PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

Adult and child B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) differ in terms of incidence and prognosis. These disparities are mainly due to the molecular abnormalities associated with these two clinical entities. A genome-wide analysis using oligo SNP arrays recently demonstrated that P...

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Veröffentlicht in:	Leukemia 2009-11, Vol.23 (11), p.1989-1998
Hauptverfasser:	Familiades, J, Bousquet, M, Lafage-Pochitaloff, M, Béné, M-C, Beldjord, K, De Vos, J, Dastugue, N, Coyaud, E, Struski, S, Quelen, C, Prade-Houdellier, N, Dobbelstein, S, Cayuela, J-M, Soulier, J, Grardel, N, Preudhomme, C, Cavé, H, Blanchet, O, Lhéritier, V, Delannoy, A, Chalandon, Y, Ifrah, N, Pigneux, A, Brousset, P, Macintyre, E A, Huguet, F, Dombret, H, Broccardo, C, Delabesse, É
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acute lymphoblastic leukemia Acute lymphocytic leukemia Adolescent Adult Antineoplastic Agents Antineoplastic Agents - therapeutic use Basic Helix-Loop-Helix Transcription Factors Basic Helix-Loop-Helix Transcription Factors - genetics BCR-ABL protein Benzamides Biological and medical sciences Cancer Cancer Research Children Clinical Trials, Phase II as Topic Critical Care Medicine DNA-Binding Proteins DNA-Binding Proteins - genetics Fusion protein Fusion Proteins, bcr-abl Fusion Proteins, bcr-abl - genetics Gene deletion Gene Dosage Gene mutations Gene Rearrangement, T-Lymphocyte Gene Rearrangement, T-Lymphocyte - genetics Genes Genetic aspects Genomes Genomics Haploinsufficiency Haplotypes Health aspects Hematologic and hematopoietic diseases Hematology Humans Imatinib Mesylate Immunoglobulin Heavy Chains Immunoglobulin Heavy Chains - genetics Immunophenotyping Intensive Internal Medicine Kinases Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocytes Life Sciences Lymphatic leukemia Lymphocytes B Lymphoma Medical prognosis Medical research Medical sciences Medicine Medicine & Public Health Middle Aged Multicenter Studies as Topic Mutation Oncology original-article Pax5 protein PAX5 Transcription Factor PAX5 Transcription Factor - genetics Piperazines Piperazines - therapeutic use Point Mutation Pre-B-Cell Leukemia Transcription Factor 1 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Prognosis Prospective Studies Proto-Oncogene Proteins Proto-Oncogene Proteins - genetics Pyrimidines Pyrimidines - therapeutic use Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Translocation Young Adult
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