Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic MR Elastography
Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction-associated steatohepatitis. To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acous...
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| creator | Koch, Vitali Gotta, Jennifer Chernyak, Victoria Cengiz, Duygu Torgashov, Katerina Eichler, Katrin Vilgrain, Valérie Martin, Simon S Ziegengeist, Nicole S Konrad, Paul Booz, Christian Yel, Ibrahim D'Angelo, Tommaso Mahmoudi, Scherwin Scholtz, Jan-Erik Bernatz, Simon Alizadeh, Leona S Cimprich, Marina Solim, Levent A Thalhammer, Axel Gruber-Rouh, Tatjana Hammerstingl, Renate M Zeuzem, Stefan Finkelmeier, Fabian Pathil-Warth, Anita Onay, Melis Kinzler, Maximilian N Darwish, Omar Annio, Giacomo Taylor, Stuart A Wild, Peter Dahmer, Iulia Herrmann, Eva Almansour, Haidara Vogl, Thomas J Gruenewald, Leon D Sinkus, Ralph |
| description | Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction-associated steatohepatitis.
To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acoustic (AC) solution utilizing a 2D-MRE approach. Additionally, quality index markers (QIs) were proposed to identify image pixels with sufficient quality for reliably estimating tissue biomechanics.
Prospective.
One hundred seventy participants with suspected or confirmed liver disease (median age, 57 years [interquartile range (IQR), 46-65]; 66 females), and 11 healthy volunteers (median age, 31 years [IQR, 27-34]; 5 females).
Participants were scanned twice at 1.5 T and 60 Hz vibration frequency: first, using AC-MRE (2D-MRE, spin-echo EPI sequence, 11 seconds breath-hold), and second, using GT-MRE (2D- and 3D-MRE, gradient-echo sequence, 14 seconds breath-hold).
Image analysis was performed by four independent radiologists and one biomedical engineer. Additionally, superimposed analytic plane shear waves of known wavelength and attenuation at fixed shear modulus were used to propose pertinent QIs.
Spearman's correlation coefficient (r) was applied to assess the correlation between modalities. Interreader reproducibility was evaluated using Bland-Altman bias and reproducibility coefficients. P-values |
| doi_str_mv | 10.1002/jmri.29560 |
| format | Article |
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To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acoustic (AC) solution utilizing a 2D-MRE approach. Additionally, quality index markers (QIs) were proposed to identify image pixels with sufficient quality for reliably estimating tissue biomechanics.
Prospective.
One hundred seventy participants with suspected or confirmed liver disease (median age, 57 years [interquartile range (IQR), 46-65]; 66 females), and 11 healthy volunteers (median age, 31 years [IQR, 27-34]; 5 females).
Participants were scanned twice at 1.5 T and 60 Hz vibration frequency: first, using AC-MRE (2D-MRE, spin-echo EPI sequence, 11 seconds breath-hold), and second, using GT-MRE (2D- and 3D-MRE, gradient-echo sequence, 14 seconds breath-hold).
Image analysis was performed by four independent radiologists and one biomedical engineer. Additionally, superimposed analytic plane shear waves of known wavelength and attenuation at fixed shear modulus were used to propose pertinent QIs.
Spearman's correlation coefficient (r) was applied to assess the correlation between modalities. Interreader reproducibility was evaluated using Bland-Altman bias and reproducibility coefficients. P-values <0.05 were considered statistically significant.
Liver stiffness quantified via GT-2D/3D correlated well with AC-2D (r ≥ 0.89 [95% CI: 0.85-0.92]) and histopathological grading (r ≥ 0.84 [95% CI: 0.72-0.91]), demonstrating excellent agreement in Bland-Altman plots and between readers (κ ≥ 0.86 [95% CI: 0.81-0.91]). However, GT-2D showed a bias in overestimating stiffness compared to GT-3D. Proposed QIs enabled the identification of pixels deviating beyond 10% from true stiffness based on a combination of total wave amplitude, temporal sinusoidal nonlinearity, and wave signal-to-noise ratio for GT-3D.
GT-MRE represents an alternative to AC-MRE for noninvasive liver tissue characterization. Both GT-2D and 3D approaches correlated strongly with the established commercial approach, offering advanced capabilities in abdominal imaging compared to AC-MRE.
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To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acoustic (AC) solution utilizing a 2D-MRE approach. Additionally, quality index markers (QIs) were proposed to identify image pixels with sufficient quality for reliably estimating tissue biomechanics.
Prospective.
One hundred seventy participants with suspected or confirmed liver disease (median age, 57 years [interquartile range (IQR), 46-65]; 66 females), and 11 healthy volunteers (median age, 31 years [IQR, 27-34]; 5 females).
Participants were scanned twice at 1.5 T and 60 Hz vibration frequency: first, using AC-MRE (2D-MRE, spin-echo EPI sequence, 11 seconds breath-hold), and second, using GT-MRE (2D- and 3D-MRE, gradient-echo sequence, 14 seconds breath-hold).
