Changes in cardiac function following a speed ascent to the top of Europe at 4808 m
Purpose Both prolonged exercise and acute high-altitude exposure are known to induce cardiac changes. We sought to describe the cardiac responses to speed climbing at high-altitude, including left ventricular (LV) performance assessment using the myocardial work index (MWI), a new index derived from...
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| Veröffentlicht in: | European journal of applied physiology 2022-04, Vol.122 (4), p.889-902 |
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| container_title | European journal of applied physiology |
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| creator | Champigneulle, Benoit Doutreleau, Stéphane Baillieul, Sébastien Brugniaux, Julien Vincent Robach, Paul Bouzat, Pierre Verges, Samuel |
| description | Purpose
Both prolonged exercise and acute high-altitude exposure are known to induce cardiac changes. We sought to describe the cardiac responses to speed climbing at high-altitude, including left ventricular (LV) performance assessment using the myocardial work index (MWI), a new index derived from 2D speckle tracking echocardiography (STE).
Methods
Eleven elite alpinists (9 males, age: 26 ± 4 years) were evaluated before and immediately after a speed ascent of the Mont-Blanc (4808 m) by echocardiography using conventional measurements as well as STE and MWI computation with derivate parameters as global work efficiency (GWE) or global wasted work (GWW).
Results
Athletes performed a long-duration (8 h 58 min ± 60 min) and intense (78 ± 4% of maximal heart rate) ascent under gradual hypoxic conditions (minimal SpO
2
at 4808 m: 71 ± 4%). Hypoxic exercise-induced cardiac fatigue was observed post-ascent with a change in right ventricular (RV) and LV systolic function (RV fractional area change: – 20 ± 23%,
p
= 0.01; LV global longitudinal strain change: – 8 ± 9%,
p
= 0.02), as well as LV geometry and RV–LV interaction alterations with emergence of a D-shape septum in 5/11 (46%) participants associated with RV pressure overload (mean pulmonary arterial pressure change: + 55 ± 20%,
p
|
| doi_str_mv | 10.1007/s00421-022-04895-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_04820987v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2640583988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-c8be477e3e39a4b1a9a974bff9a7f1bbfce1731a7a353b7e31864ad36cd435053</originalsourceid><addsrcrecordid>eNp9kc9u1DAQhy0EoqXwAhyQJS5wSBn_SWwfq1WhSCv1Us7WxLG7qbJxsBMq3oZn4cnwNmWROPQ0lv35Nx5_hLxlcM4A1KcMIDmrgPMKpDZ11Twjp0wKUzWCq-fHNTMn5FXOdwCgOdMvyYmoGQjd8FNys9nheOsz7UfqMHU9OhqW0c19HGmIwxDv-_GWIs2T9x3F7Pw40znSeedLmWgM9HJJcfIUZyo16N-_9q_Ji4BD9m8e6xn59vnyZnNVba-_fN1cbCsnwcyV062XSnnhhUHZMjRolGxDMKgCa9vgPFOCoUJRi7ZwTDcSO9G4TooaanFGPq65OxzslPo9pp82Ym-vLrb2sFe-hYPR6gcr7IeVnVL8vvg8231fhhkGHH1csuUNl00tQTQFff8feheXNJZJCiWh1sJoXSi-Ui7FnJMPxxcwsAc_dvVjix_74Mceot89Ri_t3nfHK3-FFECsQC5HRUz61_uJ2D9MfZjW</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2640583988</pqid></control><display><type>article</type><title>Changes in cardiac function following a speed ascent to the top of Europe at 4808 m</title><source>SpringerLink Journals - AutoHoldings</source><creator>Champigneulle, Benoit ; Doutreleau, Stéphane ; Baillieul, Sébastien ; Brugniaux, Julien Vincent ; Robach, Paul ; Bouzat, Pierre ; Verges, Samuel</creator><creatorcontrib>Champigneulle, Benoit ; Doutreleau, Stéphane ; Baillieul, Sébastien ; Brugniaux, Julien Vincent ; Robach, Paul ; Bouzat, Pierre ; Verges, Samuel</creatorcontrib><description>Purpose
Both prolonged exercise and acute high-altitude exposure are known to induce cardiac changes. We sought to describe the cardiac responses to speed climbing at high-altitude, including left ventricular (LV) performance assessment using the myocardial work index (MWI), a new index derived from 2D speckle tracking echocardiography (STE).
