Innate predisposition to immune escape in follicular lymphoma cells

Innate predisposition to immune escape in follicular lymphoma cells

Tumor-intrinsic immuno-resistance is a prerequisite for emergence of follicular lymphomas. Here we show that in vitro, such cells are more resistant to immune cytolysis when grown as follicle-mimicking tridimensional aggregates than when grown as cell suspensions. So in patients, this innate adaptat...

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Veröffentlicht in:Oncoimmunology 2012-07, Vol.1 (4), p.555-556
Hauptverfasser: Gravelle, Pauline, Jean, Christine, Valleron, Wilfried, Laurent, Guy, Fournié, Jean-Jacques
Format: Artikel
Sprache:eng
Schlagworte:
aggregates
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cellular Biology
Cycle
immune escape models
Landes
Life Sciences
lymphoma
Organogenesis
Proteins
transcriptome
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container_end_page 556
container_issue 4
container_start_page 555
container_title Oncoimmunology
container_volume 1
creator Gravelle, Pauline
Jean, Christine
Valleron, Wilfried
Laurent, Guy
Fournié, Jean-Jacques
description Tumor-intrinsic immuno-resistance is a prerequisite for emergence of follicular lymphomas. Here we show that in vitro, such cells are more resistant to immune cytolysis when grown as follicle-mimicking tridimensional aggregates than when grown as cell suspensions. So in patients, this innate adaptation to tumor immunity might precede its selective pressure.
doi_str_mv 10.4161/onci.19365
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subjects aggregates
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cellular Biology
Cycle
immune escape models
Landes
Life Sciences
lymphoma
Organogenesis
Proteins
transcriptome
title Innate predisposition to immune escape in follicular lymphoma cells
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