Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles

Platelets play a crucial role in the maintenance of hemostasis, as well as in thrombosis. Upon activation, platelets release small membrane-bound microparticles (MPs) containing bioactive proteins and genetic materials from their parental cells that may be transferred to, and exert potent biological...

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Veröffentlicht in:	Blood 2013-07, Vol.122 (2), p.253-261
Hauptverfasser:	Laffont, Benoit, Corduan, Aurélie, Plé, Hélène, Duchez, Anne-Claire, Cloutier, Nathalie, Boilard, Eric, Provost, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Argonaute Proteins - genetics Argonaute Proteins - metabolism Biological Transport Blood Platelets - physiology Cell-Derived Microparticles - physiology Endothelial Cells - metabolism Gene Expression Regulation Human Umbilical Vein Endothelial Cells - metabolism Humans Life Sciences Macromolecular Substances - metabolism MicroRNAs - genetics MicroRNAs - metabolism Platelet Activation - physiology RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism
Online-Zugang:	Volltext
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