Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity

The benzoxaborinine scaffold, a homologue of benzoxaborole with an additional carbon atom in the boracycle, shows significant potential in developing new therapeutic agents. This study reports the synthesis, inhibition assays against four human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, and anti...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-10, Vol.67 (20), p.18221-18234
Hauptverfasser:	Giovannuzzi, Simone, Nikitjuka, Anna, Angeli, Andrea, Smietana, Michael, Massardi, Maria-Luisa, Turati, Marta, Ronca, Roberto, Bonardi, Alessandro, Nocentini, Alessio, Ferraroni, Marta, Supuran, Claudiu T., Winum, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Boron Compounds - chemical synthesis Boron Compounds - chemistry Boron Compounds - pharmacology Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic Anhydrases - metabolism Cell Line, Tumor Cell Proliferation - drug effects Chemical Sciences Crystallography, X-Ray Drug Screening Assays, Antitumor Humans Melanoma - drug therapy Melanoma - pathology Models, Molecular Structure-Activity Relationship
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