Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: Study and human post-mortem examination
The involvement of psychotropic drugs in sudden deaths has been highlighted. The objective of this work was to establish a link between selenium levels in heart tissue, psychotropic treatment and sudden death. Selenium levels were measured by electrothermal atomic absorption spectroscopy post-mortem...
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| Veröffentlicht in: | Journal of trace elements in medicine and biology 2012-06, Vol.26 (2-3), p.170-173 |
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| container_title | Journal of trace elements in medicine and biology |
| container_volume | 26 |
| creator | Hamdan, Lamia Bost, Muriel Chazot, Guy Bui-Xuan, Bernard Vaillant, Fanny Dehina, Leila Descotes, Jacques Tabib, Alain Mamou, Zahida Timour, Quadiri |
| description | The involvement of psychotropic drugs in sudden deaths has been highlighted. The objective of this work was to establish a link between selenium levels in heart tissue, psychotropic treatment and sudden death. Selenium levels were measured by electrothermal atomic absorption spectroscopy post-mortem in heart, brain and liver. Histological examination evidenced dilated cardiomyopathy in 45% of cases, left ventricular hypertrophy in 36%, and ischemic coronaropathy in 18%. A significant reduction of myocardial selenium levels compared to controls was seen in patients treated with neuroleptic drugs or meprobamate. No changes in brain or liver selenium levels were seen. These results suggest that selenium deficiency can facilitate sudden death in patients on psychotropic drugs. The reduced activity of glutathione peroxidase due to selenium deficiency can result in augmented oxidative stress in myocardial cells and myocardiopathy leading to sudden death. |
| doi_str_mv | 10.1016/j.jtemb.2012.04.025 |
| format | Article |
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The objective of this work was to establish a link between selenium levels in heart tissue, psychotropic treatment and sudden death. Selenium levels were measured by electrothermal atomic absorption spectroscopy post-mortem in heart, brain and liver. Histological examination evidenced dilated cardiomyopathy in 45% of cases, left ventricular hypertrophy in 36%, and ischemic coronaropathy in 18%. A significant reduction of myocardial selenium levels compared to controls was seen in patients treated with neuroleptic drugs or meprobamate. No changes in brain or liver selenium levels were seen. These results suggest that selenium deficiency can facilitate sudden death in patients on psychotropic drugs. The reduced activity of glutathione peroxidase due to selenium deficiency can result in augmented oxidative stress in myocardial cells and myocardiopathy leading to sudden death.</description><identifier>ISSN: 0946-672X</identifier><identifier>EISSN: 1878-3252</identifier><identifier>DOI: 10.1016/j.jtemb.2012.04.025</identifier><identifier>PMID: 22664334</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Antipsychotic Agents - adverse effects ; Autopsy ; Death, Sudden - etiology ; Female ; Heart ; Humans ; Life Sciences ; Male ; Middle Aged ; Psychotropic drugs ; Selenium ; Selenium - deficiency ; Sudden death</subject><ispartof>Journal of trace elements in medicine and biology, 2012-06, Vol.26 (2-3), p.170-173</ispartof><rights>2012 Elsevier GmbH</rights><rights>Copyright © 2012 Elsevier GmbH. 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The objective of this work was to establish a link between selenium levels in heart tissue, psychotropic treatment and sudden death. Selenium levels were measured by electrothermal atomic absorption spectroscopy post-mortem in heart, brain and liver. Histological examination evidenced dilated cardiomyopathy in 45% of cases, left ventricular hypertrophy in 36%, and ischemic coronaropathy in 18%. A significant reduction of myocardial selenium levels compared to controls was seen in patients treated with neuroleptic drugs or meprobamate. No changes in brain or liver selenium levels were seen. These results suggest that selenium deficiency can facilitate sudden death in patients on psychotropic drugs. The reduced activity of glutathione peroxidase due to selenium deficiency can result in augmented oxidative stress in myocardial cells and myocardiopathy leading to sudden death.