Innate predisposition to immune escape in follicular lymphoma cells

Innate predisposition to immune escape in follicular lymphoma cells

Tumor-intrinsic immuno-resistance is a prerequisite for emergence of follicular lymphomas. Here we show that in vitro, such cells are more resistant to immune cytolysis when grown as follicle-mimicking tridimensional aggregates than when grown as cell suspensions. So in patients, this innate adaptat...

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Veröffentlicht in:Oncoimmunology 2012-07, Vol.1 (4), p.555-556
Hauptverfasser: Gravelle, Pauline, Jean, Christine, Valleron, Wilfried, Laurent, Guy, Fournié, Jean-Jacques
Format: Artikel
Sprache:eng
Schlagworte:
aggregates
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cellular Biology
Cycle
immune escape models
Landes
Life Sciences
lymphoma
Organogenesis
Proteins
transcriptome
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Beschreibung
Zusammenfassung:Tumor-intrinsic immuno-resistance is a prerequisite for emergence of follicular lymphomas. Here we show that in vitro, such cells are more resistant to immune cytolysis when grown as follicle-mimicking tridimensional aggregates than when grown as cell suspensions. So in patients, this innate adaptation to tumor immunity might precede its selective pressure.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.19365