Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression
Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB tran...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2004-10, Vol.306 (5696), p.704-708 |
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| creator | Nelson, D. E. Ihekwaba, A. E. C. Elliott, M. Johnson, J. R. Gibney, C. A. Foreman, B. E. Nelson, G. See, V. Horton, C. A. Spiller, D. G. Edwards, S. W. McDowell, H. P. Unitt, J. F. Sullivan, E. Grimley, R. Benson, N. Broomhead, D. Kell, D. B. White, M. R. H. |
| description | Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB translocation. Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-κB signaling may thus depend on number, period, and amplitude of oscillations. |
| doi_str_mv | 10.1126/science.1099962 |
| format | Article |
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E. ; Ihekwaba, A. E. C. ; Elliott, M. ; Johnson, J. R. ; Gibney, C. A. ; Foreman, B. E. ; Nelson, G. ; See, V. ; Horton, C. A. ; Spiller, D. G. ; Edwards, S. W. ; McDowell, H. P. ; Unitt, J. F. ; Sullivan, E. ; Grimley, R. ; Benson, N. ; Broomhead, D. ; Kell, D. B. ; White, M. R. H.</creator><creatorcontrib>Nelson, D. E. ; Ihekwaba, A. E. C. ; Elliott, M. ; Johnson, J. R. ; Gibney, C. A. ; Foreman, B. E. ; Nelson, G. ; See, V. ; Horton, C. A. ; Spiller, D. G. ; Edwards, S. W. ; McDowell, H. P. ; Unitt, J. F. ; Sullivan, E. ; Grimley, R. ; Benson, N. ; Broomhead, D. ; Kell, D. B. ; White, M. R. H.</creatorcontrib><description>Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB translocation. Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-κB signaling may thus depend on number, period, and amplitude of oscillations.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1099962</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Biological and medical sciences ; Cell lines ; Cell physiology ; Cells ; Computational modeling ; Data lines ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genetic regulation ; HeLa cells ; Imaging ; Life Sciences ; Medical research ; Molecular and cellular biology ; Oscillation ; Physiological aspects ; Signal transduction ; T lymphocytes</subject><ispartof>Science (American Association for the Advancement of Science), 2004-10, Vol.306 (5696), p.704-708</ispartof><rights>Copyright 2004 American Association for the Advancement of Science</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 American Association for the Advancement of Science</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-d057fad38354cd8d7fbc1ef6080faacd2b90891348ba3511daac0c55b7e4a4ac3</citedby><cites>FETCH-LOGICAL-c568t-d057fad38354cd8d7fbc1ef6080faacd2b90891348ba3511daac0c55b7e4a4ac3</cites><orcidid>0000-0001-6384-8381</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3839391$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3839391$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16219485$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04850820$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Nelson, D. E.</creatorcontrib><creatorcontrib>Ihekwaba, A. E. C.</creatorcontrib><creatorcontrib>Elliott, M.</creatorcontrib><creatorcontrib>Johnson, J. R.</creatorcontrib><creatorcontrib>Gibney, C. A.</creatorcontrib><creatorcontrib>Foreman, B. E.</creatorcontrib><creatorcontrib>Nelson, G.</creatorcontrib><creatorcontrib>See, V.</creatorcontrib><creatorcontrib>Horton, C. A.</creatorcontrib><creatorcontrib>Spiller, D. G.</creatorcontrib><creatorcontrib>Edwards, S. W.</creatorcontrib><creatorcontrib>McDowell, H. P.</creatorcontrib><creatorcontrib>Unitt, J. F.</creatorcontrib><creatorcontrib>Sullivan, E.</creatorcontrib><creatorcontrib>Grimley, R.</creatorcontrib><creatorcontrib>Benson, N.</creatorcontrib><creatorcontrib>Broomhead, D.</creatorcontrib><creatorcontrib>Kell, D. B.</creatorcontrib><creatorcontrib>White, M. R. H.</creatorcontrib><title>Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression</title><title>Science (American Association for the Advancement of Science)</title><description>Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB translocation. Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-κB signaling may thus depend on number, period, and amplitude of oscillations.</description><subject>Biological and medical sciences</subject><subject>Cell lines</subject><subject>Cell physiology</subject><subject>Cells</subject><subject>Computational modeling</subject><subject>Data lines</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genetic regulation</subject><subject>HeLa cells</subject><subject>Imaging</subject><subject>Life Sciences</subject><subject>Medical research</subject><subject>Molecular and cellular biology</subject><subject>Oscillation</subject><subject>Physiological aspects</subject><subject>Signal transduction</subject><subject>T lymphocytes</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkrFu2zAQhomiBeo6nbt00NICGeQcRVGmRsdN7ABGPKTtSpwpUmEgky4pB8mr9SH6TGUgI0GADAYHEnffT-D--wn5QmFCaVGdRWW1U3pCoa7rqnhHRunF87oA9p6MAFiVC5jyj-RTjHcAqVezEVmuk67rsLfexcy67Poy__f3PLuxrcPOujabe9cH32X9rc5-PDrcWhUzb7KFdjq7eNgFHWMSn5APBruoPx_uMfl1efFzvsxX68XVfLbKFa9EnzfApwYbJhgvVSOaqdkoqk0FAgyiaopNDaKmrBQbZJzSJhVBcb6Z6hJLVGxMTod_b7GTu2C3GB6lRyuXs5V8qkEpOIgC7mlivw_sLvg_ex17ubVR6TSu034fJRXAGOMsgfkAtthpaZ3xfUDVpgkDdt5pY1N5RouSsgqSb2MyeYNPp9HJnjcFp68Eien1Q9_iPkZ5dXN9PLv-fTx7vjiaFYvVa_ZsYFXwMQZtnq2mIJ_iJg9xk4e4JcW3g9cYFXYmoFM2vsiqgtZpM4n7OnB3sffhuZ8CUbO09_9sLNsT</recordid><startdate>20041022</startdate><enddate>20041022</enddate><creator>Nelson, D. 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H.</creator><general>American Association for the Advancement of Science</general><general>American Association for the Advancement of Science (AAAS)</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7TM</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6384-8381</orcidid></search><sort><creationdate>20041022</creationdate><title>Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression</title><author>Nelson, D. E. ; Ihekwaba, A. E. C. ; Elliott, M. ; Johnson, J. R. ; Gibney, C. A. ; Foreman, B. E. ; Nelson, G. ; See, V. ; Horton, C. A. ; Spiller, D. G. ; Edwards, S. W. ; McDowell, H. P. ; Unitt, J. F. ; Sullivan, E. ; Grimley, R. ; Benson, N. ; Broomhead, D. ; Kell, D. B. ; White, M. R. 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R. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><date>2004-10-22</date><risdate>2004</risdate><volume>306</volume><issue>5696</issue><spage>704</spage><epage>708</epage><pages>704-708</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Signaling by the transcription factor nuclear factor kappa B (NF-κB) involves its release from inhibitor kappa B (IκB) in the cytosol, followed by translocation into the nucleus. NF-κB regulation of IκBα transcription represents a delayed negative feedback loop that drives oscillations in NF-κB translocation. Single-cell time-lapse imaging and computational modeling of NF-κB (RelA) localization showed asynchronous oscillations following cell stimulation that decreased in frequency with increased IκBα transcription. Transcription of target genes depended on oscillation persistence, involving cycles of RelA phosphorylation and dephosphorylation. The functional consequences of NF-κB signaling may thus depend on number, period, and amplitude of oscillations.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><doi>10.1126/science.1099962</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-6384-8381</orcidid></addata></record> |
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| subjects | Biological and medical sciences Cell lines Cell physiology Cells Computational modeling Data lines Fundamental and applied biological sciences. Psychology Gene expression Genetic regulation HeLa cells Imaging Life Sciences Medical research Molecular and cellular biology Oscillation Physiological aspects Signal transduction T lymphocytes |
| title | Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression |
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