</description><subject>Adult</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Autopsy</subject><subject>Death, Sudden - etiology</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychotropic drugs</subject><subject>Selenium</subject><subject>Selenium - deficiency</subject><subject>Sudden death</subject><issn>0946-672X</issn><issn>1878-3252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1rFTEUxYMo9rX6FwiSpS5mzNd8CS5KsbbwwIUK7kJecqcvj0nyTDIPu_YfN9OpXbq6cPmdey7nIPSGkpoS2n441IcMblczQllNRE1Y8wxtaN_1FWcNe442ZBBt1Xbs5xk6T-lACO2anr1EZ4y1reBcbNCfW38K0wkc-IzDiD3MMUxwzFZjE-e7hK3HCSbwdnbYwGi1Ba_vsfIGp9kY8GWr8n4RaxWNVRqHaO-s_4i_5dms5H52yuNjSLlyIZa3MfxWznqVbfCv0ItRTQleP84L9OP68_erm2r79cvt1eW20nzguRJMa6EHaqDrB0J2gg2UMDqanTKDMprxUXGgXcmGQCvACEFN0wtN6dgOnPEL9H69u1eTPEbrVLyXQVl5c7mVy46IrqMNZSda2Hcre4zh1wwpS2eThmlSHsKc5OIsxFDMCspXVMeQUoTx6TYlcmlKHuRDU3JpqpjI0lRRvX00mHcOzJPmXzUF-LQCUCI5WYgyPUQPxkbQWZpg_2vwF5apptE</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Hamdan, Lamia</creator><creator>Bost, Muriel</creator><creator>Chazot, Guy</creator><creator>Bui-Xuan, Bernard</creator><creator>Vaillant, Fanny</creator><creator>Dehina, Leila</creator><creator>Descotes, Jacques</creator><creator>Tabib, Alain</creator><creator>Mamou, Zahida</creator><creator>Timour, Quadiri</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>201206</creationdate><title>Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: Study and human post-mortem examination</title><author>Hamdan, Lamia ; Bost, Muriel ; Chazot, Guy ; Bui-Xuan, Bernard ; Vaillant, Fanny ; Dehina, Leila ; Descotes, Jacques ; Tabib, Alain ; Mamou, Zahida ; Timour, Quadiri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-42cc4c91de78900b4291021fdbad9adc23fa3e170160e64ed441d584c11f69323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Autopsy</topic><topic>Death, Sudden - etiology</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychotropic drugs</topic><topic>Selenium</topic><topic>Selenium - deficiency</topic><topic>Sudden death</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamdan, Lamia</creatorcontrib><creatorcontrib>Bost, Muriel</creatorcontrib><creatorcontrib>Chazot, Guy</creatorcontrib><creatorcontrib>Bui-Xuan, Bernard</creatorcontrib><creatorcontrib>Vaillant, Fanny</creatorcontrib><creatorcontrib>Dehina, Leila</creatorcontrib><creatorcontrib>Descotes, Jacques</creatorcontrib><creatorcontrib>Tabib, Alain</creatorcontrib><creatorcontrib>Mamou, Zahida</creatorcontrib><creatorcontrib>Timour, Quadiri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of trace elements in medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamdan, Lamia</au><au>Bost, Muriel</au><au>Chazot, Guy</au><au>Bui-Xuan, Bernard</au><au>Vaillant, Fanny</au><au>Dehina, Leila</au><au>Descotes, Jacques</au><au>Tabib, Alain</au><au>Mamou, Zahida</au><au>Timour, Quadiri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: Study and human post-mortem examination</atitle><jtitle>Journal of trace elements in medicine and biology</jtitle><addtitle>J Trace Elem Med Biol</addtitle><date>2012-06</date><risdate>2012</risdate><volume>26</volume><issue>2-3</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>0946-672X</issn><eissn>1878-3252</eissn><abstract>The involvement of psychotropic drugs in sudden deaths has been highlighted. 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| ispartof | Journal of trace elements in medicine and biology, 2012-06, Vol.26 (2-3), p.170-173 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Antipsychotic Agents - adverse effects Autopsy Death, Sudden - etiology Female Heart Humans Life Sciences Male Middle Aged Psychotropic drugs Selenium Selenium - deficiency Sudden death |
| title | Involvement of neuroleptic drugs in selenium deficiency and sudden death of cardiac origin: Study and human post-mortem examination |
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