Methods
Eleven elite alpinists (9 males, age: 26 ± 4 years) were evaluated before and immediately after a speed ascent of the Mont-Blanc (4808 m) by echocardiography using conventional measurements as well as STE and MWI computation with derivate parameters as global work efficiency (GWE) or global wasted work (GWW).
Results
Athletes performed a long-duration (8 h 58 min ± 60 min) and intense (78 ± 4% of maximal heart rate) ascent under gradual hypoxic conditions (minimal SpO
2
at 4808 m: 71 ± 4%). Hypoxic exercise-induced cardiac fatigue was observed post-ascent with a change in right ventricular (RV) and LV systolic function (RV fractional area change: – 20 ± 23%,
p
= 0.01; LV global longitudinal strain change: – 8 ± 9%,
p
= 0.02), as well as LV geometry and RV–LV interaction alterations with emergence of a D-shape septum in 5/11 (46%) participants associated with RV pressure overload (mean pulmonary arterial pressure change: + 55 ± 20%,
p
< 0.001). Both MWI and GWE were reduced post-ascent (– 21 ± 16%,
p
= 0.004 and – 4 ± 4%,
p
= 0.007, respectively). Relative decrease in MWI and GWE were inversely correlated with increase in GWW (
r
= – 0.86,
p
= 0.003 and
r
= -0.97,
p
< 0.001, respectively).
Conclusions
Prolonged high-altitude speed climbing in elite climbers is associated with RV and LV function changes with a major interaction alteration. MWI, assessing the myocardial performance, could be a new tool for evaluating LV exercise-induced cardiac fatigue.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-022-04895-6</identifier><identifier>PMID: 35103862</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Altitude ; Assessment of cardiovascular function during human activities ; Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Echocardiography ; Fatigue ; Heart rate ; High-altitude environments ; Human health and pathology ; Human Physiology ; Hypoxia ; Life Sciences ; Occupational Medicine/Industrial Medicine ; Original Article ; Physical training ; Septum ; Sports Medicine ; Ventricle</subject><ispartof>European journal of applied physiology, 2022-04, Vol.122 (4), p.889-902</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-c8be477e3e39a4b1a9a974bff9a7f1bbfce1731a7a353b7e31864ad36cd435053</citedby><cites>FETCH-LOGICAL-c409t-c8be477e3e39a4b1a9a974bff9a7f1bbfce1731a7a353b7e31864ad36cd435053</cites><orcidid>0000-0003-0922-5102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-022-04895-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-022-04895-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35103862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04820987$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Champigneulle, Benoit</creatorcontrib><creatorcontrib>Doutreleau, Stéphane</creatorcontrib><creatorcontrib>Baillieul, Sébastien</creatorcontrib><creatorcontrib>Brugniaux, Julien Vincent</creatorcontrib><creatorcontrib>Robach, Paul</creatorcontrib><creatorcontrib>Bouzat, Pierre</creatorcontrib><creatorcontrib>Verges, Samuel</creatorcontrib><title>Changes in cardiac function following a speed ascent to the top of Europe at 4808 m</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
Both prolonged exercise and acute high-altitude exposure are known to induce cardiac changes. We sought to describe the cardiac responses to speed climbing at high-altitude, including left ventricular (LV) performance assessment using the myocardial work index (MWI), a new index derived from 2D speckle tracking echocardiography (STE).