Image analysis was performed by four independent radiologists and one biomedical engineer. Additionally, superimposed analytic plane shear waves of known wavelength and attenuation at fixed shear modulus were used to propose pertinent QIs.
Spearman's correlation coefficient (r) was applied to assess the correlation between modalities. Interreader reproducibility was evaluated using Bland-Altman bias and reproducibility coefficients. P-values <0.05 were considered statistically significant.
Liver stiffness quantified via GT-2D/3D correlated well with AC-2D (r ≥ 0.89 [95% CI: 0.85-0.92]) and histopathological grading (r ≥ 0.84 [95% CI: 0.72-0.91]), demonstrating excellent agreement in Bland-Altman plots and between readers (κ ≥ 0.86 [95% CI: 0.81-0.91]). However, GT-2D showed a bias in overestimating stiffness compared to GT-3D. Proposed QIs enabled the identification of pixels deviating beyond 10% from true stiffness based on a combination of total wave amplitude, temporal sinusoidal nonlinearity, and wave signal-to-noise ratio for GT-3D.
GT-MRE represents an alternative to AC-MRE for noninvasive liver tissue characterization. Both GT-2D and 3D approaches correlated strongly with the established commercial approach, offering advanced capabilities in abdominal imaging compared to AC-MRE.
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Gotta, Jennifer ; Chernyak, Victoria ; Cengiz, Duygu ; Torgashov, Katerina ; Eichler, Katrin ; Vilgrain, Valérie ; Martin, Simon S ; Ziegengeist, Nicole S ; Konrad, Paul ; Booz, Christian ; Yel, Ibrahim ; D'Angelo, Tommaso ; Mahmoudi, Scherwin ; Scholtz, Jan-Erik ; Bernatz, Simon ; Alizadeh, Leona S ; Cimprich, Marina ; Solim, Levent A ; Thalhammer, Axel ; Gruber-Rouh, Tatjana ; Hammerstingl, Renate M ; Zeuzem, Stefan ; Finkelmeier, Fabian ; Pathil-Warth, Anita ; Onay, Melis ; Kinzler, Maximilian N ; Darwish, Omar ; Annio, Giacomo ; Taylor, Stuart A ; Wild, Peter ; Dahmer, Iulia ; Herrmann, Eva ; Almansour, Haidara ; Vogl, Thomas J ; Gruenewald, Leon D ; Sinkus, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c246t-501c547d8f26536a580b9573373eda266a940b7628d13e37a4b5fadd04bf668a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koch, Vitali</creatorcontrib><creatorcontrib>Gotta, Jennifer</creatorcontrib><creatorcontrib>Chernyak, Victoria</creatorcontrib><creatorcontrib>Cengiz, Duygu</creatorcontrib><creatorcontrib>Torgashov, Katerina</creatorcontrib><creatorcontrib>Eichler, Katrin</creatorcontrib><creatorcontrib>Vilgrain, Valérie</creatorcontrib><creatorcontrib>Martin, Simon S</creatorcontrib><creatorcontrib>Ziegengeist, Nicole S</creatorcontrib><creatorcontrib>Konrad, Paul</creatorcontrib><creatorcontrib>Booz, Christian</creatorcontrib><creatorcontrib>Yel, Ibrahim</creatorcontrib><creatorcontrib>D'Angelo, Tommaso</creatorcontrib><creatorcontrib>Mahmoudi, Scherwin</creatorcontrib><creatorcontrib>Scholtz, Jan-Erik</creatorcontrib><creatorcontrib>Bernatz, Simon</creatorcontrib><creatorcontrib>Alizadeh, Leona S</creatorcontrib><creatorcontrib>Cimprich, Marina</creatorcontrib><creatorcontrib>Solim, Levent A</creatorcontrib><creatorcontrib>Thalhammer, Axel</creatorcontrib><creatorcontrib>Gruber-Rouh, Tatjana</creatorcontrib><creatorcontrib>Hammerstingl, Renate M</creatorcontrib><creatorcontrib>Zeuzem, Stefan</creatorcontrib><creatorcontrib>Finkelmeier, Fabian</creatorcontrib><creatorcontrib>Pathil-Warth, Anita</creatorcontrib><creatorcontrib>Onay, Melis</creatorcontrib><creatorcontrib>Kinzler, Maximilian N</creatorcontrib><creatorcontrib>Darwish, Omar</creatorcontrib><creatorcontrib>Annio, Giacomo</creatorcontrib><creatorcontrib>Taylor, Stuart A</creatorcontrib><creatorcontrib>Wild, Peter</creatorcontrib><creatorcontrib>Dahmer, Iulia</creatorcontrib><creatorcontrib>Herrmann, Eva</creatorcontrib><creatorcontrib>Almansour, Haidara</creatorcontrib><creatorcontrib>Vogl, Thomas J</creatorcontrib><creatorcontrib>Gruenewald, Leon D</creatorcontrib><creatorcontrib>Sinkus, Ralph</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koch, Vitali</au><au>Gotta, Jennifer</au><au>Chernyak, Victoria</au><au>Cengiz, Duygu</au><au>Torgashov, Katerina</au><au>Eichler, Katrin</au><au>Vilgrain, Valérie</au><au>Martin, Simon