Cross-regulatory interactions among tracheal genes support a co-operative model for the induction of tracheal fates in the Drosophila embryo

The Drosophila tracheal system arises from clusters of ectodermal cells that invaginate and migrate to originate a network of epithelial tubes. Genetic analyses have identified several genes that are specifically expressed in the tracheal cells and are required for tracheal development. Among them,...

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Veröffentlicht in:Mechanisms of development 2000-03, Vol.91 (1), p.271-278
Hauptverfasser: Boube, Muriel, Llimargas, Marta, Casanova, Jordi
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Casanova, Jordi
description The Drosophila tracheal system arises from clusters of ectodermal cells that invaginate and migrate to originate a network of epithelial tubes. Genetic analyses have identified several genes that are specifically expressed in the tracheal cells and are required for tracheal development. Among them, trachealess ( trh) is able to induce ectopic tracheal pits and therefore it has been suggested that it would act as an inducer of tracheal cell fates; however, this capacity appears to be spatially restricted. Here we analyze the expression of the tracheal specific genes in the early steps of tracheal development and their cross-interactions. We find that there is a set of primary genes including trh and ventral veinless ( vvl) whose expression does not depend on any other tracheal gene and a set of downstream genes whose expression requires different combinations of the primary genes. We also find that the combined expression of primary genes is sufficient to induce some downstream genes but not others. These results indicate that there is not a single master gene responsible for the appropriate expression of the tracheal genes and support a model where tracheal cell fates are induced by the co-operation of several factors rather than by the activity of a single tracheal inducer.
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subjects Animals
breathless
DNA-Binding Proteins - genetics
DNA-Binding Proteins - physiology
Down-Regulation
Drosophila
Drosophila - embryology
Drosophila - genetics
Drosophila Proteins
Gene Expression Regulation, Developmental
Homeodomain Proteins - genetics
Homeodomain Proteins - physiology
Insect Proteins - genetics
Life Sciences
Membrane Proteins - genetics
Nuclear Proteins - genetics
POU Domain Factors
Protein-Tyrosine Kinases
Receptors, Fibroblast Growth Factor - genetics
Repressor Proteins - genetics
Trachea - embryology
Tracheal induction
trachealess
Transcription Factors - genetics
Transcription Factors - physiology
ventral veinless
title Cross-regulatory interactions among tracheal genes support a co-operative model for the induction of tracheal fates in the Drosophila embryo
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