Specialized replication mechanisms maintain genome stability at human centromeres

The high incidence of whole-arm chromosome aneuploidy and translocations in tumors suggests instability of centromeres, unique loci built on repetitive sequences and essential for chromosome separation. The causes behind this fragility and the mechanisms preserving centromere integrity remain elusiv...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular cell 2024-03, Vol.84 (6), p.1003-1020.e10
Hauptverfasser:	Scelfo, Andrea, Angrisani, Annapaola, Grillo, Marco, Barnes, Bethany M., Muyas, Francesc, Sauer, Carolin M., Leung, Chin Wei Brian, Dumont, Marie, Grison, Marine, Mazaud, David, Garnier, Mickaël, Guintini, Laetitia, Nelson, Louisa, Esashi, Fumiko, Cortés-Ciriano, Isidro, Taylor, Stephen S., Déjardin, Jérôme, Wilhelm, Therese, Fachinetti, Daniele
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer centromere Centromere - genetics DNA damage DNA replication genome instability Genomic Instability Humans Life Sciences mitosis Mitosis - genetics proteomics recombination Repetitive Sequences, Nucleic Acid replication stress
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!