S</au><au>Ziegengeist, Nicole S</au><au>Konrad, Paul</au><au>Booz, Christian</au><au>Yel, Ibrahim</au><au>D'Angelo, Tommaso</au><au>Mahmoudi, Scherwin</au><au>Scholtz, Jan-Erik</au><au>Bernatz, Simon</au><au>Alizadeh, Leona S</au><au>Cimprich, Marina</au><au>Solim, Levent A</au><au>Thalhammer, Axel</au><au>Gruber-Rouh, Tatjana</au><au>Hammerstingl, Renate M</au><au>Zeuzem, Stefan</au><au>Finkelmeier, Fabian</au><au>Pathil-Warth, Anita</au><au>Onay, Melis</au><au>Kinzler, Maximilian N</au><au>Darwish, Omar</au><au>Annio, Giacomo</au><au>Taylor, Stuart A</au><au>Wild, Peter</au><au>Dahmer, Iulia</au><au>Herrmann, Eva</au><au>Almansour, Haidara</au><au>Vogl, Thomas J</au><au>Gruenewald, Leon D</au><au>Sinkus, Ralph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic MR Elastography</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2024-08-21</date><risdate>2024</risdate><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction-associated steatohepatitis.
To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acoustic (AC) solution utilizing a 2D-MRE approach. Additionally, quality index markers (QIs) were proposed to identify image pixels with sufficient quality for reliably estimating tissue biomechanics.
Prospective.
One hundred seventy participants with suspected or confirmed liver disease (median age, 57 years [interquartile range (IQR), 46-65]; 66 females), and 11 healthy volunteers (median age, 31 years [IQR, 27-34]; 5 females).
Participants were scanned twice at 1.5 T and 60 Hz vibration frequency: first, using AC-MRE (2D-MRE, spin-echo EPI sequence, 11 seconds breath-hold), and second, using GT-MRE (2D- and 3D-MRE, gradient-echo sequence, 14 seconds breath-hold).
Image analysis was performed by four independent radiologists and one biomedical engineer. Additionally, superimposed analytic plane shear waves of known wavelength and attenuation at fixed shear modulus were used to propose pertinent QIs.
Spearman's correlation coefficient (r) was applied to assess the correlation between modalities. Interreader reproducibility was evaluated using Bland-Altman bias and reproducibility coefficients. P-values <0.05 were considered statistically significant.
Liver stiffness quantified via GT-2D/3D correlated well with AC-2D (r ≥ 0.89 [95% CI: 0.85-0.92]) and histopathological grading (r ≥ 0.84 [95% CI: 0.72-0.91]), demonstrating excellent agreement in Bland-Altman plots and between readers (κ ≥ 0.86 [95% CI: 0.81-0.91]). However, GT-2D showed a bias in overestimating stiffness compared to GT-3D. Proposed QIs enabled the identification of pixels deviating beyond 10% from true stiffness based on a combination of total wave amplitude, temporal sinusoidal nonlinearity, and wave signal-to-noise ratio for GT-3D.
GT-MRE represents an alternative to AC-MRE for noninvasive liver tissue characterization. Both GT-2D and 3D approaches correlated strongly with the established commercial approach, offering advanced capabilities in abdominal imaging compared to AC-MRE.
1 TECHNICAL EFFICACY: Stage 2.</abstract><cop>United States</cop><pub>Wiley-Blackwell</pub><pmid>39165139</pmid><doi>10.1002/jmri.29560</doi><orcidid>https://orcid.org/0009-0001-2999-2758</orcidid><orcidid>https://orcid.org/0000-0003-0004-6378</orcidid><orcidid>https://orcid.org/0000-0001-6915-5906</orcidid><orcidid>https://orcid.org/0000-0002-5715-1403</orcidid><orcidid>https://orcid.org/0000-0002-6093-1654</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_04795124v1 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Life Sciences |
| title | Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic MR Elastography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T20%3A30%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomechanical%20Assessment%20of%20Liver%20Integrity:%20Prospective%20Evaluation%20of%20Mechanical%20Versus%20Acoustic%20MR%20Elastography&rft.jtitle=Journal%20of%20magnetic%20resonance%20imaging&rft.au=Koch,%20Vitali&rft.date=2024-08-21&rft.issn=1053-1807&rft.eissn=1522-2586&rft_id=info:doi/10.1002/jmri.29560&rft_dat=%3Cproquest_hal_p%3E3095172806%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3095172806&rft_id=info:pmid/39165139&rfr_iscdi=true |