Methods
Eleven elite alpinists (9 males, age: 26 ± 4 years) were evaluated before and immediately after a speed ascent of the Mont-Blanc (4808 m) by echocardiography using conventional measurements as well as STE and MWI computation with derivate parameters as global work efficiency (GWE) or global wasted work (GWW).
Results
Athletes performed a long-duration (8 h 58 min ± 60 min) and intense (78 ± 4% of maximal heart rate) ascent under gradual hypoxic conditions (minimal SpO
2
at 4808 m: 71 ± 4%). Hypoxic exercise-induced cardiac fatigue was observed post-ascent with a change in right ventricular (RV) and LV systolic function (RV fractional area change: – 20 ± 23%,
p
= 0.01; LV global longitudinal strain change: – 8 ± 9%,
p
= 0.02), as well as LV geometry and RV–LV interaction alterations with emergence of a D-shape septum in 5/11 (46%) participants associated with RV pressure overload (mean pulmonary arterial pressure change: + 55 ± 20%,
p
< 0.001). Both MWI and GWE were reduced post-ascent (– 21 ± 16%,
p
= 0.004 and – 4 ± 4%,
p
= 0.007, respectively). Relative decrease in MWI and GWE were inversely correlated with increase in GWW (
r
= – 0.86,
p
= 0.003 and
r
= -0.97,
p
< 0.001, respectively).
Conclusions
Prolonged high-altitude speed climbing in elite climbers is associated with RV and LV function changes with a major interaction alteration. MWI, assessing the myocardial performance, could be a new tool for evaluating LV exercise-induced cardiac fatigue.</description><subject>Altitude</subject><subject>Assessment of cardiovascular function during human activities</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Echocardiography</subject><subject>Fatigue</subject><subject>Heart rate</subject><subject>High-altitude environments</subject><subject>Human health and pathology</subject><subject>Human Physiology</subject><subject>Hypoxia</subject><subject>Life Sciences</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Physical training</subject><subject>Septum</subject><subject>Sports Medicine</subject><subject>Ventricle</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9u1DAQhy0EoqXwAhyQJS5wSBn_SWwfq1WhSCv1Us7WxLG7qbJxsBMq3oZn4cnwNmWROPQ0lv35Nx5_hLxlcM4A1KcMIDmrgPMKpDZ11Twjp0wKUzWCq-fHNTMn5FXOdwCgOdMvyYmoGQjd8FNys9nheOsz7UfqMHU9OhqW0c19HGmIwxDv-_GWIs2T9x3F7Pw40znSeedLmWgM9HJJcfIUZyo16N-_9q_Ji4BD9m8e6xn59vnyZnNVba-_fN1cbCsnwcyV062XSnnhhUHZMjRolGxDMKgCa9vgPFOCoUJRi7ZwTDcSO9G4TooaanFGPq65OxzslPo9pp82Ym-vLrb2sFe-hYPR6gcr7IeVnVL8vvg8231fhhkGHH1csuUNl00tQTQFff8feheXNJZJCiWh1sJoXSi-Ui7FnJMPxxcwsAc_dvVjix_74Mceot89Ri_t3nfHK3-FFECsQC5HRUz61_uJ2D9MfZjW</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Champigneulle, Benoit</creator><creator>Doutreleau, Stéphane</creator><creator>Baillieul, Sébastien</creator><creator>Brugniaux, Julien Vincent</creator><creator>Robach, Paul</creator><creator>Bouzat, Pierre</creator><creator>Verges, Samuel</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-0922-5102</orcidid></search><sort><creationdate>20220401</creationdate><title>Changes in cardiac function following a speed ascent to the top of Europe at 4808 m</title><author>Champigneulle, Benoit ; Doutreleau, Stéphane ; Baillieul, Sébastien ; Brugniaux, Julien Vincent ; Robach, Paul ; Bouzat, Pierre ; Verges, Samuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-c8be477e3e39a4b1a9a974bff9a7f1bbfce1731a7a353b7e31864ad36cd435053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Altitude</topic><topic>Assessment of cardiovascular function during human activities</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood pressure</topic><topic>Echocardiography</topic><topic>Fatigue</topic><topic>Heart rate</topic><topic>High-altitude environments</topic><topic>Human health and pathology</topic><topic>Human Physiology</topic><topic>Hypoxia</topic><topic>Life