVEY, Kirsten, SCHÜTZ, Burkhard, ABO-SALEM, Osama M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Life Sciences Neurons and Cognition Vertebrates: nervous system and sense organs
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