Sciences</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Physical training</topic><topic>Septum</topic><topic>Sports Medicine</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Champigneulle, Benoit</creatorcontrib><creatorcontrib>Doutreleau, Stéphane</creatorcontrib><creatorcontrib>Baillieul, Sébastien</creatorcontrib><creatorcontrib>Brugniaux, Julien Vincent</creatorcontrib><creatorcontrib>Robach, Paul</creatorcontrib><creatorcontrib>Bouzat, Pierre</creatorcontrib><creatorcontrib>Verges, Samuel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Champigneulle, Benoit</au><au>Doutreleau, Stéphane</au><au>Baillieul, Sébastien</au><au>Brugniaux, Julien Vincent</au><au>Robach, Paul</au><au>Bouzat, Pierre</au><au>Verges, Samuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in cardiac function following a speed ascent to the top of Europe at 4808 m</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>122</volume><issue>4</issue><spage>889</spage><epage>902</epage><pages>889-902</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
Both prolonged exercise and acute high-altitude exposure are known to induce cardiac changes. We sought to describe the cardiac responses to speed climbing at high-altitude, including left ventricular (LV) performance assessment using the myocardial work index (MWI), a new index derived from 2D speckle tracking echocardiography (STE).
Methods
Eleven elite alpinists (9 males, age: 26 ± 4 years) were evaluated before and immediately after a speed ascent of the Mont-Blanc (4808 m) by echocardiography using conventional measurements as well as STE and MWI computation with derivate parameters as global work efficiency (GWE) or global wasted work (GWW).
Results
Athletes performed a long-duration (8 h 58 min ± 60 min) and intense (78 ± 4% of maximal heart rate) ascent under gradual hypoxic conditions (minimal SpO
2
at 4808 m: 71 ± 4%). Hypoxic exercise-induced cardiac fatigue was observed post-ascent with a change in right ventricular (RV) and LV systolic function (RV fractional area change: – 20 ± 23%,
p
= 0.01; LV global longitudinal strain change: – 8 ± 9%,
p
= 0.02), as well as LV geometry and RV–LV interaction alterations with emergence of a D-shape septum in 5/11 (46%) participants associated with RV pressure overload (mean pulmonary arterial pressure change: + 55 ± 20%,
p
< 0.001). Both MWI and GWE were reduced post-ascent (– 21 ± 16%,
p
= 0.004 and – 4 ± 4%,
p
= 0.007, respectively). Relative decrease in MWI and GWE were inversely correlated with increase in GWW (
r
= – 0.86,
p
= 0.003 and
r
= -0.97,
p
< 0.001, respectively).
Conclusions
Prolonged high-altitude speed climbing in elite climbers is associated with RV and LV function changes with a major interaction alteration. MWI, assessing the myocardial performance, could be a new tool for evaluating LV exercise-induced cardiac fatigue.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35103862</pmid><doi>10.1007/s00421-022-04895-6</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0922-5102</orcidid></addata></record> |
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| ispartof | European journal of applied physiology, 2022-04, Vol.122 (4), p.889-902 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04820987v1 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Altitude Assessment of cardiovascular function during human activities Biomedical and Life Sciences Biomedicine Blood pressure Echocardiography Fatigue Heart rate High-altitude environments Human health and pathology Human Physiology Hypoxia Life Sciences Occupational Medicine/Industrial Medicine Original Article Physical training Septum Sports Medicine Ventricle |
| title | Changes in cardiac function following a speed ascent to the top of Europe at 4808 m |
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